Publications by authors named "Ok Jin Jang"
Aims: This study aimed to assess treatment patterns and the effectiveness of long-acting injectable antipsychotics (LAIs) in patients with bipolar disorder (BD) across various Asian countries. The study focused on comparing the choices of LAIs, other psychotropic medications, and their psychotropic drug load to explore real-world usage and evaluate the potential benefits of LAIs in BD treatment across different countries.
Methods: A retrospective cohort study was conducted with BD patients diagnosed according to ICD-10-CM codes F31.
Background: As clinical practices with lithium salts for patients diagnosed with bipolar disorder (BD) are poorly documented in Asia, we studied the prevalence and clinical correlates of lithium use there to support international comparisons.
Methods: We conducted a cross-sectional study of use and dosing of lithium salts for BD patients across 13 Asian sites and evaluated bivariate relationships of lithium treatment with clinical correlates followed by multivariate logistic regression modeling.
Results: In a total of 2139 BD participants (52.
Article Synopsis
- This study analyzes the prescription patterns of mood stabilizers, primarily used for bipolar disorder, across 10 Asian countries and highlights their use in treating other psychiatric conditions.
- It found that more than half of the patients had schizophrenia or similar disorders, and symptoms like irritability and aggression were common targets for treatment.
- The results suggest that while mood stabilizers are frequently used off-label for various psychiatric diagnoses, the effectiveness and justification of this practice need further research.
Background: Pharmacoepidemiological studies of clozapine use to treat bipolar disorder (BD), especially in Asia, are rare, although they can provide insights into associated clinical characteristics and support international comparisons of indications and drug dosing.
Methods: We examined the prevalence and clinical correlates of clozapine treatment for BD in 13 Asian countries and regions (China, Hong Kong SAR, India, Indonesia, Japan, Korea, Malaysia, Myanmar, Pakistan, Singapore, Sri Lanka, Taiwan, and Thailand) within an Asian Prescription Patterns Research Consortium. We compared BD patients treated with clozapine or not in initial bivariate comparisons followed by multivariable logistic regression modeling.
Article Synopsis
- Clozapine combined with electroconvulsive therapy (ECT) is an effective treatment for patients with schizophrenia who do not respond to standard therapies, particularly in Asian populations.
- A study utilized machine learning techniques, specifically random forest and LASSO models, to create a prediction model identifying key variables that influence the success of this treatment combination, with significant results from a sample of 3,744 patients.
- Findings highlighted important factors such as inpatient status, BMI, and duration of illness, enabling a more tailored approach in treating schizophrenia through personalized medicine.
Article Synopsis
- * Conducted across 13 Asian countries, the research found that out of 1,647 participants, 13.1% were on high doses, with factors like younger age, male sex, and prior electroconvulsive treatment linked to this higher dosing.
- * The findings indicate significant variations in MS usage among different countries and highlight specific patient characteristics that could help in the individualized treatment of BD.
Prescription Patterns for Bipolar Disorder in Asian Countries: Findings from Research on Asian Prescription Pattern-Bipolar Disorder.
Clin Psychopharmacol Neurosci
February 2022
Article Synopsis
- - The REAP BD study investigated psychotropic medication prescription patterns for bipolar disorder across 12 Asian countries, highlighting the prevalence of polypharmacy and varied treatment approaches.
- - Data collected from 2003 patients showed that a majority were on multiple medications: 80.8% took mood stabilizers, 82.14% took antipsychotics, and the study found that 70% of patients were involved in polypharmacy practices.
- - Results indicated a significant increase in antipsychotic use, with over 80% of patients receiving them, suggesting an emerging trend in their use for treating bipolar disorder.
Objective: We investigated which factors in psychological changes positively or negatively affect the quality of life to suggest desirable directions in the period of the COVID-19 pandemic.
Methods: Online survey was conducted with 1,011 adults more than 19 years old in Busan, South Korea. Quality of life was measured using the World Health Organization Quality of Life-BREF.
Factors Influencing Readiness to Change Among Hazardous Drinkers in South Korea.
Psychiatry Clin Psychopharmacol
March 2021
the precontemplation group (those who had never considered that they had a problem) and the more than contemplation group (those who were at least open to the idea they might have a problem). Measured variables were personal characteristics, lifetime alcohol use history, and responses to the Drinker Inventory of Consequences, Alcohol Use Disorder Identification Test, Alcohol Dependence Scale, Motivational Structure Questionnaire for Alcoholics, and the Alcohol Outcome Expectancies Scale. Behavioral, psychiatric, and psychological factors were evaluated according to the responses to the Rosenberg Self-Esteem Scale, Zung Self-Rating Depression Scale, Barratt Impulsiveness Scale, State-Trait Anxiety Inventory, and State-Trait Anger Expression Inventory.
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- Language disorganization, a key symptom of schizophrenia, reflects abnormalities in formal thought processes and has not been extensively studied in terms of its network structure in patients.
- A study assessed 167 inpatients using the Clinical Language Disorder Rating Scale (CLANG), highlighting that top issues like disclosure failure, syntactic constraints, and prosody issues are central to language disorganization in schizophrenia.
- The study suggests that issues with top-down processing of language may be linked to neurobiological factors in schizophrenia, and future research should account for other influencing factors like illness duration.
Article Synopsis
- The study analyzed prescription patterns for bipolar disorder (BD) using Korean data, focusing on clinical features and medication use.
- Results showed that over 85% of patients experienced polypharmacy, with 51.1% in simple and 34.2% in complex polypharmacy, indicating more medication complexity among younger patients with more severe symptoms.
- The findings suggest a need for careful monitoring of weight and medication practices in patients with bipolar disorder who are on multiple drugs, as they tend to be more overweight and use fewer antidepressants but more anxiolytics.