Publications by authors named "Ojvind Lidegaard"
Lifetime Induced Abortions and Live Births: A 40-Year Historical Cohort Study.
J Obstet Gynaecol Can
September 2024
Objectives: Little is known about whether induced abortions are associated with the final lifetime number of live births (life births). The objective of this study was to examine the association between the number of life births with the number of abortions a female has had in her lifetime.
Methods: In a national cohort design, we followed all Danish females from ages 15 to 44 years through the period 1977-2017 for induced abortions and live births.
Objective: The authors compared the associated risk of incident depression between first-time users of low-, medium-, and high-dose levonorgestrel-releasing intrauterine systems (LNG-IUSs).
Methods: This national cohort study was based on Danish register data on first-time users of LNG-IUSs, 15-44 years of age, between 2000 and 2022. Cox regression and a G-formula estimator were used to report 1-year average absolute risks, risk differences, and risk ratios of incident depression, defined as initiation of an antidepressant or receipt of a depression diagnosis, standardized for calendar year, age, education level, parental history of mental disorders, endometriosis, menorrhagia, polycystic ovary syndrome, dysmenorrhea, leiomyoma, and postpartum initiation.
Background: The proportion of abortions provided by medication in the United States and worldwide has increased greatly since the U.S. Food and Drug Administration approved mifepristone in 2000.
View Article and Find Full Text PDFObjective: Gender-affirming care could be associated with higher employment rate. We assessed employment rates in transgender persons compared to controls and demographic, health, and treatment-related factors associated with employment in transgender persons.
Methods: National register-based cohort study in Danish persons with diagnosis code of gender dysphoria during year 2000-2021.
Background: In utero exposure to maternal cancer and cancer treatment might influence the child's cognitive development. This study investigated if exposure to maternal cancer during fetal life impacted school performance and educational achievement as adults.
Methods: This nationwide retrospective cohort study identified all live-born children in Denmark between January 1978 and December 2013.
Importance: Gender affirming treatment aims to improve mental health.
Objective: To investigate longitudinal mental health outcomes in Danish transgender persons.
Design: National register-based cohort study in Danish transgender persons with diagnosis code of "gender identity disorder" during the period 2000-2021.
Background Pregnancy loss has been associated with myocardial infarction, stroke, and all-cause mortality in women through unknown mechanisms. The aim of this study was to examine these associations in women and their male partners. Methods and Results In this register-based cohort study, all people born between 1957 and 1997, residing in Denmark between 1977 and 2017, and with a registered partner of the opposite sex were eligible for inclusion.
View Article and Find Full Text PDFImportance: Hormonal sensitivity may contribute to the risk of depression in some women, as observed during the premenstrual, postpartum, and perimenopausal phases, and when initiating hormonal contraception (HC). However, little evidence exists to support that such depressive episodes are linked across the reproductive life span.
Objective: To determine whether prior depression associated with HC initiation is coupled with a higher risk of postpartum depression (PPD) than prior depression not associated with HC initiation.
Background: Venous thromboembolism is a prominent cause of maternal death.
Objective: As inflammation is a well-known risk factor for venous thromboembolism and several studies have found a higher grade of inflammation in pregnancies bearing a male compared with female fetuses, we investigated the risk of pregnancy-related venous thromboembolism associated with sex of the fetus.
Methods: This cohort study linked data from national registries and compared event rates and hazard ratios of venous thrombosis for pregnancies bearing a male fetus with those bearing a female fetus during pregnancy and in the first 3 months postpartum.
Objective: To study whether endometriosis is associated with pregnancy loss and recurrent pregnancy loss (RPL).
Design: Nationwide historical cohort study with a nested case-control analysis.
Setting: National health registers.
Background: Cardiovascular risk could be increased in transgender persons, but the mechanism is undetermined.
Aim: The aim of this study was to assess the risk of cardiovascular outcomes in Danish transgender persons compared to controls.
Methods: The study design was a historical register-based cohort study in Danish transgenders and age-matched controls.
Purpose: In utero exposure to maternal cancer and cancer treatment might influence the child's short- and long-term health and development. The objective of the study was to investigate short- and long-term somatic and psychiatric outcomes in children exposed to maternal cancer in utero.
Methods: This nationwide cohort study identified all liveborn children in Denmark between January 1978 and December 2018.
Asthma Is Associated With Pregnancy Loss and Recurrent Pregnancy Loss: A Nationwide Cohort Study.
J Allergy Clin Immunol Pract
September 2022
Background: Women with asthma appear to have an increased risk of pregnancy loss (PL). The impact of asthma on recurrent pregnancy loss (RPL), defined as 3 consecutive losses, is, however, unknown.
Objective: The aim of this study was to investigate whether having asthma before or during the fertile age is associated with PL and RPL.
Background: Gender affirming hormonal treatment (GAHT) is a cornerstone in transgender care. National data are sparse regarding use of hormonal treatment by transgender persons.
Aim: To assess use of GAHT in transgender persons.
Background: The loss of one or more pregnancies before viability (i.e. pregnancy loss or miscarriage), has been linked to an increased risk of diseases later in life such as myocardial infarction and stroke.
View Article and Find Full Text PDFBackground And Purpose: Sex differences in multiple sclerosis (MS) prevalence and disease course are thought to be driven by hormones. Exogenous exposure to estrogens may affect MS disease course. Thus, our aim was to investigate the association between hormone therapy (HT) and disease activity and disability accrual among women with MS.
View Article and Find Full Text PDFReproductive changes among women in their 40s: A cross-sectional study.
Acta Obstet Gynecol Scand
February 2022
Introduction: The aim was to describe and compare changes in the reproductive pattern of women in their 40s observed over a decade in Scandinavia.
Material And Methods: Cross-sectional study using the total population of women aged 40-49 years between 2008-2018 in Denmark, Norway and Sweden (on average n = 1.5 million).
Objectives: To investigate the obstetrical management of cancer in pregnancy and to determine adverse pregnancy and neonatal outcomes.
Design: A nationwide cohort study.
Setting And Population: We included all pregnancies (n = 4 071 848) in Denmark from 1 January 1973 to 31 December 2018.
A severe decline in child births has occurred over the past half century, which will lead to considerable population declines, particularly in industrialized regions. A crucial question is whether this decline can be explained by economic and behavioural factors alone, as suggested by demographic reports, or to what degree biological factors are also involved. Here, we discuss data suggesting that human reproductive health is deteriorating in industrialized regions.
View Article and Find Full Text PDFArticle Synopsis
- A cohort study in Denmark analyzed 479,178 live-born children to assess whether epidural analgesia during labor increases autism risk.
- Approximately 19.4% of the children were exposed to epidurals, and 1.3% were diagnosed with autism by the end of follow-up.
- The analysis adjusted for various maternal and familial factors to determine the association between labor epidural use and autism diagnoses in offspring.
Introduction: The impact of early pregnancy complications on completed family size is unknown. Here, we hypothesize that early pregnancy complications and adverse outcomes may influence family size.
Material And Methods: In this nationwide, registry-based study we included all 458 475 women born 1957-1972 who lived in Denmark from age 20-45 years with at least one registered pregnancy.
Background: Gender dysphoria could be associated with low socioeconomic status (SES). SES could be modified by age, ethnic background, and medical morbidity.
Aim: To determine SES in a national study population including transgender persons in Denmark.
Gender incongruence in Denmark, a quantitative assessment.
Acta Obstet Gynecol Scand
October 2021
Introduction: The number of persons with gender incongruence referred to health care is increasing, but national data on the incidence of gender incongruence are lacking. The aim of this study was to quantify the development in number of individuals with gender incongruence over time and to estimate the national incidence in Denmark.
Material And Methods: Historical descriptive cohort study.