Publications by authors named "Ojembarrena E"

Background: Screening by means of biennial fecal occult blood test has provided a reduction in overall colorectal cancer mortality. Notwithstanding, we should not underestimate the harms that it can produce.

Aim: The aim of this article is to identify the independent risk factors of complications after a screening colonoscopy.

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Unlabelled: Colorectal cancer (CRC) is a major public health problem due to its incidence and mortality. In May 2008, the Basque Country approved the implementation of a population-based colorectal cancer screening program, using the immunochemical fecal occult blood test (FOBT), in persons aged 50-69 years. Patients with a positive result were invited to undergo colonoscopy with sedation.

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Objective: To describe the procedures of the colorectal cancer screening program in the Basque Country (Spain), and the main results of the first rounds in 2009-2011.

Method: We carried out a retrospective study of invitations to attend screening between 2009 and 2011. Participation rates and the number of positive results of the fecal occult blood test (FOBT) were analyzed by sex and age group.

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Background: Endoscopic sclerotherapy (EST) with ethanolamine oleate (EO) was proposed as a treatment for achalasia, based on the well-known necrotizing effect against the esophageal muscle layers. The aim of this study is to evaluate long-term efficacy of EST.

Methods: Four consecutive series of patients with achalasia were treated according to different schedules over a period of 20 years, by using EO or polidocanol (PD).

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Hereditary non-polyposis colorectal cancer (HNPCC) or Lynch syndrome underlies between 2 and 5% of all colorectal cancer. It is inherited as an autosomal dominant condition due to mutations in the mismatch repair genes. Fifty-four non-related index cases, 21 of them fulfilling Amsterdam criteria I or II, were studied.

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Hereditary nonpolyposis colorectal cancer (HNPCC), which represents the most common form of inherited colorectal cancer, results from germline alterations of the mismatch repair genes MSH2, MLH1 and MSH6. Rearrangements of MSH2 and MLH1 are involved in at least 10% and 4.3%, respectively, of the HNPCC families fulfilling the Amsterdam (AMS) criteria.

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Background And Study Aims: The present study aimed to test the hypothesis that endoscopic sclerotherapy may effectively reduce the occurrence of spasm at the level of the gastric cardia, offering an effective treatment for achalasia.

Patients And Methods: We prospectively treated 33 achalasia patients by repeated injection of ethanolamine oleate at the cardiac level. Twenty patients (series I) were reassessed after six to nine months, with a mean follow-up of 31.

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Short term sclerotherapy (by injection(s) around the bleeding point) is used for immediate control of massive haemorrhage from oesophagogastric varices. The usefulness of longterm sclerotherapy once short term sclerotherapy has been successfully carried out was assessed. Two treatment groups were studied: 50 patients were treated by 'combined' (short term followed by longterm) sclerotherapy; 56 patients were treated by short term sclerotherapy only.

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Idiopathic acute esophageal necrosis (AEN) has been considered a rare event, usually having an ischemic origin. Primarily cases from autopsy studies have been reported. This report deals with 10 such cases which were diagnosed among some 80,000 esophago-gastroscopies performed during a 16-year period.

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The injection of a mixture of ethanolamine oleate and thrombin as an effective treatment for bleeding duodenal ulcer was evaluated in 38 patients entered in a randomised prospective controlled trial. After a one week observation period, 1/19 (5.3%) treated patients and 11/19 (57.

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Sengstaken-Blakemore tamponade is used for the initial control of bleeding esophageal varices (BEV), although it is known to be potentially dangerous. Sclerotherapy has been shown to be effective in the treatment of BEV. This trial has been designed to evaluate comparatively the effectiveness of both procedures in the initial control of the hemorrhage.

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Having reviewed 47 cases of vascular malformations of the stomach and duodenum, we propose an endoscopic classification for these lesions: Pattern I (flat or slightly protruded, bright red lesions with frond-like margin) is the most usual form of presentation. The "telangiectatic form" (pattern II) is an endoscopic variation, with the same clinical and, possibly, pathogenic significance. Submucosal nodular forms (pattern III) are the most difficult to diagnose and treat.

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To investigate the significance of gastric xanthelasma, a retrospective review of 109 cases with an endoscopic diagnosis of this lesion was undertaken. A predominance in older patients was noted, with a similar distribution in antrum and fornix. In 15 cases (16.

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Linoleic and arachidonic acids were studied in 18 healthy full term newborn infants during the neonatal period. A percentual decrease of arachidonic acid relative to blood umbilical cord values was observed at 24 hours of life. No changes in linoleic acid were observed.

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Percentage of fatty acids in phospholipids of red cell membranes from cord blood of 13 full-term and 11 premature infants is studied. Percentage of 22:5n6, final metabolite of n6 series, was significantly diminished in premature infants, whereas the percentage of arachidonic acid was significantly increased in the same group. The possibility that an enzymatic abnormality be present in desaturation from 22:4n6 to 22:5n6 is speculated, as well as of its physiologic implications.

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A case of maple syrup urine disease is described presenting during diet therapy a clinical picture with predominant cutaneous symptoms attributed to a dietary deficiency. It is believed that probable cause was the coexistence of low serum levels of isoleucine with still elevated levels of leucine. Given the metabolic interrelationship existing between different branch-chained amino acids, an independent dietary correction of each amino acid is recommended.

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A total of 40 blood samples (8 from umbilical cord, 12 from infants aged 0-2 years, and 20 from older children) have been analyzed. Fatty acid composition of different plasma lipidic fractions were determined. The differences showed between these age groups are described.

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Changes in essential fatty acids of twenty two patients during parenteral nutrition are studied. Two populations (neonatal and others) were differencied. In the neonatal group a percentual decrease in arachidonic acid was showed.

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