Publications by authors named "Oishani Banerjee"
Article Synopsis
- Aortic aneurysms and dissections (AAD) lead to over 10,000 deaths annually in the U.S., and currently, there are no effective medications to prevent them.
- Researchers focused on ascending aortic aneurysms and dissections (AAAD) and explored the role of the MerTK receptor in endothelial cells as it relates to AAAD progression.
- Utilizing advanced techniques like single-cell RNA sequencing and a specific mouse model lacking MerTK in endothelial cells, the study found that MerTK deficiency significantly increases the risk of AAAD by causing endothelial dysfunction and changes in smooth muscle cell behavior.
MER proto-oncogene tyrosine kinase (MerTK) is a key receptor for efferocytosis, a process for the clearance of apoptotic cells. MerTK is mainly expressed in macrophages and immature dendritic cells. There are very limited reports focused on MerTK biology in aortic endothelial cells (ECs).
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