Publications by authors named "Oikonomou T"

Background: Preventing disease progression and viral suppression are the main goals of antiviral therapy in chronic hepatitis B (CHB). Liver stiffness measurement (LSM) by transient elastography is a reliable non-invasive method to assess liver fibrosis in patients with CHB. Our aim was to explore factors that may affect changes in LSMs during long term tenofovir (TDF) monotherapy in a well characterized cohort of patients with compensated CHB.

View Article and Find Full Text PDF

Background: The use of nucleos(t)ide analogs (NAs) with a high genetic barrier to resistance, namely entecavir and tenofovir, has improved the efficacy of antiviral prophylaxis against hepatitis B virus (HBV) recurrence after liver transplantation (LT). However, the optimal duration and dosage of hepatitis B immunoglobulin (HBIG) administration, particularly in patients transplanted for HBV and hepatitis D virus (HDV) coinfection, remains controversial.

Methods: We evaluated 28 patients transplanted for HBV/HDV cirrhosis.

View Article and Find Full Text PDF
Article Synopsis
  • The study examined the significance of platelet (PLT)-based biomarkers in predicting outcomes for 525 patients with stable decompensated cirrhosis, focusing on variables like mean PLT volume and various PLT-based scores.
  • Results indicated that the aspartate aminotransferase-to-PLT ratio index (APRI) strongly correlated with survival outcomes, more so than traditional scoring systems like MELD and CTP.
  • The findings suggest that APRI could serve as an effective noninvasive predictor for patient prognosis in decompensated cirrhosis, offering a new approach to assess liver disease severity.*
View Article and Find Full Text PDF
Article Synopsis
  • TAF was found to be just as effective as TDF in suppressing hepatitis B virus (HBV) but had less impact on kidney health.
  • This study compared post-liver transplant patients who switched from TDF to TAF due to low kidney function against those who remained on TDF, revealing no significant differences in renal function over a year.
  • While no adverse effects from TAF were reported, and it showed a slight numerical improvement in kidney function, the overall conclusion was that switching to TAF did not significantly help kidney health for patients with chronic kidney disease (CKD) after one year.
View Article and Find Full Text PDF

Background: Galectin-3 (gal-3) has been proposed as a marker of established renal impairment, with predictive value in stable decompensated cirrhosis.

Methods: 150 stable decompensated patients were assessed in 2 transplant centers. Patients' renal function was assessed using Chromium-EDTA ("true" glomerular filtration rate).

View Article and Find Full Text PDF

After a brief introduction to the theory underlying block-entropy and its relation to the dynamics of complex systems as well as certain information theory aspects, we study musical texts coming from two distinct musical traditions, Japanese and Western European, encoded via symbolic dynamics. We quantify their information content, also known as the degree of "non-randomness" which essentially defines the complexity of the text. We analyze the departure of "total randomness" to the constraints underlying the dynamics of the symbol generating process.

View Article and Find Full Text PDF

Introduction: The period of basic military training (BMT) is a sudden change in the individual habits of the trainees and is characterized by significant improvements in body composition such as the percentage of body fat (%BF) and lean body mass (BM). Research has shown that physical activity during the period of BMT lasting 7-10 weeks has positive effects on the physical condition and BM of cadets. The purpose of this study was to examine the effects of training combining cardiovascular conditioning, circuit strength training, swimming, team sports, and obstacle course on physical fitness and body composition during a 10-week BMT period over 4 years in the Hellenic Naval Academy (HNA).

View Article and Find Full Text PDF

Background: Prognostic indicators in patients with decompensated cirrhosis are vital for the estimation of death risk. The ratio of C-reactive protein to albumin (CAR) has been verified as a prognostic marker in patients with hepatocellular carcinoma and decompensated cirrhosis related to hepatitis B virus. Neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), and gamma globulins have been separately studied in cirrhosis.

View Article and Find Full Text PDF

Background: In the setting of the oral-gut-liver axis, microbiome dysbiosis has been associated with decompensated cirrhosis progression. However, little is known on salivary microbiome profiles in stable decompensated patients.

Methods: We studied patients with stable decompensated cirrhosis (n =28) and matched healthy controls (n =26).

View Article and Find Full Text PDF

We reply to the preceding Comment by Jizba and Korbel [Jizba and Korbel, Phys. Rev. E 100, 026101 (2019)10.

View Article and Find Full Text PDF

Background: Newly introduced galectin-3 (gal-3) has been associated to impaired renal function. Gal-3 may become prognostic biomarker in hepatic diseases.

Aim: To investigate the association of gal-3 with prognosis and renal function in patients with stable decompensated cirrhosis.

View Article and Find Full Text PDF

Introduction And Aim: Studies carried out mainly in patients with hepatocellular carcinoma (HCC), have shown the prognostic significance of albumin-bilirubin (ALBI) grade. Recently, another predictive score incorporating platelet count into ALBI, PALBI grade, was introduced in patients with HCC.

Aim: We evaluated the ability of ALBI and PALBI grades in predicting the outcome (mortality / liver transplantation) of patients with stable decompensated cirrhosis with various etiology of liver diseases.

View Article and Find Full Text PDF

We show that the Rényi entropy implies artificial biases not warranted by the data and incorrect updating information due to the finite size of the data despite being additive. It is demonstrated that this is so because it does not conform to the system and subset independence axioms of Shore and Johnson [J. IEEE Trans.

View Article and Find Full Text PDF

Panagoulis, C, Chatzinikolaou, A, Avloniti, A, Leontsini, D, Deli, CK, Draganidis, D, Stampoulis, T, Oikonomou, T, Papanikolaou, K, Rafailakis, L, Kambas, A, Jamurtas, AZ, and Fatouros, IG. In-season integrative neuromuscular strength training improves performance of early-adolescent soccer athletes. J Strength Cond Res 34(2): 516-526, 2020-Although forms of integrative neuromuscular training (INT) are used extensively for injury prevention and treatment, no information exists about its effects on performance of adolescent athletes.

View Article and Find Full Text PDF

Cirrhosis is an increasing cause of morbidity and mortality. Recent studies are trying to clarify the role of microbiome in clinical exacerbation of patients with decompensated cirrhosis. Nowadays, it is accepted that patients with cirrhosis have altered salivary and enteric microbiome, characterized by the presence of dysbiosis.

View Article and Find Full Text PDF

It has been known for some time that the usual q-entropy S_{q}^{(n)} cannot be shown to converge to the continuous case. In Phys. Rev.

View Article and Find Full Text PDF

The existence and exact form of the continuum expression of the discrete nonlogarithmic q-entropy is an important open problem in generalized thermostatistics, since its possible lack implies that nonlogarithmic q-entropy is irrelevant for the continuous classical systems. In this work, we show how the discrete nonlogarithmic q-entropy in fact converges in the continuous limit and the negative of the q-entropy with continuous variables is demonstrated to lead to the (Csiszár type) q-relative entropy just as the relation between the continuous Boltzmann-Gibbs expression and the Kullback-Leibler relative entropy. As a result, we conclude that there is no obstacle for the applicability of the q-entropy to the continuous classical physical systems.

View Article and Find Full Text PDF

Autoimmune hepatitis (AIH) is a progressive, chronic liver disease characterized by unresolving hepatocellular inflammation of autoimmune origin. The clinical spectrum may vary from asymptomatic presentation, to non-specific symptoms such as fatigue, arthralgias, nausea and abdominal pain, to acute severe liver disease. AIH is characterized by the presence of interface hepatitis and portal plasma cell infiltration on histological examination, hypergammaglobulinemia, and positive autoantibodies.

View Article and Find Full Text PDF

Background: The clinical impact of relative adrenal insufficiency (AI) on patients with stable decompensated cirrhosis (DeCi) has not been yet elucidated.

Aim: Explore the association between AI and outcome [death or liver transplantation (LT)] in patients with DeCi.

Material And Methods: Patients with DeCi presenting no active complication have been included.

View Article and Find Full Text PDF

Background: Hepatopulmonary syndrome (HPS) is a relatively common complication in patients with decompensated cirrhosis. Our aim was to evaluate the prevalence of HPS, its clinical impact, and the possible association between HPS and characteristics of patients with decompensated cirrhosis.

Methods: Patients with stable decompensated cirrhosis admitted to our department and assessed for HPS were included.

View Article and Find Full Text PDF

Background: Studies in patients with decompensated cirrhosis showed a correlation between serum ferritin levels and patients' prognosis. Besides, red blood cell distribution width (RDW) and mean platelet volume (MPV) have been associated with the severity of hepatic function. The aim of this study was to evaluate the prognostic impact of serum ferritin and RDW/MPV in the outcome [survival, death, or liver transplantation (LT)] of patients with stable decompensated cirrhosis.

View Article and Find Full Text PDF