Publications by authors named "Ohya A"

Purpose: To reveal problems of magnetic resonance imaging (MRI) for diagnosing gastric-type mucin-positive (GMPLs) and gastric-type mucin-negative (GMNLs) cervical lesions.

Methods: We selected 172 patients suspected to have lobular endocervical glandular hyperplasia; their pelvic MR images were categorised into the training (n = 132) and validation (n = 40) groups. The images of the validation group were read twice by three pairs of six readers to reveal the accuracy, area under the curve (AUC), and intraclass correlation coefficient (ICC).

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Purpose: The purposes of the study are to assess the diagnostic performance of preoperative imaging for staging factors in gastric-type endocervical adenocarcinoma (GEA) and to compare the performance for GEA with that of usual-type endocervical adenocarcinoma (UEA) among patients preoperatively deemed locally early stage (DLES) (< T2b without distant metastasis).

Materials And Methods: For this multi-center retrospective study, 58 patients were enrolled. All had undergone MRI with or without CT and FDG PET-CT preoperatively and had been pathologically diagnosed with GEA at five institutions.

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  • The study focuses on placenta previa complicated by placenta accrete spectrum (PAS), emphasizing the need for preoperative diagnosis to ensure proper management of this serious condition.
  • Researchers analyzed MRI images from 145 patients to identify 11 features related to PAS, finding eight features significantly correlated with the condition, particularly placental/uterine bulge and myometrial thinning.
  • A decision tree model, based on five key MRI features, was developed and demonstrated high sensitivity (90%) and specificity (95.5%) for predicting PAS in patients diagnosed with placenta previa.
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Background: Primary ciliary dyskinesia (PCD) is a rare genetic disease caused by defects in various genes affecting ciliary function. It is currently unclear why DRC1 gene variants are a relatively frequent cause of disease in Japanese and Korean patients.

Methods: A 12-year-old Japanese girl with bronchiectasis was suspected of PCD and examined using whole-exome sequencing (WES).

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  • The study aimed to assess the performance of a specific mixture (n-butyl cyanoacrylate-Lipiodol-iopamidol) in embolizing medium-sized arteries using various scenarios, including the use of microcoils and flow control.
  • An experimental model of the common hepatic artery was tested under six different embolization scenarios, observing the migration of the mixture after injection.
  • Results showed that the mixture effectively embolized the arteries when combined with microcoils, especially with flow control, but without flow control, it led to partial migration of the mixture away from the target site.
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  • Placental site trophoblastic tumor (PSTT) is a rare type of tumor arising from the placenta, and this study documented MRI findings in four cases, highlighting a specific feature known as "pseudo-myometrial thinning."
  • The researchers analyzed MRIs and pathology results, measuring the thickness of myometrium (the muscular layer of the uterus) beneath the tumor compared to normal myometrium, finding that the MRI measurements showed significant thinning.
  • Results indicated that while tumors appeared to invade deeply into the myometrium on imaging, they were actually localized within the superficial layer, suggesting that MRI could misrepresent the extent of tissue invasion, potentially due to compression effects.
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  • The development of automatic pathological diagnostic systems using AI aims to enhance the efficiency of diagnosing diseases, although challenges like low interpretability and high data requirements persist.
  • A new general-purpose approach combining a hyperspectral camera with machine learning shows promise, achieving over 80% accuracy in identifying benign or malignant cells in challenging bile duct biopsy and bile cytology specimens.
  • This method could significantly aid in diagnosing bile duct cancer and has the potential for broader applications in general pathological diagnoses.
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Purpose: This study aims to evaluate and identify magnetic resonance (MR) findings of mural nodules to detect squamous cell carcinoma arising from ovarian mature cystic teratoma (SCC-MCT).

Methods: This retrospective study examined 135 patients (SCC-MCTs, n = 12; and benign MCTs, n = 123) with confirmed diagnoses across five different institutions between January 2010 and June 2022. Preoperative MR images for each patient were independently assessed by two experienced radiologists and analyzed following previously reported findings (PRFs): age, tumor size, presence of mural nodules, size of mural nodule, and the angle between mural nodule and cyst wall (acute or obtuse).

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A 63-year-old Japanese woman presented to the emergency room with a fever and altered mental status. She was diagnosed as acute cholangitis and coronavirus disease 2019 (COVID-19). On the second day, her consciousness level deteriorated.

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This study aimed to characterize calyculin A (CL-A)-induced and thimerosal-induced hyperactivation of cryopreserved bovine spermatozoa. Hyperactivation was effectively induced by treating with 10 nM CL-A for 60 min in the presence of cyclic AMP analogs, extracellular Ca, and albumin or with 12.5 µM thimerosal briefly in the absence of these capacitation-supporting factors.

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Background: Subarachnoid hemorrhage and thyroid storm are similar in their clinical symptomatology, and diagnosis of these conditions, when they occur simultaneously, is difficult. Here, we report a rare case of concurrent subarachnoid hemorrhage and thyroid storm we encountered at our hospital.

Case Presentation: The patient was a 52-year-old woman.

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  • Ovarian tumors come in various types that often appear similar on imaging, making them hard to differentiate, yet the number of common types is relatively fixed in clinical practice.
  • MRI is a valuable tool for distinguishing between these tumors, and five typical types of MRI findings can guide diagnoses.
  • Accurate diagnosis often relies on analyzing specific MRI characteristics, changes over time, and additional data from tumor markers, which is crucial for deciding the best treatment approach.
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  • The study evaluated the safety and effectiveness of preoperative arterial embolization for organized hematomas in the maxillary sinus, involving seven patients who underwent this procedure prior to endoscopic sinus surgery.
  • The results showed no complications from embolization, with a median surgical blood loss of 30 mL and surgery time of 112 minutes, indicating a significant reduction in blood loss compared to non-embolization cases.
  • The findings suggest that preoperative embolization is a safe and efficient approach to minimize serious bleeding during surgery for organized hematomas of the maxillary sinus.
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Lung ultrasound (LUS), a rapid, bedside, goal-oriented diagnostic test, can be quantitatively assessed, and the scores can be used to evaluate disease progression. However, little data exists on predicting prolonged mechanical ventilation (PMV) and successful extubation using serial LUS scores. We examined the relationship of PMV with successful extubation in patients with severe coronavirus disease (COVID-19) by using two types of serial LUS scores.

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Background: Research has suggested an association between emotion regulation strategies (ERSs) and abnormal eating behaviours/attitudes (AEB), and many studies have examined the association of one particular ERS with AEB. Additionally, different ERSs are reported to be strongly correlated with each other. Therefore, the associations between an individual ERS and AEB, reported previously, may be spurious.

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  • - Ovarian primary mucinous tumors (OPMTs) progress through a sequence from benign adenoma to borderline and malignant carcinoma, with unique glycan markers like α1,4-linked -acetylglucosamine (αGlcNAc) found on mucin 6 (MUC6).
  • - A study of 104 benign, 55 borderline, and 18 malignant tumor areas revealed that while MUC5AC was consistently expressed, the expression of αGlcNAc and MUC6 decreased significantly as tumors progressed.
  • - The findings indicate that the reduced expression of αGlcNAc relative to MUC6 may signal early tumor development and initiate the progression of OPMTs. *
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  • The study aimed to assess how MRI features and tumor markers can help differentiate between benign, borderline, and malignant grades of ovarian primary mucinous tumors (OPMTs).
  • It analyzed 95 cases using various MRI characteristics such as maximum diameter, honeycomb loculi, and specific tumor markers (CEA, CA 19-9, CA125) to find significant differences among the tumor grades.
  • The findings indicated that certain MRI patterns and tumor marker levels could effectively classify OPMTs, with specific combinations suggesting benign, borderline, or malignant diagnoses.
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Aim: To evaluate the usefulness of the 'cosmos pattern' (CP) on magnetic resonance (MR) images for differentiating between gastric-type mucin-positive lesions (GMPL) and gastric-type mucin-negative lesions (GMNL).

Methods: This study included 131 patients with clinical suspicion of lobular endocervical glandular hyperplasia (LEGH) who underwent pelvic MR imaging and a Pap smear and/or latex agglutination assay. Differences in MR findings, such as cyst and solid component patterns, cervical location and T1-weighted image (T1WI) signal intensity, were compared between GMPL and GMNL.

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  • The study aimed to analyze the MRI features and staging of neuroendocrine carcinoma (NEC) of the uterine cervix, while also examining the relationship between pathology and survival rates.
  • Findings indicated that most cases showed a slightly high signal intensity and restricted diffusion in MRI scans, with a high overall accuracy of 88% for staging when compared to pathology results.
  • The research revealed that fewer patients with advanced stages (III and IV) had favorable survival outcomes, with significant recurrence rates observed during the follow-up period.
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Introduction: Although lobular endocervical glandular hyperplasia is a benign disorder of the uterine cervix, its potential as a precursor of minimal deviation adenocarcinoma has been reported. However, the natural history of the disease and the frequency of malignant change are not fully understood. We evaluated the frequency of malignant change of clinical lobular endocervical glandular hyperplasia and explored useful parameters indicating malignant change.

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We, Team SAIL, held the workshop at WONCA APR Conference 2019 for presenting the concept of Social Vital Signs (SVS) to an international audience.

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•We report a case of MDA arising from clinical LEGH during 5 years of follow-up.•The first sign suggesting MDA was cellular atypia in endocervical cytology, and was followed by an increase in tumor size.•MDA lesion lacked in stromal reaction and MRI failed to detected MDA.

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Background: Obesity is an important factor affecting incidence and development of musculoskeletal degenerative changes. In addition, obese patients are considered less favorable surgical candidates for decompression surgery in degenerative lumbar spinal canal stenosis and lower limb arthroplasty. The purpose was to assess disease characteristics of lumbar spinal canal stenosis as well as lower limb osteoarthritis, and to investigate surgical times based on body mass index (BMI) in lumbar decompressive surgery and lower limb arthroplasties.

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  • Team SAIL has conducted sessions on social vital signs (SVS).
  • SVS is a valuable tool designed to assess patients' social determinants of health (SDH).
  • The purpose of using SVS is to gain insight into how social factors impact health outcomes for patients.
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Purpose: To compare the visualization of hemodynamic imaging findings of hypervascular hepatocellular carcinoma (HCC) on dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) using radial volumetric imaging breath-hold examination with k-space-weighted image contrast reconstruction (r-VIBE-KWIC) versus dynamic computed tomography during hepatic arteriography (dyn-CTHA).

Materials And Methods: We retrospectively reviewed the databases of preoperative DCE-MRI using r-VIBE-KWIC, dyn-CTHA, and postoperative pathology of resected specimens. Fourteen patients with 14 hypervascular HCCs underwent both DCE-MRI and dyn-CTHA.

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