Publications by authors named "Ohsang Kwon"

Background And Objectives: This retrospective review study aimed to determine whether functional mobility test (FMT) results are related to the incidence of proximal junctional kyphosis (PJK) after surgical correction of adult spinal deformity (ASD).

Methods: A total of 157 patients who underwent reconstructive spinal surgery for ASD between July 2019 and December 2021 were included in this study. Three types of FMTs were performed preoperatively: timed-up-and-go (TUG) test, five times sit-to-stand (STS) test, and alternate step (AS) test.

View Article and Find Full Text PDF

Purpose: Recent advancements in interventional radiology have made angioembolization an invaluable modality in trauma care. Angioembolization is typically performed by interventional radiologists. In this study, we aimed to investigate the safety and efficacy of emergency angioembolization performed by trauma surgeons.

View Article and Find Full Text PDF
Article Synopsis
  • Severe abdominal injuries often require quick surgical responses, and a study at Jeju Regional Trauma Center evaluated the effectiveness and outcomes of emergency department (ED) versus operating room (OR) laparotomies from 2020 to 2022.
  • Out of 105 trauma patients who had laparotomies, only 6 underwent ED laparotomies, which showed a high mortality rate of 66.7%, compared to 17.1% for OR laparotomies; however, those in the ED group received quicker treatment.
  • Despite the higher mortality, the significantly shorter time to surgery in the ED (28.5 minutes) versus the OR (104 minutes) highlights the urgent nature of these cases, particularly for patients with severe
View Article and Find Full Text PDF

Background And Objectives: Several studies have explored strategies to prevent proximal junctional kyphosis (PJK) which is the unresolved issue in adult spinal deformity (ASD) surgery. This study aimed to investigate the preventive effects of upper instrumented vertebrae (UIV) recombinant human bone morphogenetic protein-2 (rhBMP-2) with beta-tricalcium phosphate (β-TCP) carrier injection on PJK.

Methods: This study was conducted through a retrospective analysis of data collected both prospectively and retrospectively.

View Article and Find Full Text PDF
Article Synopsis
  • - The study examines the relationship between telogen effluvium (TE), COVID-19, and COVID-19 vaccinations in patients at dermatology clinics in South Korea.
  • - Results showed a significant increase in TE cases after the COVID-19 pandemic, while vaccination appeared to have no impact on TE occurrence.
  • - The findings suggest a correlation between the pandemic and TE, but the retrospective design limits the ability to determine causation.
View Article and Find Full Text PDF

Importance: Baricitinib has demonstrated efficacy for treating severe alopecia areata in adults. There is currently limited information about the need for continuous therapy after achieving scalp hair regrowth.

Objective: To report results from the randomized withdrawal period of the BRAVE-AA1 trial.

View Article and Find Full Text PDF
Article Synopsis
  • The study aimed to establish clear criteria for classifying the severity of alopecia areata (AA), as no universal guidelines existed prior to this research.! -
  • A consensus was reached among experts, resulting in a severity classification system that uses the severity of alopecia tool (SALT) and categorizes AA as mild, moderate, or severe based on specific thresholds.! -
  • The new criteria will assist clinicians in diagnosing AA more accurately, determining suitable treatments, and effectively monitoring the condition's progression.!
View Article and Find Full Text PDF

Alopecia areata (AA) is a clinically heterogeneous, immune-mediated, non-scarring hair loss disorder. This real-world chart review sought to characterize treatment patterns and healthcare resource use among patients with severe AA in South Korea. A web-based chart review of 40 dermatologists was conducted in which the medical charts of 151 adult patients diagnosed with severe AA between May 2019 and April 2021 were reviewed.

View Article and Find Full Text PDF

Corticotropin-releasing hormone (CRH) is a key mediator in stress-induced hair growth inhibition. Here, we investigated the impact of stress-induced senescence and evaluated the potential of (GL) extract in mitigating CRH-induced senescence in human hair follicle cells (hHFCs). We show that CRH treatment increased the senescence-associated beta-galactosidase (SA-β-GAL) activity and reactive oxygen species (ROS) formation in hHFCs and suppressed alkaline phosphatase (ALP) activity and anagen-inducing genes.

View Article and Find Full Text PDF
Article Synopsis
  • * 25 patients received the injection, while 75 controls underwent traditional surgery; results showed significantly lower PJK and PJF rates in the treatment group.
  • * CT scans indicated increased bone formation at the UIV after 6 months in the rhBMP-2 group, suggesting that this method supports new bone growth and improves surgical outcomes.
View Article and Find Full Text PDF
Article Synopsis
  • The study investigates the effectiveness of three types of demineralized bone matrix (DBM) - Exfuse, Bongener, and Bonfuse - in promoting bone fusion during posterior lumbar interbody fusion (PLIF) surgery for patients over 50 with degenerative lumbar disease.
  • A retrospective review of 236 patients showed fusion rates of approximately 88% for Exfuse, 94% for Bongener, and 88% for Bonfuse, with no significant differences among them.
  • All three DBMs led to notable improvements in pain and disability scores at 12 months post-surgery, indicating that while they are effective, none showed superiority over the others in fusion rates or clinical outcomes.
View Article and Find Full Text PDF

Chemotherapy-induced alopecia (CIA) is a common and debilitating condition in children, with limited research on its characteristics and treatment. Therefore, this study aims to describe the characteristics of pediatric patients with CIA and the treatment outcomes of topical minoxidil and L-cystine, medicinal yeast, and pantothenic acid complex-based dietary supplements (CYP). This retrospective cohort study analyzed data from patients who underwent high-dose conditioning chemotherapy followed by hematopoietic stem cell transplantation and were treated with either topical minoxidil or CYP for CIA between January 2011 and January 2022.

View Article and Find Full Text PDF

Primary cicatricial alopecia (PCA) is a rare, scarring, hair loss disorder. Due to its low incidence, little is known about endocrine and metabolic comorbidities in patients with PCA. Thus, we aimed to investigate the association between PCA and endocrine and metabolic disorders.

View Article and Find Full Text PDF

Several single-cell RNA studies of developing mouse skin have elucidated the molecular and cellular processes involved in skin development. However, they have primarily focused on either the fetal or early postnatal period, leaving a gap in our understanding of skin development. In this study, we conducted a comprehensive time-series analysis by combining single-cell RNA-sequencing datasets collected at different stages of development (embryonic days 13.

View Article and Find Full Text PDF

Objectives: The present analyses report integrated results from BRAVE-AA1 (NCT03570749) and BRAVE-AA2 (NCT03899259) on the clinical benefits of baricitinib treatment on the basis of the amount of scalp hair regrowth through 52 weeks of treatment.

Methods: This post hoc analysis was conducted with data from patients who were treated continuously for 52 weeks with baricitinib 4 mg or 2 mg. Clinical outcomes were assessed using the Severity of Alopecia Tool (SALT) and Clinician-Reported Outcome (ClinRO) for Eyebrow (EB) and Eyelash (EL) hair.

View Article and Find Full Text PDF

Unlabelled: Non-invasive brain-computer interfaces (BCIs) based on an event-related potential (ERP) component, P300, elicited via the oddball paradigm, have been extensively developed to enable device control and communication. While most P300-based BCIs employ visual stimuli in the oddball paradigm, auditory P300-based BCIs also need to be developed for users with unreliable gaze control or limited visual processing. Specifically, auditory BCIs without additional visual support or multi-channel sound sources can broaden the application areas of BCIs.

View Article and Find Full Text PDF

Introduction: Hair loss is a common phenomenon associated with various environmental and genetic factors. Mitochondrial dysfunction-induced oxidative stress has been recognized as a crucial determinant of hair follicle (HF) biology. Aldehyde dehydrogenase 2 (ALDH2) mitigates oxidative stress by detoxifying acetaldehyde.

View Article and Find Full Text PDF

: Lumbar decompression with fusion surgery is an effective treatment for spinal stenosis, but critical postoperative hematoma is a concern. Bone wax has been widely used to control bone bleeding but it has some drawbacks. This study aimed to evaluate the efficacy of Tableau wax, a bioabsorbable hemostatic material, in patients undergoing spinal fusion surgery through a pilot study design.

View Article and Find Full Text PDF

Purpose: This study aims to present ophthalmic manifestations of 2 infants with hereditary mucoepithelial dysplasia (HMD) related to SREBF1 mutation over a 5-year period.

Methods: Two female infants with an unremarkable perinatal history were evaluated for photophobia that had been manifest since 3 months after birth and diffuse scalp alopecia. Complete ocular examinations under anesthesia were performed, as well as genetic and systemic workup.

View Article and Find Full Text PDF

The perceived duration of time does not veridically reflect the physical duration but is distorted by various factors, such as the stimulus magnitude or the observer's emotional state. Here, we showed that knowledge about an event's termination time is another significant factor. We often experience time passage differently when we know that an event will terminate soon.

View Article and Find Full Text PDF
Article Synopsis
  • The study explores how the brain processes pitch, focusing on event-related potentials (ERPs) in response to sounds of varying frequencies, particularly looking at comparisons between musically-trained and non-trained individuals.
  • Participants listened to notes from the C major scale, revealing that brain responses varied significantly with pitch, showing anti-symmetric patterns between the left and right hemispheres.
  • Results indicated that musically-trained individuals had quicker and stronger brain responses to pitch changes, suggesting that musical training enhances the brain's ability to process and discriminate pitch frequencies more effectively.
View Article and Find Full Text PDF