Association between periodontal disease and malignant soft tissue sarcomas.

Objective: Malignant soft tissue sarcoma (MSTS) is a rare disease, but is seen in patients undergoing orthopedic surgery. Although the association of periodontal disease with various cancers occurring in the oral cavity, gastrointestinal tract, lungs, and prostate, has been reported, the association between periodontal disease and MSTS remains unclear. This study investigated the association between periodontal disease and MSTS in patients undergoing orthopedic surgery.

Surface-expressed phosphoglycerate mutase of Candida albicans binds to salivary DMBT1.

Candida albicans colonizes oral tissues and causes infectious diseases. Colonization of C. albicans on the oral mucosa and tooth enamel surfaces is established via the interaction between C.

Association of remaining tooth number with postoperative respiratory complications in heart valve surgery patients.

Objectives: This study examined the association between the number of remaining teeth and the incidence of postoperative respiratory complications in patients undergoing heart valve surgery.

Methods: We retrospectively enrolled 157 patients who underwent heart valve surgery between April 2010 and March 2019. Data on patient characteristics including systemic and oral conditions were extracted and postoperative respiratory complications were set as outcomes.

Comparison of methods for the handling of metallic dental restorations before head and neck radiotherapy.

Purpose: During head and neck radiotherapy, backscatter from metallic dental restorations (MDRs) causes oral mucositis. Currently, two MDR handling methods are used: the replacement of MDRs with provisional restorations (MDR removal) and fabrication of dental spacers before radiotherapy. We compared the effects of these two methods on the incidence of oral mucositis during head and neck radiotherapy.

A novel mannose-containing sialoprotein adhesin involved in the binding of Candida albicans cells to DMBT1.

Candida albicans colonizes the oral cavity and causes oral candidiasis and early childhood caries synergistically with cariogenic Streptococcus mutans. Colonization of oral tissues with C. albicans is an essential step in the initiation of these infectious diseases.

Perioperative Oral Management Prevents Complications of Heart Valve Surgery.

Objectives: The effect of perioperative oral management on the prevention of postoperative complications remains unclear in cardiac surgery. Exploratory factor analysis was performed to examine whether a lack of perioperative oral management was associated with postoperative complications of heart valve surgery.

Materials And Methods: We retrospectively enrolled 365 patients who underwent heart valve surgery between April 2010 and March 2019.

Effect of perioperative oral management on postoperative bloodstream infection in heart valve surgery patients.

Objective: There is a well-known relationship between oral hygiene and infective endocarditis. Epidemiological evidence regarding perioperative oral management (POM) for cancer surgery has been accumulated, but this evidence is not sufficient for cardiac surgery. Therefore, our purpose was to investigate whether POM can prevent postoperative complications in patients undergoing heart valve surgery.

A primary canine and an impacted permanent canine with infection potentially induced an intracranial abscess.

Intracranial abscess is a rare but life-threatening disease. There have been no reports on intracranial abscess induced by the residual primary tooth and the impacted successive permanent tooth with infection. We report on an interesting case of a 29-year-old man suffering from an epidural abscess, potentially caused by an infection of the residual primary maxillary right canine and the impacted permanent maxillary right canine.

Pathogenic mechanisms of cariogenic Propionibacterium acidifaciens.

Objective: Dental caries is one of the most common infectious diseases in humans. Older adults retain more teeth than did earlier generations and thus are at high risk of root caries. The root surface is covered by cementum, which facilitates the spread of caries lesions into dentinal tissues.

DMBT1 involvement in the human aortic endothelial cell response to Streptococcus mutans.

Streptococcus mutans is a causative organism of dental caries and has been reported to be associated with the development of cardiovascular disease (CVD). Previous studies have demonstrated that S. mutans invades human aortic endothelial cells (HAECs) and HAECs invaded by S.

Cross-cultural adaptation and psychometric properties of the Indonesia version of the self-efficacy oral health questionnaire for adolescents.

Background: Self-efficacy can be interpreted as a self-belief that one has successfully committed to a specific situation or maintained a specific behaviour.

Aim: We aimed to test the reliability and validity of a cross-cultural adaptation of the self-efficacy oral health (SEOH) questionnaire in the Indonesian language among adolescents and to understand the diverse perspectives of oral health self-efficacy related to gender.

Design: A cross-cultural adaptation of the SEOH self-administered questionnaire was completed followed by a dental caries examination.

Effect of perioperative oral care on prevention of postoperative pneumonia associated with esophageal cancer surgery: A multicenter case-control study with propensity score matching analysis.

The aim of this study was to investigate the effectiveness of oral care in prevention of postoperative pneumonia associated with esophageal cancer surgery.Postoperative pneumonia is a severe adverse event associated with esophageal cancer surgery. It is thought to be caused by aspiration of oropharyngeal fluid containing pathogens.

Impact of a 7-Day Field Training on Oral Health Condition in Japan Ground Self-Defense Force Personnel.

Introduction: In the Japan Ground Self-Defense Force (JGSDF), personnel periodically perform intensive training that mimics the conditions seen in battle and during natural disasters. Military training involves intensive, stressful conditions, and changes in immune responses have been found in personnel following training. Good oral condition is important for military personnel to fulfill their duties; however, they have difficulty performing daily oral care under training conditions.

Proper oral hygiene protocols decreased inflammation of gingivitis in a patient during chemotherapy with bevacizumab: a case report.

The case is a woman who had a diagnosis of ovarian cancer and endometrial cancer. After surgical therapy, platinum-based adjuvant treatment was performed, followed by additional bevacizumab administration. Because considerable gingivitis appeared, a proper approach for oral hygiene was performed.

Recombinant Sox Enzymes from Paracoccus pantotrophus Degrade Hydrogen Sulfide, a Major Component of Oral Malodor.

Hydrogen sulfide (HS) is emitted from industrial activities, and several chemotrophs possessing Sox enzymes are used for its removal. Oral malodor is a common issue in the dental field and major malodorous components are volatile sulfur compounds (VSCs), including HS and methyl mercaptan. Paracoccus pantotrophus is an aerobic, neutrophilic facultatively autotrophic bacterium that possesses sulfur-oxidizing (Sox) enzymes in order to use sulfur compounds as an energy source.

Preventive Effect on Post-Operative Pneumonia of Oral Health Care among Patients Who Undergo Esophageal Resection: A Multi-Center Retrospective Study.

Background: Post-operative pneumonia is a frequent and possibly fatal complication of esophagectomy and is likely caused by aspiration of oropharyngeal fluid that contains pathogenic micro-organisms. We conducted a multi-center retrospective study to investigate the preventive effect of oral health care on post-operative pneumonia among patients with esophageal cancer who underwent esophagectomy.

Methods: A total of 280 patients underwent esophagectomy at three university hospitals.

Invasive Streptococcus mutans induces inflammatory cytokine production in human aortic endothelial cells via regulation of intracellular toll-like receptor 2 and nucleotide-binding oligomerization domain 2.

Streptococcus mutans, the primary etiologic agent of dental caries, can gain access to the bloodstream and has been associated with cardiovascular disease. However, the roles of S. mutans in inflammation in cardiovascular disease remain unclear.

Purification of a novel fibronectin binding protein from 'Granulicatella para-adiacens'.

The interaction of microorganisms with fibronectin plays an important role in infective endocarditis. Characterization of fibronectin binding is not sufficient for nutritionally variant streptococci (NVS), which is an important pathogen associated with this disease. In this study, we identified and purified the novel fibronectin binding protein (FBP) by sonication and column chromatography from a ' Granulicatella para-adiacens' strain isolated from the oral cavity of a healthy donor.

Oral Fusobacterium nucleatum subsp. polymorphum binds to human salivary α-amylase.

Fusobacterium nucleatum acts as an intermediate between early and late colonizers in the oral cavity. In this study, we showed that F. nucleatum subsp.

Staphylococcus aureus SasA is responsible for binding to the salivary agglutinin gp340, derived from human saliva.

Staphylococcus aureus is a major human pathogen that can colonize the nasal cavity, skin, intestine, and oral cavity as a commensal bacterium. gp340, also known as DMBT1 (deleted in malignant brain tumors 1), is associated with epithelial differentiation and innate immunity. In the oral cavity, gp340 induces salivary aggregation with several oral bacteria and promotes bacterial adhesion to tissues such as the teeth and mucosa.

Streptococcus oralis coaggregation receptor polysaccharides induce inflammatory responses in human aortic endothelial cells.

Streptococcus oralis, belonging to the oral viridans group streptococci, has been detected in human cardiovascular lesions including infective endocarditis and atheromatous plaques. The organism has coaggregation receptor polysaccharides (RPS) on the cell wall, which function as receptors for surface adhesins on other members of the oral biofilm community. The present study examined the capacity of S.

GlmS and NagB regulate amino sugar metabolism in opposing directions and affect Streptococcus mutans virulence.

Streptococcus mutans is a cariogenic pathogen that produces an extracellular polysaccharide (glucan) from dietary sugars, which allows it to establish a reproductive niche and secrete acids that degrade tooth enamel. While two enzymes (GlmS and NagB) are known to be key factors affecting the entrance of amino sugars into glycolysis and cell wall synthesis in several other bacteria, their roles in S. mutans remain unclear.

Effect of saliva viscosity on the co-aggregation between oral streptococci and Actinomyces naeslundii.

Background: The co-aggregation of oral bacteria leads to their clearance from the oral cavity. Poor oral hygiene and high saliva viscosity are common amongst the elderly; thus, they frequently suffer from pneumonia caused by the aspiration of oral microorganisms.

Objectives: To examine the direct effect of saliva viscosity on the co-aggregation of oral streptococci with actinomyces.

Identification and characterization of a fibronectin-binding protein from Granulicatella adiacens.

The interaction of microorganisms with fibronectin plays an important role in infective endocarditis. Granulicatella adiacens is a member of the oral microbiota, formerly known as nutritionally variant streptococci, and is often isolated from endocarditis patients. In the present study we identified a surface protein, designated Cha, which binds to fibronectin, by a plaque hybridization procedure using the cshA sequence as probe, which encodes a fibronectin-binding molecule of Streptococcus gordonii DL1.

Streptococcus anginosus l-cysteine desulfhydrase gene expression is associated with abscess formation in BALB/c mice.

Streptococcus anginosus, an anginosus group bacterium, is frequently isolated from odontogenic abscesses, and is the oral bacterium that is primarily responsible for producing hydrogen sulfide from l-cysteine through the action of its l-cysteine desulfhydrase (βC-S lyase) enzyme. However, the relationship between its production of hydrogen sulfide and abscess formation has not been investigated. To elucidate the etiological role of hydrogen sulfide in abscess formation, we initially measured, using specific primers, expression of the lcd gene, which encodes βC-S lyase, in the pus of abscesses that formed in BALB/c mice following subcutaneous injection of S.