Histamine release and hypotensive reactions in dogs by solubilizing agents and fatty acids: analysis of various components in cremophor El and development of a compound with reduced toxicity.

Anaphylactoid reactions in man following administration of drugs solubilized with cremophor El (polyethylenglycolglycerol riconoleate) are a considerable clinical problem. Since these reactions occur in dogs on first exposure and in pigs on second exposure, the 'dog model' was used in this communication to analyse components and chemical modifications of cremophor El and its components for their clinical effects, their hypotensive actions and their histamine-releasing capacity. Two series of experiments in 1978 and 1980 were performed in 144 adult mongrel dogs of both sexes.

Intestinal diamine oxidase and histamine release in rabbit mesenteric ischemia.

It has been suggested that histamine contributes to lethal circulatory collapse after acute superior mesenteric artery occlusion. The activity of the histamine inactivating enzyme diamine oxidase, the release of the amine, and the effect of histamine receptor antagonists was therefore studied in rabbits. The main results were: (a) Diamine oxidase activity decreased by 60% after intestinal ischemia and reperfusion.

[A clinical study of co2-elimination using a modified bain-system (author's transl)].

Of three groups of anaesthetized and intubated patients (n = 7) under controlled ventilation two received fresh gas flows of 70 ml/kg . min, 100 ml/kg . min and 130 ml/kg .

[Effect of planned treatment policy in patients with upper gastrointestinal bleeding using endoscopic neodymium-YAG laser therapy (author's transl)].

In a prospective trial with and without laser therapy the outcome on 105 patients was evaluated according to a defined protocol and terminology. Only patients with actively bleeding lesions during early endoscopy had laser therapy. Patients showing evidence of recent bleeding or no bleeding had none.