Saccadic selection in visual working memory is robust across the visual field and linked to saccade metrics: Evidence from nine experiments and more than 100,000 trials.

Visual working memory and actions are closely intertwined. Memory can guide our actions, but actions also impact what we remember. Even during memory maintenance, actions such as saccadic eye movements select content in visual working memory, resulting in better memory at locations that are congruent with the action goal as compared to incongruent locations.

Visual short-term memory-related EEG components in a virtual reality setup.

Virtual reality (VR) offers a powerful tool for investigating cognitive processes, as it allows researchers to gauge behaviors and mental states in complex, yet highly controlled, scenarios. The use of VR head-mounted displays in combination with physiological measures such as EEG presents new challenges and raises the question whether established findings also generalize to a VR setup. Here, we used a VR headset to assess the spatial constraints underlying two well-established EEG correlates of visual short-term memory: the amplitude of the contralateral delay activity (CDA) and the lateralization of induced alpha power during memory retention.

Codevelopment of an illustration representative of people living with spina bifida for health educational materials.

Background: The lack of health education resources specific to people with disabilities contributes to disparities in outcomes. Developing user-centered materials with representative images tailored to people with disabilities could help improve knowledge and outcomes.

Objective: As a first step in developing an online sexual health resource for adolescents with physical disabilities, we sought end-user feedback to create illustrated characters for use in educational materials.

Sphingosine-1-Phosphate Recruits Macrophages and Microglia and Induces a Pro-Tumorigenic Phenotype That Favors Glioma Progression.

Glioblastoma is the most aggressive brain tumor in adults. Treatment failure is predominantly caused by its high invasiveness and its ability to induce a supportive microenvironment. As part of this, a major role for tumor-associated macrophages/microglia (TAMs) in glioblastoma development was recognized.

Moving fast and seeing slow? The visual consequences of vigorous movement.

In active agents, sensory and motor processes form an inevitable bond. This wedding is particularly striking for saccadic eye movements - the prime target of Shadmehr and Ahmed's thesis - which impose frequent changes on the retinal image. Changes in movement vigor (latency and speed), therefore, will need to be accompanied by changes in visual and attentional processes.

Antisense oligonucleotides and nucleic acids generate hypersensitive platelets.

Introduction: Despite the great promise for therapies using antisense oligonucleotides (ASOs), their adverse effects, which include pro-inflammatory effects and thrombocytopenia, have limited their use. Previously, these effects have been linked to the phosphorothioate (PS) backbone necessary to prevent rapid ASO degradation in plasma. The main aim of this study was to assess the impact of the nucleic acid portion of an ASO-type drug on platelets and determine if it may contribute to thrombosis or thrombocytopenia.

Adipokines and Autoimmunity in Inflammatory Arthritis.

Adipokines are adipose tissue-derived factors not only playing an important role in metabolism but also influencing other central processes of the body, such as inflammation. In autoimmune diseases, adipokines are involved in inflammatory pathways affecting different cell types. Many rheumatic diseases belong to the group of autoimmune diseases, for example rheumatoid arthritis (RA) and psoriatic arthritis.

Optimized Protocol for Isolation of Small Extracellular Vesicles from Human and Murine Lymphoid Tissues.

Small extracellular vesicles (sEVs) are nanoparticles responsible for cell-to-cell communication released by healthy and cancer cells. Different roles have been described for sEVs in physiological and pathological contexts, including acceleration of tissue regeneration, modulation of tumor microenvironment, or premetastatic niche formation, and they are discussed as promising biomarkers for diagnosis and prognosis in body fluids. Although efforts have been made to standardize techniques for isolation and characterization of sEVs, current protocols often result in co-isolation of soluble protein or lipid complexes and of other extracellular vesicles.

Bold moves: Inevitable saccadic selection in visual short-term memory.

Selection for visual short-term memory (vstm) provides a basis for many cognitive functions. Saccadic eye movements sway this selection in favor of stimuli previously seen at locations congruent with their target. In three experiments, we provide converging evidence that this saccadic selection is implemented as a fundamental, inevitable selection process, rather than a top-down strategy.

Dissecting the Prognostic Significance and Functional Role of Progranulin in Chronic Lymphocytic Leukemia.

Chronic lymphocytic leukemia (CLL) is known for its strong dependency on the tumor microenvironment. We found progranulin (GRN), a protein that has been linked to inflammation and cancer, to be upregulated in the serum of CLL patients compared to healthy controls, and increased GRN levels to be associated with an increased hazard for disease progression and death. This raised the question of whether GRN is a functional driver of CLL.

Active information sampling varies across the cardiac cycle.

Perception and cognition oscillate with fluctuating bodily states. For example, visual processing has been shown to change with alternating cardiac phases. Here, we study the heartbeat's role for active information sampling-testing whether humans implicitly act upon their environment so that relevant signals appear during preferred cardiac phases.

Saccadic selection of stabilized items in visuospatial working memory.

Saccadic eye movements prioritize the memory of visual stimuli that had previously been seen at the saccade target. In two experiments, we assessed whether this influence is limited to fragile memory traces or if saccades can also affect consolidated representations in visuospatial working memory (VSWM). To interfere with fragile memory traces, we presented visual masks at different delays following the offset of a memory array and simultaneously prompted participants to generate a saccade to one location.

Tele-Immersion Concepts.

Tele-immersive systems development is always driven as well as restricted by the available immersive technology. Hence, existing such systems are described mainly from a technological point of view; their conceptual description is usually limited to the description of a scenario that is implementable with or circumvents the limitations of the chosen technology. This focus on technology makes it difficult to compare systems' concepts; moreover, it has led to different views on tele-immersion in different fields, such as remotely controlled robots, immersive video conferencing, and tele-collaboration.

Chances and challenges for an active visual search perspective.

Using fixations as the fundamental unit of visual search is an appealing gear change in a paradigm that has long dominated attention research. To truly inform theories of search, however, additional challenges must be faced, including (1) an empirically motivated definition of fixation in the presence of fixational saccades and (2) the biases and limitations of transsaccadic perception and memory.

Tumor necrosis factor receptor signaling is a driver of chronic lymphocytic leukemia that can be therapeutically targeted by the flavonoid wogonin.

Chronic lymphocytic leukemia is a malignancy of mature B cells that strongly depend on microenvironmental factors, and their deprivation has been identified as a promising treatment approach for this incurable disease. Cytokine array screening of 247 chronic lymphocytic leukemia serum samples revealed elevated levels of tumor necrosis factor (TNF) receptor-1 which were associated with poor clinical outcome. We detected a microenvironment-induced expression of TNF receptor-1 in chronic lymphocytic leukemia cells , and an aberrantly high expression of this receptor in the proliferation centers of patients' lymph nodes.

Selective enhancement of orientation tuning before saccades.

Saccadic eye movements cause a rapid sweep of the visual image across the retina and bring the saccade's target into high-acuity foveal vision. Even before saccade onset, visual processing is selectively prioritized at the saccade target. To determine how this presaccadic attention shift exerts its influence on visual selection, we compare the dynamics of perceptual tuning curves before movement onset at the saccade target and in the opposite hemifield.

Saccadic eye movements impose a natural bottleneck on visual short-term memory.

Visual short-term memory (VSTM) is a crucial repository of information when events unfold rapidly before our eyes, yet it maintains only a fraction of the sensory information encoded by the visual system. Here, we tested the hypothesis that saccadic eye movements provide a natural bottleneck for the transition of fragile content in sensory memory to VSTM. In 4 experiments, we show that saccades, planned and executed after the disappearance of a memory array, markedly bias visual memory performance.

Lithotripter shock wave interaction with a bubble near various biomaterials.

Following previous work on the dynamics of an oscillating bubble near a bio-material (Ohl et al 2009 Phys. Med. Biol.

Revealing the time course of signals influencing the generation of secondary saccades using Aalen's additive hazards model.

Saccadic eye movements are frequently followed by smaller secondary saccades which are generally assumed to correct for the error in primary saccade landing position. However, secondary saccades can also occur after accurate primary saccades and they are often as small as microsaccades, therefore raising the need to further scrutinize the processes involved in secondary saccade generation. Following up a previous study, we analyzed secondary saccades using rate analysis which allows us to quantify experimental effects as shifts in distributions, therefore going beyond comparisons of mean differences.

Setting and changing feature priorities in visual short-term memory.

Many everyday tasks require prioritizing some visual features over competing ones, both during the selection from the rich sensory input and while maintaining information in visual short-term memory (VSTM). Here, we show that observers can change priorities in VSTM when, initially, they attended to a different feature. Observers reported from memory the orientation of one of two spatially interspersed groups of black and white gratings.

Saccadic adaptation to a systematically varying disturbance.

Saccadic adaptation maintains the correct mapping between eye movements and their targets, yet the dynamics of saccadic gain changes in the presence of systematically varying disturbances has not been extensively studied. Here we assessed changes in the gain of saccade amplitudes induced by continuous and periodic postsaccadic visual feedback. Observers made saccades following a sequence of target steps either along the horizontal meridian (Two-way adaptation) or with unconstrained saccade directions (Global adaptation).

Microsaccades Are Coupled to Heartbeat.

Unlabelled: During visual fixation, the eye generates microsaccades and slower components of fixational eye movements that are part of the visual processing strategy in humans. Here, we show that ongoing heartbeat is coupled to temporal rate variations in the generation of microsaccades. Using coregistration of eye recording and ECG in humans, we tested the hypothesis that microsaccade onsets are coupled to the relative phase of the R-R intervals in heartbeats.

Latency in Distributed Acquisition and Rendering for Telepresence Systems.

Telepresence systems use 3D techniques to create a more natural human-centered communication over long distances. This work concentrates on the analysis of latency in telepresence systems where acquisition and rendering are distributed. Keeping latency low is important to immerse users in the virtual environment.

Bubbles with shock waves and ultrasound: a review.

The study of the interaction of bubbles with shock waves and ultrasound is sometimes termed 'acoustic cavitation'. It is of importance in many biomedical applications where sound waves are applied. The use of shock waves and ultrasound in medical treatments is appealing because of their non-invasiveness.

Compensatory eye and head movements of patients with homonymous hemianopia in the naturalistic setting of a driving simulation.

Homonymous hemianopia (HH) is a frequent deficit resulting from lesions to post-chiasmal brain structures with a significant negative impact on activities of daily living. To address the question how patients with HH may compensate their visual field defect in a naturalistic environment, we performed a driving simulation experiment and quantitatively analyzed both eye and head movements using a head-mounted pupil camera. 14 patients with HH and 14 matched healthy control subjects participated in the study.