Publications by authors named "Oguzhan Kavrik"
Article Synopsis
- The study investigates the neuroprotective effects of Thymoquinone (TQ) and Metformin (MM) on Parkinson's disease by testing their effects separately and in combination on mice.* -
- Mice treated with TQ, MM, or both showed significant improvements in motor coordination and reduced markers of oxidative stress and neurodegeneration compared to the control group.* -
- Findings suggest that TQ and MM together may be more effective than either alone, providing evidence for their potential as a therapy for Parkinson's disease.*
Article Synopsis
- The study explored the effects of Vetiveria zizanioides oil (VET) on oxidative stress and cell death in rats that experienced seizures induced by pentylenetetrazol (PTZ).
- Four groups of rats were observed: a control group, a PTZ only group, and two groups receiving different doses of VET alongside the PTZ treatment.
- Findings indicated that PTZ increased seizure activity and caused oxidative stress, but treatment with VET significantly reduced these negative effects and improved the overall condition of the rats' brain tissues.
Article Synopsis
- The study explores how high fructose corn syrup (HFCS) negatively impacts memory and learning by impairing activity in the prefrontal cortex (PFC) of adolescent rats.
- Rats were divided into three groups: a control group, an HFCS group, and an HFCS plus vitamin D group, with various tests conducted to assess fluid intake, weight gain, and behavioral performance.
- Results showed that HFCS increased neuron degeneration and impaired memory functions, while vitamin D treatment reversed these negative effects, enhancing cholinergic activity and improving learning and memory.
Protective effect of pregabalin on renal and renal endothelial damage in sepsis induced by lipopolysaccharide.
Immunopharmacol Immunotoxicol
February 2024
Article Synopsis
- The study aimed to evaluate the protective role of pregabalin (PRG) against kidney and renal endothelial damage caused by sepsis induced by lipopolysaccharide (LPS) in rats.
- Results showed that LPS significantly worsened kidney function markers and increased oxidative stress, while adding PRG improved these markers and reduced inflammation and tissue damage.
- The findings suggest that PRG may help mitigate sepsis-related kidney damage and indicate potential for its use in preventive treatment, although further research is needed.
Objectives: We investigated the harmful effects of high fructose corn syrup (HFCS) on learning and memory in the hippocampus and the ameliorative effects of melatonin (Mel).
Materials And Methods: Thirty-six adult male Sprague Dawley rats were divided into three groups: Group I, control; Group II, HFCS; and Group III, HFCS+Mel. HFCS form F55 was prepared as a 20% fructose syrup solution.