Method development and validation for determination of N-Nitrosamines in pharmaceutical preparations by LC-MS/MS: Application to extractables and leachables studies.

The use of highly sensitive and reliable analytical methods is essential for Extractables & Leachables studies. Especially the determination of N-Nitrosamines in drugs, which have carcinogenic properties and may contaminate drugs at trace levels, is quite important. In this study, a new, sensitive, short-time and reliable liquid chromatography with tandem mass spectrometry method was developed for the analysis of 15 N-Nitrosamines defined in the European Pharmacopoeia within the scope of Extractables & Leachables studies and validated according to the International Council for Harmonization (ICH Q2 (R2)).

Regioselective C3-H Alkylation of Imidazopyridines with Donor-Acceptor Cyclopropanes.

Alkylated imidazopyridines are crucial structures for medicinal chemistry. Here, an efficient method for the C3-H alkylation of imidazopyridines was devised. Under Lewis acid-catalyzed conditions, reactions of imidazopyridines with different donor-acceptor cyclopropanes were carried out.

An AIE active fluorescence sensor for measuring Fe in aqueous media and an iron deficiency anemia drug.

In this study, a new tetraphenylethene derivative bearing triazole and pyridine moieties (TPE-TAP) was synthesized using click chemistry. The fluorescence sensing properties of TPE-TAP were investigated in almost 100% aqueous media. For this purpose, first of all, structural characterization of the newly synthesized compound TPE-TAP was performed by NMR and HRMS analyses.