Publications by authors named "Ogorodova L"
The study of the influence of nutrition and its associations with other parameters, which are closely related to the metabolic profile, in order to better understand the mechanisms of realization of the obesity phenotype in the child population is of particular interest. of the study was to investigate the eating habits of elementary school children and their dependence on the parameters of physical development and body composition of the child population of Tomsk. .
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- The surface architecture of nanoparticles, influenced by ligand modifications and protein interactions in biofluids, is essential for their cellular interactions in living organisms.
- In this study, we examined how immune cells interact with magnetic nanoparticles modified with polyethylene glycol (PEG) and peptide ligands, discovering that pHLIP modification improved their uptake by immune cells compared to cycloRGD.
- Although we didn't find notable differences in protein corona composition between the modified and unmodified nanoparticles, variations in nanoparticle uptake were observed among different individuals, highlighting the need to consider personal differences in serum during nanotherapy testing.
Background: Cholangiocarcinoma (CCA), a fatal bile duct cancer, has a high incidence in Western Siberia, Russian Federation. In addition, Opisthorchis felineus, a bile duct-dwelling trematode liver fluke is highly endemic. Closely related species have been shown to be cancerogenic agents in Asia.
View Article and Find Full Text PDFIn Russia, a universal varicella vaccination (UVV) program has not been implemented, and varicella vaccination coverage is low. We assessed the efficacy, antibody persistence, and safety of one- and two-dose varicella vaccination schedules in Russian children with a ten-year follow-up period, as part of an international phase IIIB, observer-blind, randomized, controlled trial (NCT00226499). Children aged 12-22 months were randomized (3:3:1) to receive two doses of tetravalent measles-mumps-rubella-varicella vaccine (V2 group), one dose trivalent measles-mumps-rubella (MMR) vaccine and one dose of varicella vaccine (V1 group), or two doses of MMR vaccine (V0 [control] group), 42 days apart.
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- Researchers created innovative organosilicon MNPs modified with pHLIP and PEG, showing enhanced specificity and low cytotoxicity in vitro, particularly at acidic pH levels.
- The study revealed that these pHLIP-modified MNPs accumulated significantly more in tumors compared to standard PEGylated MNPs in mouse models, indicating their potential for better cancer imaging.
The presence of some species of helminths is associated with changes in host microbiota composition and diversity, which varies widely depending on the infecting helminth species and other factors. We conducted a prospective case-control study to evaluate the gut microbiota in children with Opisthorchis felineus infection (n=50) before and after anthelmintic treatment and in uninfected children (n=49) in the endemic region. A total of 99 children and adolescents aged between 7 and 18 years were enrolled to the study.
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- The study examines how the acidic environment of tumors affects the delivery of magnetic nanoparticles (MNPs) modified with a peptide that responds to low pH levels.
- Researchers found that these pHLIP-conjugated MNPs were more effective at targeting cancer cells in acidic conditions (pH 6.4) compared to neutral (pH 7.2).
- Results indicated a correlation between the acidity of the tumor microenvironment and the accumulation of MNPs, suggesting the potential for personalized treatment strategies based on tumor pH profiles.
Background: The liver fluke, Opisthorchis felineus, is widely distributed throughout Europe and large parts of the Russian Federation. In Western Siberia, information about opisthorchiasis is lacking although infection may lead to severe liver and bile duct diseases. We aimed to assess the current prevalence of O.
View Article and Find Full Text PDFBackground: A clear understanding of the differences in the epidemiology of food allergy between rural and urban populations may provide insights into the causes of increasing prevalence of food allergy in the developed world.
Objective: We used a standardized methodology to determine the prevalence and types of food-specific allergic sensitization and food allergies in schoolchildren from urban and rural regions of China, Russia, and India.
Methods: The current study is a multicenter epidemiological survey of children recruited from 5 cities in China (Hong Kong and Guangzhou), Russia (Tomsk), and India (Bengaluru and Mysore) and 1 rural county in Southern China (Shaoguan).
Article Synopsis
- Biological systems influence nanoparticle delivery in tumors more than the design of the nanoparticles themselves.
- The study focuses on the delivery of FeO magnetic nanoparticles (MNP-pHLIP) in human breast cancer models, revealing that their accumulation correlates with the tumor's volume.
- Findings indicate that the distribution of blood vessels within the tumor plays a crucial role in how effectively these nanoparticles can accumulate in the tumor tissue.
Article Synopsis
- The study examines how liver fluke infection (Opisthorchis felineus) induces chronic oxidative stress, leading to significant disruptions in the hepatic glutathione system, which is essential for detoxifying harmful reactive oxygen species (ROS).
- Chronic infection results in decreased levels of the protective form of glutathione (GSH), lower GSH/GSSG ratios, and reduced enzyme activities that help manage oxidative damage, ultimately causing hepatocellular harm and liver fibrosis.
- Treatments with N-acetylcysteine (NAC) and l-buthionine-S, R-sulfoxinine (BSO) can modify glutathione levels in infected livers, influencing collagen content and fibrosis severity, highlighting the glutath
Cholangiocarcinoma (CCA) is a cancer with high mortality owing to its aggressiveness and resistance to therapy. The liver flukes of the Opisthorchiidae family have been recognized as risk factors of CCA. infection occurs in Western Siberia, the biggest endemic area in the Russian Federation, and is associated with chronic inflammation of the bile ducts, which may be linked to severe hepatobiliary morbidity.
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- * It was found that the best modification conditions involved a reaction at 40 °C with an equimolar amount of PMIDA for 3.5 hours, resulting in good colloidal stability and high magnetic properties of the MNPs.
- * The PMIDA-modified MNPs showed superior performance with relaxivity values of 341 and 102 mmol s, and were successfully tested as a T1 contrast agent for liver imaging in vivo, indicating their potential medical application.
We examined common variation in asthma risk by conducting a meta-analysis of worldwide asthma genome-wide association studies (23,948 asthma cases, 118,538 controls) of individuals from ethnically diverse populations. We identified five new asthma loci, found two new associations at two known asthma loci, established asthma associations at two loci previously implicated in the comorbidity of asthma plus hay fever, and confirmed nine known loci. Investigation of pleiotropy showed large overlaps in genetic variants with autoimmune and inflammatory diseases.
View Article and Find Full Text PDFIn this study we reviewed Russian scientific literature (scientific publications, book chapters, monographs) published between 1 January 1979 and 31 August 2015 from two sources: Main database of the Russian Scientific Electronic Library (eLIBRARY, http://elibrary.ru/), and the Scientific Medical Library of Siberian State Medical University (http://medlib.tomsk.
View Article and Find Full Text PDFBackground: Opisthorchiasis is a parasitic infection caused by the liver flukes of the Opisthorchiidae family. Both experimental and epidemiological data strongly support a role of these parasites in the etiology of the hepatobiliary pathologies and an increased risk of intrahepatic cholangiocarcinoma. Understanding a functional link between the infection and hepatobiliary pathologies requires a detailed description a host-parasite interaction on different levels of biological regulation including the metabolic response on the infection.
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- The European liver fluke, Opisthorchis felineus, causes serious health issues like opisthorchiasis and bile duct cancer, particularly in certain regions of Europe and Central Asia, often going unnoticed due to a lack of specific symptoms.
- Researchers utilized in vivo magnetic resonance imaging (MRI) and spectroscopy (MRS) to assess liver damage caused by O. felineus in experimental animals, finding distinctive MR patterns and correlations with histological and biochemical liver data.
- MRI emerges as a promising non-invasive diagnostic tool for evaluating liver impairment and metabolic changes related to O. felineus infection, potentially improving the detection and understanding of liver fibrosis without the complications of liver biopsy.
Background: Genome-wide association studies have identified novel genetic associations for asthma, but without taking into account the role of active tobacco smoking. This study aimed to identify novel genes that interact with ever active tobacco smoking in adult onset asthma.
Methods: We performed a genome-wide interaction analysis in six studies participating in the GABRIEL consortium following two meta-analyses approaches based on 1) the overall interaction effect and 2) the genetic effect in subjects with and without smoking exposure.
Background: Most studies on the relationship between helminth infections and atopic disorders have been conducted in (sub)tropical developing countries where exposure to multiple parasites and lifestyle can confound the relationship. We aimed to study the relationship between infection with the fish-borne helminth Opishorchis felineus and specific IgE, skin prick testing, and atopic symptoms in Western Siberia, with lifestyle and hygiene standards of a developed country.
Methods: Schoolchildren aged 7-11 years were sampled from one urban and two rural regions.
Article Synopsis
- Liver fluke infection can severely damage the liver but is often overlooked due to unclear symptoms; nanoparticle-enhanced MRI could help detect related liver lesions effectively.
- Researchers modified iron oxide nanoparticles using 3-aminopropylsilane (APS) and analyzed their properties through various techniques to confirm structural integrity and enhance their magnetic capabilities for imaging.
- The study found that these APS-modified nanoparticles can be used as a contrast agent in MRI, showing promising results for diagnosing liver damage caused by liver flukes with minimal toxicity to cells.
Opisthorchis felineus (O. felineus) occurs in Western Siberia and many other parts of the Russian Federation (RF). The true extent of its distribution is not known.
View Article and Find Full Text PDFBackground: There is increasing interest in the microbiome of the hepatobiliary system. This study investigated the influence of infection with the fish-borne liver fluke, Opisthorchis felineus on the biliary microbiome of residents of the Tomsk region of western Siberia.
Methodology/principal Findings: Samples of bile were provided by 56 study participants, half of who were infected with O.
Background: Data are lacking regarding the prevalence of food sensitization and probable food allergy among general population in India. We report the prevalence of sensitization and probable food allergy to 24 common foods among adults from general population in Karnataka, South India.
Methodology: The study was conducted in two stages: a screening study and a case-control study.
Identification of a new locus at 16q12 associated with time to asthma onset.
J Allergy Clin Immunol
October 2016
Background: Asthma is a heterogeneous disease in which age of onset plays an important role.
Objective: We sought to identify the genetic variants associated with time to asthma onset (TAO).
Methods: We conducted a large-scale meta-analysis of 9 genome-wide association studies of TAO (total of 5462 asthmatic patients with a broad range of age of asthma onset and 8424 control subjects of European ancestry) performed by using survival analysis techniques.