[Prognosis factors in imatinib mesilate therapy in patients with a chronic phase of Ph-positive chronic myeloid leukemia: data from a multicenter non-randomized trial in Russia].

Aim: To reveal prognostically significant factors affecting efficacy of glivek therapy in untreated (duration of the disease < or = 6 months) and pretreated (duration of the disease > 6 months) patients with chronic myeloid leukemia (CML) in a chronic phase.

Material And Methods: A total of 338 patients (64 untreated and 274 pretreated) with a chronic-phase CML on glivek therapy entered the trial.

Results: Five-year survival on glivek was high (89, 98 and 88% in untreated and pretreated patients, respectively).

[Gastritis associated with Helicobacter pylori in the material of gastrobiopsies in the group of children with dyspepsia].

Helicobacter pylori (HP) was studied in gastrobiopsies from 180 children, 9 to 17 years old with chronic dyspeptic symptoms. The presence of HP was found in the stomach mucosa of 78.9% patients.

Helicobacter pylori infection and reflux esophagitis in children with chronic asthma.

Background: Reflux esophagitis is uncommon in countries in which most people are colonized by H. pylori infection and is extremely rare in persons with reflux esophagitis, although esophagitis is detected in almost 50% of children with recurrent lower respiratory tract symptoms.

Hypothesis: Failure to acquire H.

[The effectiveness of interferon-alpha therapy in Ph-positive chronic myeloid leukemia].

Chronic myeloid leukemia (CML) is a hemopoietic condition caused by chromosomal translocation t(9;22)(q34;q11) or bcr-abl fusion gene. The predominant variants of bcr-abl oncogene rearrangement are b3a2 and b2a2. The present study evaluated the efficacy of interferon-a therapy of CML patients and molecular prognostic factors.

[Detection of chromosome translocation t(9;22) using RT-PCR].

The investigation deals with a simplified modification or molecular-genetic detection of translocation t(9;22) using a combination of reverse transcription and polymerase chain reactions (RT-PCR). Unlike the available protocols, analysis is carried out using one enzyme--TET-Z polymerase--(instead of two) which has both revertase and DNA-polymerase activities. The present modification is highly sensitive, less time-consuming and cheaper.

[Possible pleurogenic route in the development of bronchiectasis in children].

Chronic pneumonia with bronchiectases develops often after acute destructive pneumonia with pleurogenous complications. This process is attributed to infection of the pleural adhesions, disorders of pleuropulmonary circulation of blood and lymph, and changes of the rhythmic activity of the bronchi. Study of the motor activity of the smooth-muscle structures of the wall of bronchi involved in a chronic process disclosed sharply diminished tonus and activity of biopotentials.

[Ultrastructural changes in ovarian tumor cancer cells under the influence of preoperative chemotherapy].

Studies of ultrastructural changes in cancerous cells of tumours of the ovaries in patients who had undergone preoperative chemotherapy, and the ultrastructural organization of cancerous cells of the overies in patients who had received no such treatment were carried out. Comparisons of the data obtained were made. It is established that preoperative chemotherapy brought about changes both in the nucleus and in cytoplasma of the cancerous cells.