Epidermal growth factor receptor gene copy number changes in lung cancer.

Objective: The objective of this study was to assess the implication of copy number changes of epidermal growth factor receptor (EGFR) in lung cancer pathogenesis.

Materials And Methods: We used the highly reliable method of FISH, applied on tissue microarray (TMA), containing 306 lung tumors of different histological types, grades and tumor stage, in order to analyze the correlations between gene copy number changes and tumor phenotype.

Results: The frequency of EGFR copy number changes was 22.