A dedicated screening program for geriatric HIV-infected patients integrating HIV and geriatric care.

Background: Clinicians caring for HIV-infected patients >60 years old encounter multiple clinical challenges. The use of a functional geriatrics screening for detection of significant comorbidities is important in this population.

Methods: The geriatrics screening evaluated functional capabilities, depression, cognitive dysfunction, nutrition, mobility, medicines used, and interactions.

Protein binding and ivermectin estimations in patients with onchocerciasis.

We measured ivermectin in plasma, urine, and saliva of nine patients with onchocerciasis. The aim was to establish pharmacokinetic parameters and to assess the most facile medium for use in monitoring compliance. Binding of ivermectin to plasma proteins in vitro was also investigated.

Ivermectin levels in human breastmilk.

Ivermectin levels were measured in breastmilk and plasma of 4 healthy mothers after an oral 150 micrograms/kg dose. Mean +/- S.D.

Studies on onchocerciasis in forest-savannah mosaic areas of Nigeria. I. Investigations in Gbaragu, Oji River.

Reports on onchocerciasis in Nigeria have been scanty, despite the size of the country and of the problem. A survey of the prevalence and transmission of the disease in the south-eastern communities of Nigeria was commenced, with a year-long study of the vector and the clinical manifestations of the disease in a forest-savannah mosaic area on the Oji river. Microfilaraemia was found in 76% of the population, and nodules in 62%; there were no significant differences between male and female prevalence rates.

Plasma levels of chloroquine in healthy Nigerian children: clinical and toxicological implications.

1. Sixteen healthy children attending the Well Baby Clinic of the University of Nigeria Teaching Hospital, Enugu were studied. 2.

Ivermectin binds avidly to plasma proteins.

Human pharmacokinetic data on the new anti-parasitic agent, ivermectin, are scanty. For the evaluation of its disposition a specific HPLC assay with sensitive fluorescence detection was developed. Applying equilibrium dialysis, plasma protein binding of ivermectin was measured in five healthy individuals and it averaged 93.

Self-monitoring of blood pressures in hypertensive subjects and its effects on patient compliance.

This study investigated the effects, if any, that teaching hypertensive patients to take their own blood pressures, as well as education and counseling, would have on compliance. Prior to the initiation of the study, the pharmacist-investigator collected data on the hypertension clinic as it traditionally functioned. This preliminary investigation included studying the work flow of the clinic and reviewing medical records to determine who among the clinic registrants met the criteria set up for inclusion in this study.