Publications by authors named "Ogbonna Okorie"
Objective: To investigate antinociceptive and anti-inflammatory activities of crude extract from Ipomoea involucrata leaves (Convolvulaceae) in mice and rats.
Methods: The antinociceptive activity was tested using acetic acid-induced abdominal writhing test in mice. The anti-inflammatory activity was evaluated using egg albumin induced oedema of rat paw.
Background: Considering the cost of acquiring a liquid chromatographic instrument in underdeveloped economies, the rising incidence of diabetes mellitus, the need to evaluate the quality performance of glimepiride generics, and the need for less toxic processes, this research is an imperative.
Methods: The method was validated for linearity, recovery accuracy, intra- and inter-day precision, specificity in the presence of excipients, and inter-day stability under laboratory conditions. Student's t test at the 95% confidence limit was used for statistics.
Article Synopsis
- Researchers extracted soluble mucus glycoprotein (S-mucin) from pig intestines and combined it with type B gelatin to create cefaclor-loaded microspheres, using emulsification and crosslinking methods.
- The microspheres showed strong mucoadhesive properties, with cefaclor release being significantly higher and quicker in simulated gastric fluid compared to simulated intestinal fluid, and more effective when mixed with S-mucin.
- The study suggests that the rectal route for delivering cefaclor could be a viable alternative to oral administration, and that careful formulation can lead to targeted delivery to the small intestine, enhancing the drug's bioavailability.