Publications by authors named "Oganesian V"

Using an automated laser-fiber spectrofluorimeter, the fluorescence spectra of normal and malignant tissues sensibilized by chlorin e6 and flurenate in vivo and ex vivo were studied. A quenching of intrinsic fluorescence of sensibilized tissues was found, which was more evident in the affected regions. The observed effect is related to electron excitation energy transfer from endogenous fluorophores to the photosensitizers administered.

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Fluorescence and photodynamic destruction of tumor tissues containing hematoporphyrin derivative was studied during excitation by II and III harmonics of AY:Nd(3+)-laser. This laser system can be effectively used for diagnosis of malignant tumours and photodynamic therapy.

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When phosphate and tyroxine (activators of brain glutaminase) are used in small amounts, a potentiation of their stimulatory effect is observed. Higher concentrations exhibit an opposite effect. Glutamic acid has a strong inhibitory effect on all the activators of glutaminase given separately.

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It has been shown that the glutaminase activity of brain mitochondrial fractions, which is stimulated by various activators, is completely abolished on 10 min preincubation with parachlormercurybenzoate, 5,5'-dithiobis-(2-nitrobenzoate), N-ethylmaleimide, iodoacetamid, CdCl2, ZnCl2 and CuCl2. With the purpose of elucidating the role of SH-groups in glutaminase activity we have studied the possibilities of preventing loss of enzyme activity by substrates and activators. We have shown that glutamine is effective only in the case of CuCl2.

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