[Comparative antioxidant and antihypoxic activities of new 1,4-dihydro-4-oxopyrimidine derivative--compound PDMpT.HCl and mexidol].

Compound PDMpT.HCI reduces intensity of lipoperoxidation, activates antioxidant system and increases animal life expectancy under hypoxic circumstance.

[Effect of flavicin on vasodilating and antithrombotic endothelial functions in animals with experimental diabetes mellitus].

It is established that flavonoid flavicin improves antithrombotic and vasodilating functions of blood vessels in rats with endothelial dysfunction caused by streptozotocin-induced diabetes.

[Development and estimation of nanosomal rifampicin].

A lab-scale method for preparation of rifampicin-loaded polybutylcyanoacrylate nanoparticles (nanosames) was developed. The biodistribution of the nanosome-entrapped rifampicin after its intravenous administration was studied on healthy mice. The nanoparticles provided significant liver and spleen accumulation of rifampicin.

[Enzymatic acetylation of xenobiotics: its efficacy and role in side effects].

Quantum-chemical calculations of a series of molecules with primary amino groups were carried out, and the results were compared with experimental data on the in vivo acetylation degree. A criterion of the interaction efficiency of primary amines with arylamine N-acetyltransferase was suggested. An analysis of the known data and the results of our calculations showed that the interaction peculiarities of xenobiotics containing primary amino groups with the acetylating system of an organism largely define the spectrum of side effects of these xenobiotics.

[Morphologic changes in the rat inferior olive after its neurotoxic destruction with different doses of 2-acetylpyridine].

Neurotoxic effect of 3 acetylpyridine administered in different doses to adult outbred albino rats caused morphological changes in neurons of inferior olive: nucleus translocation towards cell body periphery with central chromatolysis, cytoplasm homogenisation complete dissolution of chromatophilic substance, disappearance of cell contours with glia preservation. The most severe lesion of the nervous tissue was observed in basal olive and dorsal accessory olive in all cases studied. Majority of neurons remained unchanged in medial accessory olive and its subdivisions.

[Compensatory rehabilitation processes and instrumental reflexes in rats after neurotoxic lesions in the inferior olive].

Training and recovery of instrumental equilibrium reflexes are impossible after total neurotoxical destruction of the inferior olive in rats. Motor deficits and compensatory rehabilitation processes in rats following 3-acethylpyridine treatment and high transection of the dorso-lateral funiculus of the spinal cord are closely correlated with the degree of the inferior olive destruction. The data obtained revealed an improvement in the motor disturbance and a stabilising of the instrumental reflexes in the rats with subtotal lesion of the inferior olive.

[Electronic and spatial parameters of antiparallel and parallel double-stranded beta-structure of a protein and its associates].

Calculations of valerolactam and N-methylacetamide dimers by the method of molecular orbitals in CNDO/2H, MINDO/3, MINDO/3H, MNDO, MNDO/H, AM1, and PM3 approximations showed that the PM3 was the most suitable method for the description of geometrical and thermodynamic characteristics of hydrogen bonds between their amide groups. The calculation of the H-bound dimers of N-acetylalanine methylamide, which mimicked the beta structure of protein macromolecule, showed that the antiparallel conformation of the dimer is by 2.85 kcal/mol more stable than the parallel conformation.

[The search for new antiallergy compounds among a number of coumarin derivatives and the study of their mechanisms of action].

The antiallergic effects of new novel synthetic coumarine-3-carboxylic acid derivatives were studied in a rat model of passive cutaneous anaphylaxis. The most potent agent was found and tested for mechanisms of its specific pharmacological action. Its capacity of suppressing immediate hypersensitivity in various animal species was demonstrated to be due to its concomitant action on the pathochemical and pathophysiological stages of the allergic process.

[The comparative characteristics of the background neuronal activity of the central cerebellar nuclei in the alert cat].

Neuronal background activity of the cerebellar central nuclei was studied in alert cats. Statistical analysis revealed some differences in the activity due, probably, to the nuclei's cytoarchitectonic specifics and diversity of afferent cerebellar cortical inputs.

[Neuronal reactions of the central cerebellar nuclei in the waking cat to cortical and peripheral stimuli].

Neuronal responses of the central cerebellar nuclei to electrical stimulation of the cerebral cortex and electrocutaneous stimulation of the limbs were studied in alert cats. An obvious responsiveness of neurons of the fastigial nucleus to the peripheral signals and impulses from the motor cortex was found. The neurons of the n.

[Responses of neurons of the lateral cerebellar nucleus of the alert cat to somatosensory stimulation].

Temporal characteristics of responses of the lateral nucleus neurons to electrocutaneous stimulation of limbs was studied in alert cats. Spinal afferent input to lateral nucleus neurons was found to exist. Effects from the forelimbs, particularly ipsilateral ones, are predominant.

[Features of the afferent control of spike activity of neurons of the interstitial nucleus of the cerebellum in the awake cat].

Characteristics of neuronal responses of the cerebellar nucleus interpositus to electrical stimulation of limbs were studied in alert cats. Somatosensory inputs to neurons of the nucleus are transmitted, mainly, via short--latency afferents without involving the cerebellar cortex. Nembutal anesthesia sharply reduced the number of early excitatory reactions and increased the number of inhibitory responses.

[Morpho-functional analysis of the nature of cerebello-hippocampal connections].

Spontaneous and evoked electric activity of the cat dorsal hippocampus neurons revealed the stimulation of cerebellar fastigial and interpositus nuclei to have bilateral mostly facilitating influence on hippocampal neuron activity, with more obvious contralateral effects. Convergence of afferent signals from structures under study is also more often observed in contralateral hippocampal neurons. Effects of fastigial nucleus stimulation are predominant.

[Analysis of focal potentials in the cat cerebral cortex during activation of cerebello-thalamo-cortical projection systems].

Peculiarities of topographical distribution of responses of the cat cerebral cortex to stimulation of cerebellar and thalamic (ventro-lateral and ventral anterior) nuclei as well as cerebello-thalamo-cortical projection system and comparison between the cerebellar and thalamic responses revealed differences in focal potentials evoked in pericruciate and parietal cortex. The latencies of the potentials, similarity in shape and in depth of reversion suggest that the cerebello-cortical responses in the pericruciate cortex are mediated through the thalamic ventro-lateral nucleus making synapses in III-IV cortical layers while responses in the parietal cortex--through the thalamic ventral anterior nucleus making synapses in more superficial layers.