Int J Tuberc Lung Dis
December 2023
We report the results of a phase IIB study investigating the safety and effectiveness of atorvastatin use with standard anti-TB drugs. In this multicentre, open-labelled study, we recruited treatment-naÏve patients with uncomplicated pulmonary TB aged at least 18 years. Participants were randomly assigned to standard-of-care or standard-of-care plus oral dose of atorvastatin (40 mg) daily for 2 months.
View Article and Find Full Text PDFIntroduction: Chronic obstructive pulmonary disease (COPD) is a chronic respiratory disorder that affects millions of people worldwide and inhalation therapy is central to the symptomatic management of the disease. Therefore, knowledge of the minimum Peak inspiratory flow (PIF) requirements for specific inhalers especially dry powder inhalers (DPI's) is necessary when prescribing inhalation therapy. The purpose of this study is to assess the effect of COPD severity on PIF in patients with COPD.
View Article and Find Full Text PDFBackground: Inhalational therapy is the cornerstone in the management of chronic obstructive pulmonary disease (COPD) patients. Patients' peak inspiratory flow impacts effective dry powder inhaler (DPI) delivery and management outcome.
Objective: This study assessed peak inspiratory flow rates (PIFR) and determined the factors associated with suboptimal inspiratory flow rates among COPD patients.
Background And Objectives: Asthma is one of the common chronic diseases globally. There is paucity of data on perceived stress among patients with asthma in Nigeria. This study aimed to determine the extent of perceived stress and its association with coping strategies among adults with asthma.
View Article and Find Full Text PDFBackground: Coronavirus Disease 2019 (COVID-19) is anemerging disease with a global spread that has affected millions of lives. In Nigeria, the third wave of the outbreak is being experienced with many patients requiring hospitalization. Being a novel disease, we characterized the clinical profile and outcomes of patients admitted into our isolation centre.
View Article and Find Full Text PDFPan Afr Med J
August 2021
Introduction: the relationship between asthma control and health-related quality of life (HRQoL) in adult asthmatics is fairly established, but the unique contribution of atopy to this relationship has received less attention. The aim of this study was to quantify the contribution of atopy to this relationship.
Methods: in a cross-sectional study, we assessed HRQoL using mini-Asthma Quality of Life Questionnaire (AQLQ).
Background: Poor sleep quality is reportedly common among asthmatic patients, however, there is little or no data among Nigerian asthmatics. The purpose of this study was to determine the contribution of sleep quality to Asthma control OBJECTIVE-To determine the impact of sleep quality on asthma control amongst asthma patients at Federal Medical Centre, Owo, Ondo State. METHODS-This was a cross sectional study evaluating 100 clinically stable asthmatic patients at the outpatient department at Federal Medical Center, Owo.
View Article and Find Full Text PDFBackground: Assessment of control is central to asthma management. The Asthma Control Test (ACT) and Global Initiative for Asthma (GINA) defined control are commonly used measures of asthma control. This study examined the agreement between the ACT and GINA defined control and determined the best cut-off point of ACT to predict GINA level of control.
View Article and Find Full Text PDFBackground: Impaired sleep is reportedly common in chronic obstructive pulmonary disease (COPD) and the impact of quality of sleep on health-related quality of life (HRQL) has been documented. Although factors affecting HRQL have been investigated in various studies, the impact of sleep quality on HRQL has not been previously investigated among patients with COPD in Nigeria. The purpose of this study was to determine the contribution of sleep quality as a factor affecting HRQL.
View Article and Find Full Text PDFBackground And Objectives: We examined the association of respiratory symptoms, health status, and lung function with the use of solid fuel (wood, charcoal, coal or crop residue) for cooking or heating in a predominantly non-smoking population.
Methods: Using the protocol of the Burden of Obstructive Lung Diseases (BOLD) initiative, we collected representative population data using questionnaires and spirometry tests. We categorized solid fuel use into 'never user', 'ex user' and 'current user' based on responses to the survey.
Background: Chronic obstructive pulmonary disease (COPD) affects respiratory functioning and psychosocial factors. However, little is known about perceived ability of people with COPD to engage in a regular exercise program. This study assessed respiratory parameters, exercise capacity, psychosocial factors and their relations in people with COPD.
View Article and Find Full Text PDFThis study investigated the prevalence and association between exercise-induced asthma (EIA) and parental socio-economic status (PSES) among school-aged adolescents in a semiurban community in Nigeria. Three hundred and eighty-five adolescents (185 male and 200 female adolescents) whose ages ranged between 10 and 19 years participated in this cross-sectional study. Participants were recruited from four government approved secondary schools in Ido-Ekiti using a multistage sampling technique.
View Article and Find Full Text PDFRationale: Black Africans have reduced FVC compared with white persons, but the prevalence and determinants of reduced values are not well understood.
Objectives: To evaluate the prevalence and factors leading to reduced FVC in a Nigerian population and to examine current theories regarding the determinants of this difference.
Methods: We studied the ventilatory function of 883 adults aged 40 years or older participating in the Burden of Obstructive Lung Disease Study in Ile-Ife, Nigeria.
Background: Asthma continues to be an important cause of morbidity and mortality in developing countries. But, its burden among adult populations in university campuses is not well described.
Method: Through a multistage cluster sampling of students and staff of the Obafemi Awolowo University, Ile-Ife, Nigeria, we obtained a representative sample, each for students and staff.
Background: Asthma remains an important cause of morbidity and mortality, especially in developing countries but the prevalence in Nigeria is not well described.
Methods: Using the European Community Respiratory Health Survey (ECRHS) standard screening questionnaire and asthma criteria, we recruited a representative sample of adults resident in a suburban community in Nigeria through a stratified three-stage cluster sampling technique.
Results: Out of a total of 3590 individuals contacted, 2310 responded and provided completed data (62.
Background: Chronic Obstructive Pulmonary Disease (COPD) is a multi-systemic and progressive disease. However the determinants of its impact on health related quality of life are not well-studied or understood in Nigeria.
Objectives: To assess the determinants of health related quality of life in COPD.
Background: Tobacco use is one of the leading preventable causes of morbidity and mortality globally; about 70% of smokers see physicians each year. Health care professionals have a very unique role in motivating people to quit smoking.
Aim: The aims of this study were to document the smoking prevalence and attitudes regarding its control among these set of students who will be tomorrow's health care providers.
Introduction: Asthma continues to cause increasing morbidity and mortality among young adults in the developing world. There is scarcity of data on the prevalence of asthma among young Nigerian adults.
Methods: We studied the prevalence of asthma among students (15-35 years of age) of the Obafemi Awolowo University using a standardized questionnaire.