Prognostic Value of Histopathological Thrombus Age in Large Vessel Occlusion-Related Stroke.

Introduction: Acute mechanical thrombectomy (MT) is the preferred treatment for large vessel occlusion-related stroke. Histopathological research on the obtained occlusive embolic thrombus may provide information regarding the aetiology and pathology of the lesion to predict prognosis and propose possible future acute ischaemic stroke therapy.

Methods: A total of 75 consecutive patients who presented to the Amphia Hospital with acute large vessel occlusion-related stroke and underwent MT were included in the study.

No evidence for cerebellar abnormality in adults with developmental dyslexia.

Developmental dyslexia is commonly believed to result from a deficiency in the recognition and processing of speech sounds. According to the cerebellar deficit hypothesis, this phonological deficit is caused by deficient cerebellar function. In the current study, 26 adults with developmental dyslexia and 25 non-dyslexic participants underwent testing of reading-related skills, cerebellar functions, and MRI scanning of the brain.

Etiology of language network changes during recovery of aphasia after stroke.

Knowledge of spatiotemporal patterns of language network changes may help in predicting outcome in aphasic stroke patients. Here we assessed language function and performed functional MRI four times during one year to measure language network activation and cerebrovascular reactivity (with breath-holding) in twelve left-hemispheric stroke patients, of whom two dropped out before the final measurement, and eight age-matched controls. Language outcome was related to increase of activation in left and right posterior inferior temporal gyrus over the first year, while activation increase in right inferior frontal gyrus was inversely correlated to language recovery.

Pore REconstruction and Segmentation (PORES) method for improved porosity quantification of nanoporous materials.

Electron tomography is currently a versatile tool to investigate the connection between the structure and properties of nanomaterials. However, a quantitative interpretation of electron tomography results is still far from straightforward. Especially accurate quantification of pore-space is hampered by artifacts introduced in all steps of the processing chain, i.

Demonstrating the benefits and pitfalls of various acidity characterization techniques by a case study on bimodal aluminosilicates.

A new combination of a volumetric with a dynamic method to investigate the acidity properties of aluminosilicates is introduced. In the first step, the total acidity is determined volumetrically by the measurement of two-cycle adsorption (TCA) isotherms with ammonia as a probe, directly followed by a dynamic temperature-programmed desorption (TPD) experiment to define the acid strength distribution. Furthermore, the results obtained by the new direct combination of TCA and TPD are validated by comparison with an in-situ FTIR (Fourier transform infrared) study with the same probe molecule on the same materials.

Increase in sensorimotor cortex response to somatosensory stimulation over subacute poststroke period correlates with motor recovery in hemiparetic patients.

Background: . Somatosensory input to the motor cortex may play a critical role in motor relearning after hemiparetic stroke.

Objective: .

Influence of surfactant concentration on the surface morphology of hollow silica microspheres and its explanation.

The surface morphology of hollow silica microspheres has influence on their applications. After a thorough investigation of the deposition of silica nanoparticles on polystyrene (PS) beads and the surface morphology and texture of the resultant hollow silica shells with scanning electron microscopy, transmission electron microscopy, and N2-sorption measurements, the influence of surfactant [cetyltrimethylammonium bromide (CTAB)] concentration on the surface morphology of hollow silica microspheres templated by PS beads is explained. Previously, CTAB was believed to turn the surface charge of PS beads from negative into positive so that negatively charged silica could be deposited on the PS template.

Contribution of the left and right inferior frontal gyrus in recovery from aphasia. A functional MRI study in stroke patients with preserved hemodynamic responsiveness.

The relative contribution of dominant and non-dominant language networks to recovery from aphasia is a matter of debate. We assessed with functional magnetic resonance imaging (fMRI) to what extent the left and right hemispheres are associated with recovery from aphasia after stroke. fMRI with three language tasks was performed in 13 aphasic stroke patients and in 13 healthy subjects.

Cerebrovascular reserve capacity is preserved in a population-based sample of patients with type 2 diabetes mellitus.

Background And Purpose: Type 2 diabetes mellitus (DM2) is associated with an increased risk of stroke. DM2 is also associated with cognitive impairments. Vascular dysfunction, such as impaired cerebrovascular reserve capacity (CVR), may be a determinant of these changes, but previous studies on CVR in DM2 have provided variable results in selected populations of patients.

Coronary heart disease risk indicators, aerobic power, and physical activity in men with spinal cord injuries.

Objective: To compare the lipid and (apo-)lipoprotein profile and blood pressure of men with long-standing spinal cord injuries (SCI) to those of an age-matched able-bodied (AB) population, and to assess the most important determinants of this profile and blood pressure.

Design: A cross-sectional study of persons with chronic SCI residing in the community.

Setting: Tests were performed in a university research laboratory.

Changes in physical strain and physical capacity in men with spinal cord injuries.

To determine longitudinal changes in physical capacity and physical strain during activities of daily living (ADL), 37 men with spinal cord injuries (C4/5-L5) performed an exercise test and various ADL on two occasions (T1 and T2; interval 34.5 +/- 1.5 months).

Relationship between physical strain during standardised ADL tasks and physical capacity in men with spinal cord injuries.

To describe physical strain during activities of daily living (ADL), 44 men with spinal cord injuries (C4-L5) performed a set of standardised tasks. The physical strain was defined as the highest heart rate response expressed as a percentage of the individual heart rate reserve (%HRR). The physical strain averaged over the subjects who performed all tasks (n = 24) was (mean +/- SD): 20.

Physical strain in daily life of wheelchair users with spinal cord injuries.

Forty-three men (age 33 +/- 9 yr) with spinal cord injuries (SCI) were observed during a normal workday while heart rate was recorded continuously. Physical strain was estimated using the heart rate response expressed relative to the individual heart rate reserve (%HRR). The mean physical strain during the day for group I (C4-C8, N = 9), II (T1-T5, N = 6), III (T6-T10, N = 15), and IV (T10-L5, N = 13) was 38 +/- 8, 29 +/- 12, 22 +/- 8, and 23 +/- 5%HRR, respectively.

Reliability of heart rate responses to non-steady-state activities of daily living in men with spinal cord injuries.

The reliability of heart rate responses to non-steady-state tasks among 37 men with spinal cord injuries (lesion level: C4/5-L5) was examined with a simple heart rate recording device (Sport Tester PE3000). Three identical trials of 6 different transfers and an 8-cm curb ascent were performed on one day (Trial 1 and 2; n = 37) and one week later (Trial 3; n = 12). Pearson's r and intraclass correlations for the highest and the mean heart rate provoked during Trial 1 and 2 ranged from 0.

The exon 4 poly(A) site of the human calcitonin/CGRP-I pre-mRNA is a weak site in vitro.

The human calcitonin/CGRP-I (CALC-I) pre-mRNA is processed in a tissue-specific alternative way into either calcitonin (CT) or calcitonin gene-related peptide-I (CGRP-I) mRNA. The exons 1 to 3 are common exons. They are spliced to exon 4, which becomes polyadenylated to form CT mRNA, or to exon 5 and the polyadenylated exon 6 to form CGRP-I mRNA.

Two different sequence elements within exon 4 are necessary for calcitonin-specific splicing of the human calcitonin/calcitonin gene-related peptide I pre-mRNA.

The calcitonin (CT)/calcitonin gene-related peptide I (CGRP-I) gene (CALC-I gene) is subject to alternative tissue-specific processing of its primary transcript. CT mRNA is the predominant mRNA produced in thyroid C cells, whereas CT gene-related peptide I mRNA is the main product in neurons of the central and peripheral nervous systems. The CT-specific exon 4 is surrounded by weak processing sites.

Isometric strength, sprint power, and aerobic power in individuals with a spinal cord injury.

This study investigated in rather specific wheelchair tests the relationships among estimates of isometric upper-body strength (Fiso), sprint power (P30), aerobic power (VO2peak), and maximal power output (POaer) in a group of 44 men (age 34 +/- 12 yr) with longstanding spinal cord injuries ranging from C4/C5 to L5. Fiso was defined as the maximum force that could be exerted on the blocked rims of a stationary wheelchair ergometer. The estimation of P30 involved the measurement of the mean power during a 30-s all-out sprint test on the same wheelchair ergometer.

Responses of subjects with spinal cord injuries to maximal wheelchair exercise: comparison of discontinuous and continuous protocols.

Six male subjects with spinal cord injuries (SCI) participated in this investigation to compare peak values of oxygen uptake (VO2), heart rate (fc), ventilation (VE), respiratory exchange ratio (R) and power output (W) obtained using a discontinuous (DP) and a continuous jump max protocol (JMP) in a maximal wheelchair exercise test on a treadmill. The W increments were achieved by imposing an extra mass upon the wheelchair through a pulley system. The DP involved exercise periods of 3 min separated by 2-min intervals at relative rest.

Identification of distinct cytoplasmic targets for ras/R-ras and rho regulatory proteins.

The protein products of the mammalian ras genes, p21ras, are regulatory guanine nucleotide binding proteins that are involved in the control of cell proliferation, though the exact biochemical processes regulated are unknown. Recently a cytoplasmic protein has been identified that interacts with and increases the GTPase activity of p21ras. It has been shown that this GTPase-activating protein, or GAP, interacts with the effector domain of ras, leading us and others to propose that GAP may be the target for regulation by p21ras.