Synthesis, pharmacokinetics, efficacy, and rat retinal toxicity of a novel mitomycin C-triamcinolone acetonide conjugate.

A novel conjugate of mitomycin C (MMC) and triamcinolone acetonide (TA) was synthesized using glutaric acid as a linker molecule. To determine the rate of hydrolysis, the conjugate was dissolved in aqueous solution and the rate of appearance of free MMC and TA was determined by high-performance liquid chromatography analysis. Antiproliferative activity of the MMC-TA conjugate and parent compounds was assessed using an NIH 3T3 fibroblast cell line.

Generation of hybrid elloramycin analogs by combinatorial biosynthesis using genes from anthracycline-type and macrolide biosynthetic pathways.

Elloramycin and oleandomycin are two polyketide compounds produced by Streptomyces olivaceus Tü2353 and Streptomyces antibioticus ATCC11891, respectively. Elloramycin is an anthracycline-like antitumor drug and oleandomycin a macrolide antibiotic. Expression in S.

[Avoidance learning in a social situation- extinction resistance and defense reaction under stress. A pilot study].

Two successive experiments were conducted resulting from observations of the stability (resistance to extinction) of avoidance reactions and the manifestation of such reactions beyond the specific avoidance conditions in which they were acquired: a) 15 subjects were set the task to avoid an aversive acoustic stimulus for a helpless experimental partner. They could achieve this by reacting with contraction of either the forearm or the calf muscles in a difficult discrimination task. The stability of these avoidance reactions was assessed on different levels of forced extinction.