Publications by authors named "Odyssee Merveille"

Segmentation in medical imaging is an essential and often preliminary task in the image processing chain, driving numerous efforts towards the design of robust segmentation algorithms. Supervised learning methods achieve excellent performances when fed with a sufficient amount of labeled data. However, such labels are typically highly time-consuming, error-prone and expensive to produce.

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Cerebrovascular segmentation is a crucial preliminary task for many computer-aided diagnosis tools dealing with cerebrovascular pathologies. Over the last years, deep learning based methods have been widely applied to this task. However, classic deep learning approaches struggle to capture the complex geometry and specific topology of cerebrovascular networks, which is of the utmost importance in many applications.

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Vessel enhancement (aka vesselness) filters, are part of angiographic image processing for more than twenty years. Their popularity comes from their ability to enhance tubular structures while filtering out other structures, especially as a preliminary step of vessel segmentation. Choosing the right vesselness filter among the many available can be difficult, and their parametrization requires an accurate understanding of their underlying concepts and a genuine expertise.

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Objective: This article presents an automatic image processing framework to extract quantitative high-level information describing the micro-environment of glomeruli in consecutive whole slide images (WSIs) processed with different staining modalities of patients with chronic kidney rejection after kidney transplantation.

Methods: This four-step framework consists of: 1) approximate rigid registration, 2) cell and anatomical structure segmentation 3) fusion of information from different stainings using a newly developed registration algorithm 4) feature extraction.

Results: Each step of the framework is validated independently both quantitatively and qualitatively by pathologists.

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Curvilinear structure restoration in image processing procedures is a difficult task, which can be compounded when these structures are thin, i.e., when their smallest dimension is close to the resolution of the sensor.

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The analysis of thin curvilinear objects in 3D images is a complex and challenging task. In this article, we introduce a new, non-linear operator, called RORPO (Ranking the Orientation Responses of Path Operators). Inspired by the multidirectional paradigm currently used in linear filtering for thin structure analysis, RORPO is built upon the notion of path operator from mathematical morphology.

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