RNA transcription and lysosomal activation during xenotransplant hyperacute rejection: inhibition of RNA polymerase.

In summary, our data indicates that AFB1 has no effect on LyAct during XTHAR. Although these results are from short-term incubation studies, they nevertheless suggest that inhibition of RNA transcription by AFB1 may be of no consequence in LyAct during XTHAR. Hence, our results appear to support the view that, in general, XTHAR recruits preformed components and may not require de novo synthesis of lysosomal proteins.

Ethnic variations in lung cancer.

Cancer of the lung is the most frequent cancer in the world, but with wide geographical variation in risk. It is most spread among males of all races worldwide, the only exception being its incidence among Chinese women aged 70 years and older. When comparing the different ethnic groups we have to consider that besides inhaling cigarette smoke actively or as a passive smoker the exposure to occupational carcinogens varies considerably according to different work places.

Racial variation in lung cancer.

Lung cancer claimed about 153,000 lives in 1994 in the United States. Despite research overall lung cancer survival has still not improved during the last 20 years, with 5-year relative survival remaining about 13%. In addition several epidemiologic and molecular studies showed a difference in the incidence of lung cancer in the three major races.

Splenectomy in cancer surgery: diminishing indications?

The diminishing enthusiasm towards performing splenectomy (SPL) either as an integral part of surgical cancer management (SCM), or for staging/management (ST) of lymphoma, warranted our assessment of the extent of this trend in a minority population. We retrospectively analysed all SPL submitted to Surgical Pathology for histological processing over a 24-year period (1/1/70-12/31/93) at the Howard University Hospital, a predominantly African-American institution. Of the 446 SPL performed during the period, sixty-nine (15.

Post-transplant malignancies in minority populations.

Post-transplant malignancy (PTM), is emerging as an important cause of early morbidity and mortality following transplantation (TX). Unfortunately its prevalence in minorities (African-Americans, AA; Native Americans, NA; Asian Pacific Islanders, AP; American Indians, AI; Latino-Hispanics, LH) in the United States, though important, remains unknown. Published reports of prevalence rates by different centers, including the Cincinnati Transplant Tumor Registry (CITTR) of about 4%-18% though informative, remain of little help.

Gastric carcinoma in African Americans: a 10 year single center analysis.

The occurrence of gastric cancer (GCa) has been declining in the U.S. over the past years.

Spontaneous rupture of the renal allograft.

Spontaneous renal allograft rupture, an unusual complication of renal transplantation, occurred in a 35-year-old woman 10 days after transplantation. Unusual localized pain and tenderness at allograft site, oliguria, and hypotension, a triad frequently seen in renal allograft rupture, were present. Management by transplant nephrectomy was inevitable because of the patient's downhill course.

Tracheopleuropulmonary injuries following enteral tube insertion.

Eighty-three cases of tracheopleuropulmonary injuries complicating enteral tube feeding are analyzed to identify the patterns of injury, and precipitating factors and ways to avoid them. Six new cases observed by the authors and 77 other cases cited in British literature between 1976 and 1987 are presented. In recent years, reports of this complication have been increasing, apparently in a geometrical progression: 8%, 18%, and 74% were reported between 1976 to 1979, 1980 to 1983, and 1984 to 1987, respectively.