Publications by authors named "Odobi R Ushang"
Article Synopsis
- The study explored how quercetin protects against immune suppression caused by cyclophosphamide (CYP) in male Wister rats, focusing on oxidative and inflammatory stress impacts.
- Quercetin, when administered alongside CYP, helped reduce oxidative stress and inflammation in brain regions by boosting antioxidant enzyme activity and lowering harmful markers like interleukin-6 and interferon-γ.
- Behavioral tests showed that quercetin significantly improved depressive-like behaviors in rats treated with CYP, suggesting its potential as a protective agent against stress-induced mental health issues.
The present study investigated the attenuating effects of Zn following Cd-exposure in the activities/expression of indoleamine 2, 3-dioxygenase (IDO), tryptophan 2, 3-dioxygenase (TDO), oxidative-inflammatory response, behavioral indices and histologic architecture in cerebral cortex and hippocampus of male rats. Adult male Wistar rats were exposed to 200 μg/L and 100 μg/L of Cd and/or Zn in drinking water for 42 days. Cd exposure significantly increased IDO and TDO activities, IDO 1 protein expression, inflammatory response, with attendant disruption in antioxidant systems and concomitant elevation in malondialdehyde (MDA) levels in the cerebral cortex and hippocampus.
View Article and Find Full Text PDF