Publications by authors named "Odintsova I"

Article Synopsis
  • Locus coeruleus (LC) neurons, responsible for norepinephrine release in the hippocampus, are primarily activated by novel stimuli and changes in the environment, leading to a hypothesis that their activation resets neural networks.
  • Research involving male rats demonstrated that phasic (burst) activation of the LC prior to placing them in familiar or novel environments can reset hippocampal maps, while silencing the LC prevents this reset and maintains familiar maps in certain hippocampal regions.
  • The findings emphasize that phasic LC activity is crucial for encoding new experiences and updating memory, while tonic activation alone does not activate changes in network representations, indicating the importance of activation patterns for neural function.
View Article and Find Full Text PDF

There was studied population-based survival of 1689 breast cancer patients in the Republic of Buryatia whose had been di- agnosed in 2007-2013 on the basis of cancer registry database. There was performed an estimation and analysis of observed adjusted and relative survival. The higher stage of the disease and older age of women at the diagnosis the lower rates of 1- and 5-year survival.

View Article and Find Full Text PDF

Breast cancer is the most common cause of cancer death in the Republic of Buryatia as a whole and among urban population (13.3 % and 16.0 %, respectively), and the second place belongs to rural population (11.

View Article and Find Full Text PDF

The epidemiological study in Vladivostok and Primorye Territory in period 1999 to 2013 was performed. In the structure of cancer incidence at the evaluated areas, renal cancer occupies fifth place among male population (5.7 and 5.

View Article and Find Full Text PDF

The effectiveness of molecular markers for the identification of leaf rust resistance genes Lr28, Lr35, Lr47 transferred to common wheat was assessed the using samplesof Triticum spp. and Aegilops spp. from Ae.

View Article and Find Full Text PDF

From all regions of the Siberian Federal District (SFD), the Altai Republic is the least urbanized territory, more than third of its population is Altai. The Altai Republic ranks the 11th for cancer incidence among 12 territories of SFD. Cancer incidence rate is 1.

View Article and Find Full Text PDF

Cancer mortality rate in the Altai Republic is the lowest among the territories of the Siberian Federal District. Cancer mortality rate in females is 1.9 times lower than that in males.

View Article and Find Full Text PDF

The objective of the present work was to study the prevalence of malignant oral cavity and pharynx neoplasms among the population of the region of Siberia and Far East. These neoplasms are the ninth most frequent conditions in the structure of malignant tumours among the male population and rank the eighteenth among the women. On the whole, the morbidity rate of oral cavity and pharyngeal cancer (3.

View Article and Find Full Text PDF

Classic models of the hippocampus uniformly ascribe pattern completion to CA3, but recent data suggest CA3c (enclosed by the dentate gyrus) may act in a manner more consistent with the dentate and aid in pattern separation. The ideal test for functional distinction within CA3, however, is to compare the responses in these regions in the same animal in multiple contexts. To accomplish this, animals visited two contexts with varying degrees of similarity and the pattern of repeated Arc expression was examined across the pyramidal cell layer.

View Article and Find Full Text PDF

The demographic situation impacts the level of morbidity indirectly. The evaluation of demographic situation if the Republic of Altai was made. In 2010, in the ethnic structure of population the percentage of Russians reduced up to 55.

View Article and Find Full Text PDF

Background: Ethnic diversity of the population in the region of Siberia suggests the existence of different germline mutations in the BRCA1/2 genes associated with breast and ovarian cancer in different ethnic populations, but spectrum of these mutations has not been studied.

Objective: Our aim was to evaluate the frequency of the most common mutations BRCA1/2 (BRCA1 5382insC, BRCA1 185delAG, BRCA1 4153delAG, BRCAI T300G, BRCA2 6174delT) in women diagnosed with breast cancer among indigenous people and newcomers living in Siberia.

Methods: We tested 1281 genomic DNA samples for the presence of BRCA1 5382insC mutation in patients diagnosed with breast cancer considering no family history.

View Article and Find Full Text PDF

Response reversal learning is facilitated in many species, including humans, when competing responses occur in separate contexts. This suggests hippocampal maps may facilitate the acquisition of competing responses and is consistent with the hypothesis that contextual encoding permits rapid acquisition of new behaviors in similar environments. To test this hypothesis, the pattern of Arc expression was examined after rats completed a series of left/right response reversals in a T-maze.

View Article and Find Full Text PDF

The article presents the results of an epidemiological study of territorial and temporal characteristics of incidence of renal cell carcinoma in population of Siberia and the Far East, taking into account age and gender. In the average, regional incidence of renal cell carcinoma in men was 10.6 +/- 0.

View Article and Find Full Text PDF

In 2004-2008 the Khabarovsk Region was considered as a territory of an increased risk for prostate cancer with the incidence rate of 22.2 +/- 1.6 per 100000 males.

View Article and Find Full Text PDF
Article Synopsis
  • Antidepressants like fluoxetine boost mood and increase new neuron production in the dentate gyrus (DG), which is linked to learning and memory.
  • *Despite this, studies show mixed results on how antidepressants affect memory, suggesting a need to explore the behavior of the new neurons.
  • *This research indicates that the new neurons generated after fluoxetine treatment are functional but tend to accumulate in brain regions not engaged during spatial memory tasks, potentially explaining the mixed memory results.
View Article and Find Full Text PDF

The objective of this study was to characterize morphologically the spinal cord neurons in Highsex-White Cross E-21 chick embryos at developmental days 10, 12, 15, 17 and 19. The total of 125 chick embryos were used. The study of the isolated neurons demonstrated the consistent changes of nucleocytoplasmic ratio and nuclear DNA content.

View Article and Find Full Text PDF

The review discusses whether it is worth identifying concepts, such as the endogenous intoxication syndrome and systemic inflammatory response syndrome (SIRS). It also analyzes various aspects of the historically established approaches to diagnosing and treating these syndromes and provides evidence for the staging of SIRS and the possibility of using this approach in clinical practice. This will allow treatment policy to be modified.

View Article and Find Full Text PDF

The Tomsk Region belongs to the areas of Siberia and the Far East which show a higher risk for hemoblastoses in the population. Chronic leukemia are prevalent in the structure of oncohematologic morbidity in the Tomsk Region as compared with other areas of Siberia and the Far East. There is a relationship of technogenic environmental pollution to the incidence of some nosological entities of hemoblastoses in the Region.

View Article and Find Full Text PDF

Different hypotheses concerning durable plant resistance against different pest were tested: 1) resistance is weak and polygenetically controlled; 2) resistance depends on "residual effect" of oligogenes that were overcome by pests. Contrast pair of plants and pests were used in experiments: wheat, barley--facultative parasite Bipolaris sorokiniana Shoem., wheat--obligate parasite Puccinia recondita Rob.

View Article and Find Full Text PDF