Efficacy and safety of long-term therapy with nucleos(t)ide analogues in chronic hepatitis B.

Aim: To assess the efficacy and safety of long-term treatment with nucleos(t)ide analogues in patients with chronic hepatitis B.

Materials And Methods: We conducted an observational study in 101 chronic hepatitis B (HBeAg-negative and HBeAg-positive) patients treated (≥3 years) with entecavir, tenofovir or telbivudine.

Results: Treatment with entecavir and tenofovir was associated with high rate of virologic and biochemical response (>95%) and HBeAg seroconversion (93% and 67%, respectively).

[Current concepts of pathogenesis, clinical course and treatment of hepatitis delta (35 years since its discovery)].

Chronic HDV infection is a most serious and rapidly progressing hepatic disease with high risk of liver cirrhosis and hepato cellular carcinoma (HCC). Many aspects of its pathogenesis, virus biology and treatment remain unknown 35 years after the discovery of the disease. HDV is significantly different from HCV and HBV despite common route of infection.

[Congenital bile duct hypoplasia (Alagille-Watson syndrome)--a rare cause of biliary cirrhosis in adults].

A case of a rare hereditary disease, Alagille-Watson syndrome, is reported. It most frequently affects liver and cardiovascular system which leads to biliary cirrhosis and cardiovascular catastrophe in young patients. Pathogenesis and clinical variants of the disease are described.

[Estimation of rate constant for dissolution of radioactive fuel particles].

Some theoretical of the experimental investigation of solubility of radioactive aerosols were examined. Filters, which were exposed during October-November 1987 in Pripyat town, were studied. Measurements on 22 November 1987 showed that an activity in the air was 12.

Schottky barriers in carbon nanotube heterojunctions.

Electronic properties of heterojunctions between metallic and semiconducting single-wall carbon nanotubes are investigated. Ineffective screening of the long-range Coulomb interaction in one-dimensional nanotube systems drastically modifies the charge transfer phenomena compared to conventional semiconductor heterostructures. The length of depletion region varies over a wide range sensitively depending on the doping strength.

[The interpretation of the data from the ultrasonic examination of patients with acute and chronic suppurative lung and pleural diseases].

Observations were made in 104 patients with acute and chronic lung abscesses and pleural empyema. The endoscopic, bacteriological and ultrasonic methods were used to make full diagnosis and to begin treatment. This article describes the part of the work devoted to the ultrasonic diagnostics.

[Clinical and radiographic characteristics of tuberculosis in infants].

Epidemiological and BCG vaccination background and clinicoroentgenological signs of tuberculosis were analysed with reference to epidemiological and BCG vaccination background in 177 infants. In infants tuberculosis was represented primarily by intrathoracic lymph node tuberculosis running as infiltrative, tumorous and minor. Disseminated tuberculosis and meningitis occurred as a rule within the first year of life.

[Clinical course of tuberculosis in young children, vaccinated and non-vaccinated with BCG vaccine].

As shown by the analysis of tuberculosis forms in 27 infants under 1 year of age (group 1) and 150 infants of older age (group 2), the involvement of the intrathoracic lymph nodes holds the first place among tuberculosis forms encountered in infants. Severe infection (tuberculous meningitis, disseminated tuberculosis) occurred more frequently in group 1. The authors emphasize epidemiological significance of contacts with tuberculous patients.

[Serological diagnosis of tuberculosis in children by using erythrocyte preparations].

The results of indirect hemagglutination with phosphatide and protein antigens in children with different manifestations of primary Tb infection point to a high diagnostic potential of the serological method. Specially designed and tested diagnostic preparations made of TB and BCG vaccine strain tuberculin can perfect the diagnosis of tuberculosis and determination of its activity. Employment of the erythrocytic diagnosticum with BCG tuberculin extends the potential of detecting postvaccinal complications in children immunized with BCG vaccine.