Publications by authors named "Odin M Schaepkens"
Together with obesity and type 2 diabetes, metabolic dysfunction-associated steatotic liver disease (MASLD) is a growing global epidemic. Activation of the complement system and infiltration of macrophages has been linked to progression of metabolic liver disease. The role of complement receptors in macrophage activation and recruitment in MASLD remains poorly understood.
View Article and Find Full Text PDFArticle Synopsis
- Metabolic dysfunction-associated steatotic liver disease (MASLD) is increasingly common alongside obesity and type 2 diabetes, with a link to immune responses involving complement proteins and macrophages.
- The study investigates the role of the complement 3a receptor (C3aR1) in macrophages, particularly in the liver's Kupffer cells, by creating mouse models lacking this receptor.
- Results show that deleting C3aR1 in macrophages or Kupffer cells doesn't significantly impact liver conditions like steatosis, inflammation, or fibrosis in the context of a MASLD-inducing diet.