Publications by authors named "Odelia Orbaum-Harel"
Comparative Review of the Conserved UL24 Protein Family in Herpesviruses.
Int J Mol Sci
October 2024
The UL24 protein family, conserved across all subfamilies of Orthoherpesviridae, plays diverse and significant roles in viral replication, host-virus interactions and pathogenesis. Understanding the molecular mechanisms and interactions of UL24 proteins is key to unraveling the complex interplay between herpesviruses and their hosts. This review provides a comparative and comprehensive overview of current knowledge on UL24 family members, including their conservation, expression patterns, cellular localization, and functional roles upon their expression and during viral infection, highlighting their significance in herpesvirus biology and their potential functions.
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- - KSHV is a cancer-causing virus linked to Kaposi's sarcoma and other rare blood cancers, and this study investigates the role of a specific protein, ORF20, in its lifecycle.
- - Researchers created a virus that lacks the ORF20 gene (ORF20-Null KSHV) and found that this mutant virus resulted in faster viral gene expression but ultimately led to cell death and decreased viral production upon reactivation.
- - The study highlights that reinstating the short form of ORF20 could restore viral production and reduce cell death, suggesting ORF20's role in enhancing viral reactivation and potential infectious particle production through its endonuclease function.