Early Technology Readiness Level (TRL) Development of the Microfluidic Inorganic Conductivity Detector for Europa and the Solenoid-Based Actuator Assembly for Impact Penetrators.

This study introduces an innovative in situ lander/impact-penetrator design tailored for Discovery-class missions to Europa, specifically focused on conducting astrobiological analyses. The platform integrates a microfluidic capacitively coupled contactless conductivity detector (C4D), optimized for the detection of low-concentration salts potentially indicative of biological activity. Our microfluidic system allows for automated sample routing and precise conductivity-based detection, making it suitable for the harsh environmental and logistical demands of Europa's icy surface.

Medical students' knowledge, attitude, and practice regarding hepatitis B and C virus infections in Jordan: A cross-sectional study.

Background And Aims: We aimed to assess the levels of hepatitis B and C knowledge, attitudes, and practices among medical students in Jordan. A survey included participation from medical students across all faculties in Jordan, from 2022 to 2023.

Methods: The data were analyzed with The R Statistical Software (v4.

Exploring public perception and utilization of medication home delivery services in the United Arab Emirates: a cross-sectional study.

Introduction: The Medication Home Delivery (MHD) service from community pharmacies involves the safe and efficient delivery of pharmaceuticals (prescription and non-prescription medications), and health products directly to the patient's/consumer's home. There are several issues encountered by the users of the MHD service that have an impact on their satisfaction with the service. The study aimed to assess the public's perceptions of the MHD service in the United Arab Emirates (UAE), their willingness to utilize it, and the practical use of the service.

Test anxiety and coping strategies among university students an exploratory study in the UAE.

Test anxiety is a widespread problem among university students, with negative consequences for their social, physical, and academic well-being. Therefore, students may engage in activities that might alleviate anxiety symptoms, including taking medication. The study aimed to identify factors affecting test anxiety among medical and non-medical students during examination period and their coping approaches.

Endogenous histidine peptides are physiological antioxidants that prevent oligodendrocyte cell death and myelin loss in vivo.

Histidine dipeptides (HDs) are synthesized in brain oligodendrocytes by carnosine synthase (carns1), but their role is unknown. Using metabolomics and in vivo experiments with both constitutive and oligodendrocyte-selective carns1-KO mouse models, we found that HDs are critical for oligodendrocyte survival and protect against oxidative stress. Carns1-KO mouse models had lower numbers of mature oligodendrocytes, increased lipid peroxidation, and behavioral changes.

Towards digital readiness of evidence-based practice in a regional cancer center using role-based business process and data modeling.

Introduction: Evidence-based practice is a problem-based solving approach to clinical practice that encourages nurses providing personalized patient care while utilizing the necessary scientific evidence for a better understanding of risks and benefits of diagnostic tests and treatments. Digital transformation of an organization begins with attaining an acceptable digital readiness level. One approach entails specifying and modeling their processes and the respective data models.

Maternal-Fetal Transfer of Anti-SARS-CoV-2 Antibodies in Amniotic Fluid: Insights from Maternal Vaccination and COVID-19 Infection.

: As the COVID-19 pandemic wanes, understanding maternal-fetal antibody transfer remains crucial for optimizing vaccination strategies. This study evaluates anti-SARS-CoV-2 antibody levels in amniotic fluid following maternal BNT162b2 mRNA vaccination and/or COVID-19 infection during early pregnancy, focusing on the first and second trimesters. : A retrospective cohort study was conducted at a tertiary university-affiliated hospital, involving 149 pregnant women who underwent amniocentesis.

Using Adaptive Choice-Based Conjoint Approach to Facilitate Shared Decision-Making in Osteoarthritis Management: A Patient Perception Study.

Objective: This study examines the application of the adaptive choice-based conjoint (ACBC) method to facilitate the shared decision-making (SDM) process for osteoarthritis (OA) treatment.

Methods: The study recruited adult patients with OA attending the rheumatology/orthopedics clinics in a local urban hospital in Abu Dhabi, United Arab Emirates (UAE). Participants completed a questionnaire regarding who influences their decision in selecting OA medication, followed by an ACBC questionnaire about OA medication preferences and a questionnaire about the potential contribution of ACBC to the SDM process.

Pre-delivery BMI and the Accuracy of Fetal Weight Estimation in Very Preterm Infants.

Objectives: To examine the relation between maternal pre-delivery BMI and the accuracy of sonographic estimated fetal weight (EFW) in very preterm infants (<32 weeks gestation).

Methods: This retrospective study included singleton infants born between January 2010 and March 2023, at gestational ages 23 to 31 weeks, at a tertiary university-affiliated hospital. Absolute weight, percentage error, absolute percentage error, and overestimation and underestimation of EFW were compared between women with pre-delivery normal weight (BMI 18.

Perinatal Outcomes of Pregnancies with Borderline Oligohydramnios at Term.

Introduction: Limited evidence exists on borderline oligohydramnios. Our objective was to determine perinatal outcomes in uncomplicated term pregnancies with borderline oligohydramnios.

Methods: This retrospective analysis compared adverse perinatal outcomes among pregnancies during 2018-2022, between those with borderline oligohydramnios defined as amniotic fluid index (AFI) of 5.

Novel fetal phenotype of TAF8 deficiency.

TAF8 is part of the transcription factor TFIID complex. TFIID is crucial for recruiting the transcription factor complex containing RNA polymerase II. TAF8 deficiency was recently reported as causing a severe neurodevelopmental disorder in eight patients.

Indistinguishable photons from an artificial atom in silicon photonics.

Silicon is the ideal material for building electronic and photonic circuits at scale. Integrated photonic quantum technologies in silicon offer a promising path to scaling by leveraging advanced semiconductor manufacturing and integration capabilities. However, the lack of deterministic quantum light sources and strong photon-photon interactions in silicon poses a challenge to scalability.

Sonographic evaluation of retained products of conception within 48 h following delivery: a retrospective cohort study.

Objective: Early diagnosis of retained products of conception (RPOC) is critical for directing clinical management and for preventing associated complications. This study aimed to evaluate the utility of post-delivery ultrasound in patients with risk factors for RPOC.

Study Design: A retrospective cohort-study was conducted in a single tertiary university-affiliated hospital (January 2016-September 2022).

Bivalvular Endocarditis Due to Polymicrobial Coinfection with and : A Case Report and Review of the Literature.

Polymicrobial endocarditis is uncommon, and polymicrobial endocarditis in combination with is very rare. We herein describe an extremely rare case of polymicrobial bivalvular endocarditis due to coinfection with and in a 62-year-old male patient, and extensively review the relevant medical literature. To the best of our knowledge, only three similar cases have been previously reported.

Diagnostic accuracy and characteristics of symptomatic versus asymptomatic retained products of conception: A retrospective cohort study.

Objective: To assess the accuracy of diagnosing retained products of conception (RPOC) in symptomatic versus asymptomatic women, and to identify potential divergent ultrasound features between these groups.

Methods: This retrospective study included women aged 17-50 years who underwent hysteroscopy for suspected RPOC during 2018-2021. Clinical and sonographic data were analyzed, and multivariable linear regression models employed, to examine correlations between RPOC and sonographic findings, and to compare diagnostic accuracy between symptomatic and asymptomatic women.

Interstitial heterotopic pregnancy after bilateral total salpingectomy in IVF patients: a case report and literature review.

Objectives: Heterotopic pregnancy of an intrauterine pregnancy and an interstitial or stump pregnancy after bilateral salpingectomy is a rare complication of in vitro fertilization (IVF) that can lead to severe hemorrhage; prompt identification and management are important. The aim of this paper was to present a case report and an updated literature review of women who had had combined interstitial/stump and intrauterine pregnancies during an in an IVF cycle after total bilateral salpingectomy.

Material And Methods: We conducted a search in PubMed for reported heterotopic pregnancy, of a combined intrauterine pregnancy with an interstitial or stump pregnancy, in women who underwent IVF after bilateral salpingectomy.

Precision medicine in pharmacy: assessing pharmacogenomics competence among pharmacists and pharmacy students.

Background: Pharmacogenomics, a key component of precision medicine, aims to improve healthcare outcomes. As pharmacists play a pivotal role in this evolving field, an assessment of their preparedness to apply pharmacogenomics is imperative.

Methods: In this cross-sectional study, a validated questionnaire (Content Validity Ratio > 0.

A generic blood banking and transfusion process-oriented architecture for virtual organizations.

Background: Blood banks are an important part of healthcare systems. They embrace critical processes that start with donor recruitment and blood collection, followed by blood processing to produce different types of blood components used in transfusions, blood storage, blood distribution, and transfusion. Blood components must be generated at high quality, preserved safely, and transfused in a timely manner.

Design, synthesis, and biological evaluation of dinaciclib and CAN508 hybrids as CDK inhibitors.

The scaffolds of two known CDK inhibitors (CAN508 and dinaciclib) were the starting point for synthesizing two series of pyarazolo[1,5-a]pyrimidines to obtain potent inhibitors with proper selectivity. The study presented four promising compounds; 10d, 10e, 16a, and 16c based on cytotoxic studies. Compound 16a revealed superior activity in the preliminary anticancer screening with GI % = 79.

A new type of blood-brain barrier aminoacidopathy underlies metabolic microcephaly associated with SLC1A4 mutations.

Mutations in the SLC1A4 transporter lead to neurodevelopmental impairments, spastic tetraplegia, thin corpus callosum and microcephaly in children. SLC1A4 catalyses obligatory amino acid exchange between neutral amino acids, but the physiopathology of SLC1A4 disease mutations and progressive microcephaly remain unclear. Here, we examined the phenotype and metabolic profile of three Slc1a4 mouse models: a constitutive Slc1a4-knockout mouse; a knock-in mouse with the major human Slc1a4 mutation (Slc1a4-K256E); and a selective knockout of Slc1a4 in brain endothelial cells (Slc1a4tie2-cre).

Volume Measurement of the Cavum Septi Pellucidi: Normative Values Between 20 and 40 Weeks of Gestation.

Background: The cavum septi pellucidi (CSP) is a brain-enclosed cavity located on the midline between the two leaflets of the septum pellucidum that separates the lateral ventricles. This structure develops in the fetus from week 18 and can be seen up to week 37 in almost all cases and then begins to disappear.

Objectives: To measure and determine the normative values of the CSP volume in fetuses between 20 to 40 weeks of gestation.

Simultaneous removal of nutrients and biological pollutants via specialty absorbents in a water filtration system for watershed remediation.

To investigate watershed remediation within a Total Maximum Daily Load program, this study examined the field-scale filtration performance of two specialty absorbents. The goal was to simultaneously remove nutrients and biological pollutants along Canal 23 (C-23) in the St. Lucie River Basin, Florida.

Empowering early career pharmacists: Unleashing non-clinical competencies through pharmacy residency.

Introduction: Pharmacy residency programs traditionally prioritize clinical skills development. However, non-clinical competencies, such as leadership, conducting education, and innovation, are now emerging as pivotal factors in propelling pharmacists toward excellence in practice. The extent to which these non-clinical skills are effectively fostered by residency programs remains unclear.