Publications by authors named "Odara Medagedara"
Article Synopsis
- ARL13B is a small regulatory protein that influences the structure and function of cilia in male reproductive ductules, which are vital for fertility.
- Researchers knocked out the Arl13b gene in mouse models, leading to issues with the cilia's architecture and operations, which subsequently affected the ducts' ability to reabsorb and secrete fluids and caused inflammation.
- The study found that the absence of ARL13B resulted in a significant reproductive issue in males, indicating the critical role of cilia in maintaining reproductive health and offering insights into cilia-related disorders.
Volume electron microscopy (vEM) is a high-resolution imaging technique capable of revealing the 3D structure of cells, tissues, and model organisms. This imaging modality is gaining prominence due to its ability to provide a comprehensive view of cells at the nanometer scale. The visualization and quantitative analysis of individual subcellular structures however requires segmentation of each 2D electron micrograph slice of the 3D vEM dataset; this process is extremely laborious de facto limiting its applications and throughput.
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