Publications by authors named "Odalis Rodriguez-Ganen"
Introduction: Trimethoprim/sulfamethoxazole (TMP/SMX) is the antimicrobial of first choice in the treatment and prophylaxis of Pneumocystis jirovecii pneumonia (PCP) in immunocompromised patients, particularly in people living with human immunodeficiency virus (HIV). TMP/SMX use entails different adverse effects, and its association with early neutropenia is minimally documented. This study aimed to identify the risk of early neutropenia associated with TMP/SMX use in adults living with HIV in Mexico.
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- - The adverse effects of sodium colistimethate, particularly nephrotoxicity and neurotoxicity, vary widely among patients and are influenced by antibiotic resistance issues as it is often used as a last-resort treatment.
- - The rising problem of multidrug-resistant bacteria has led to an increased reliance on colistin, yet there are no randomized clinical trials confirming its safety and efficacy, leaving dosing decisions largely based on expert opinions and observational studies.
- - This review aims to delve into the mechanisms behind nephrotoxicity and bacterial resistance related to colistin, highlighting that further research is needed in these areas.
Antibiotic use in Mexico is characterized by high levels of consumption, irrational use in primary care services, and high rates of bacterial resistance that cause hospital infections. Changes are needed in the recommended method for reporting antimicrobial drug use, so that quantification can be carried out through drug utilization studies. Such studies, which make it possible to know which drugs are used in hospitals, require an accessible source of data on antimicrobial drug use with the least risk of biases, a single drug identification system, and the adoption of units of measure that can be extrapolated.
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