Publications by authors named "Octavian Maniuc"
Article Synopsis
- * Women with HF-CS tend to be older, have fewer prior heart issues, and lower rates of severe heart dysfunction compared to men, yet both genders received similar treatments.
- * Despite ranking equally in treatment use, the 30-day mortality rates were also comparable between sexes (around 53% for women and 51% for men), suggesting the need for further investigation into sex-specific treatment strategies.
Article Synopsis
- Researchers studied the use of mechanical circulatory support (MCS) in patients with non-ischaemic cardiogenic shock (CS), focusing on how left ventricular ejection fraction (LVEF) could influence patient outcomes.
- An analysis of 807 patients showed that while lower LVEF was linked to more severe shock, it didn't correlate with overall 30-day mortality risk; however, MCS appeared to reduce mortality in those with severely reduced LVEF (≤20%).
- The study suggests that incorporating LVEF into decision-making for MCS in non-ischaemic CS patients could improve patient outcomes by optimizing the benefit-risk ratio.
Article Synopsis
- - The study aimed to compare clinical characteristics and 30-day mortality rates between patients with de novo heart failure-related cardiogenic shock (HF-CS) and those with acute-on-chronic HF-CS, finding significant differences in outcomes.
- - An analysis of 1,030 patients revealed that while traditional markers of severity were similar, acute-on-chronic HF-CS was linked to higher mortality rates (55.9% vs. 45.5%) and greater severity of shock.
- - The results suggest that the chronicity of heart failure significantly influences the severity of cardiogenic shock, underlining the need to consider this factor in future clinical trials.
Article Synopsis
- VA-ECMO therapy helps patients with cardiogenic shock by restoring circulation but can lead to various complications affecting survival and neurological outcomes.
- A study analyzed data from 501 patients across 16 centers, revealing that over half experienced complications, especially women, with 40% mortality within 30 days.
- The findings indicate a need for better identification of patients at risk for complications to improve treatment strategies, as most adverse events correlate with worse prognosis.
Aims: Despite its high incidence and mortality risk, there is no evidence-based treatment for non-ischaemic cardiogenic shock (CS). The aim of this study was to evaluate the use of mechanical circulatory support (MCS) for non-ischaemic CS treatment.
Methods And Results: In this multicentre, international, retrospective study, data from 890 patients with non-ischaemic CS, defined as CS due to severe de-novo or acute-on-chronic heart failure with no need for urgent revascularization, treated with or without active MCS, were collected.
Background: It is currently unclear if active left ventricular (LV) unloading should be used as a primary treatment strategy or as a bailout in patients with cardiogenic shock (CS) treated with venoarterial extracorporeal membrane oxygenation (VA-ECMO).
Objectives: This study sought to evaluate the association between timing of active LV unloading and implantation of VA-ECMO with outcomes of patients with CS.
Methods: Data from 421 patients with CS treated with VA-ECMO and active LV unloading at 18 tertiary care centers in 4 countries were analyzed.
Background: To prevent complications, uncontrolled movement of the guidewire during a coronary intervention should be avoided. Unintentional withdrawal of the wire can result in the inability to recross a lesion with the risk of myocardial infarction. On the other hand, unintended forward pushing can lead to a coronary perforation.
View Article and Find Full Text PDFLeft Ventricular Unloading Is Associated With Lower Mortality in Patients With Cardiogenic Shock Treated With Venoarterial Extracorporeal Membrane Oxygenation: Results From an International, Multicenter Cohort Study.
Circulation
December 2020
Background: Venoarterial extracorporeal membrane oxygenation (VA-ECMO) is increasingly used to treat cardiogenic shock. However, VA-ECMO might hamper myocardial recovery. The Impella unloads the left ventricle.
View Article and Find Full Text PDFAims: From the various mechanical cardiac assist devices and indications available, the use of the percutaneous intraventricular Impella CP pump is usually restricted to acute ischaemic shock or prophylactic indications in high-risk interventions. In the present study, we investigated clinical usefulness of the Impella CP device in patients with non-ischaemic cardiogenic shock as compared with acute ischaemia.
Methods And Results: In this retrospective single-centre analysis, patients who received an Impella CP at the University Hospital Würzburg between 2013 and 2017 due to non-ischaemic cardiogenic shock were age-matched 2:1 with patients receiving the device due to ischaemic cardiogenic shock.
Long-term effects of migalastat therapy in clinical practice are currently unknown. We evaluated migalastat efficacy and biomarker changes in a prospective, single-center study on 14 patients with Fabry disease (55 ± 14 years; 11 men). After 1 year of open-label migalastat therapy, patients showed significant changes in alpha-galactosidase-A activity (0.
View Article and Find Full Text PDFObjectives: To evaluate potential risk factors for stroke or transient ischemic attacks (TIA) and to test the feasibility and efficacy of a Fabry-specific stroke risk score in Fabry disease (FD) patients without atrial fibrillation (AF).
Background: FD patients often experience cerebrovascular events (stroke/TIA) at young age.
Methods: 159 genetically confirmed FD patients without AF (aged 40 ± 14 years, 42.
Background: Accurate preoperative assessment of the aortic annulus dimension is crucial for successful transcatheter aortic valve implantation (TAVI). In this study we examined the accuracy of a novel method using two-dimensional transesophageal echocardiography (2D-TEE) for measurement of the aortic annulus.
Methods: We evaluated the theoretical impact of the measurement of the annulus diameter and area using the circumcircle of a triangle method on the decision to perform the procedure and choice of the prosthesis size.
Background: Accurate preoperative assessment of the aortic annulus dimension is crucial for successful transcatheter aortic valve implantation (TAVI). In this study we validated a new method using two-dimensional transesophageal echocardiography (2D-TEE) for measurement of the aortic annulus prior to TAVI.
Methods: We analysed 124 patients who underwent successful TAVI using a self-expandable prosthesis, divided equally into two groups; in the study group we used the cross sectional short axis 2D-TEE for measurement of the aortic annulus and in the control group we used the long axis 2D-TEE.