N-glycosylation state of TRPM8 protein revealed by terahertz spectroscopy and molecular modelling.

TRPM8 member of the TRP superfamily of membrane proteins participates to various cellular processes ranging from Ca uptake and cold sensation to cellular proliferation and migration. TRPM8 is a large tetrameric protein with more than 70% of its residues located in the cytoplasm. TRPM8 is N-glycosylated, with a single site per subunit.