Publications by authors named "Octavia-Oana Harich"
The COVID-19 pandemic has intensified concerns over bacterial infections and antimicrobial resistance, particularly in Romania. This systematic review explores bacterial infection patterns and resistance during the pandemic to address critical gaps in knowledge. A systematic review, following PRISMA guidelines, was conducted using databases such as PubMed and Scopus, focusing on studies of bacterial infections from 2020 to 2022.
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- - The research investigates the relationship between estimated glomerular filtration rates (eGFR), measured with the Schwartz equation, and renal scintigraphy in children with congenital kidney and urinary tract abnormalities (CAKUT), aiming to improve understanding of kidney function in this population.
- - A study of 94 pediatric CAKUT patients revealed significant differences in eGFR between the right and left kidneys, particularly in relation to body surface area, indicating a potential bias in standard measurements.
- - The findings suggest that current bedside eGFR methods may not be fully reliable for children with CAKUT, highlighting the need for more accurate diagnostic tools tailored for pediatric patients.
Article Synopsis
- The gut microbiome is really important for our health and can also affect our eyes through something called the gut-eye axis.
- When the gut bacteria are not balanced (called dysbiosis), it can lead to eye diseases like uveitis and glaucoma.
- Researchers are looking at ways to fix the gut microbiome, like using probiotics and other treatments, which might help protect and improve eye health.
Background: Pregnancy-related infections with the human herpes simplex virus (HSV) strains HSV-1 and HSV-2 are particularly noteworthy. There are numerous reported examples of intrapartum transmission of herpes infection, notwithstanding the extreme rarity of intrauterine transfer from mother to fetus. The purpose of this study was to evaluate the seroprevalence of HSV-1 and HSV-2 antibodies in pregnant women in the western region of Romania.
View Article and Find Full Text PDFNa/K ATPase is a protein involved in the active transport of ions across the cellular membrane. Ouabain is a cardiotonic glycoside that, by inhibiting the Na/K pump, interferes with cell processes mediated directly by the pump, but also indirectly influences other cellular processes such as cell cycle and proliferation, growth, cell differentiation, angiogenesis, migration, adhesion, and invasion. We used the SK-BR-3 breast cancer cell line, mesenchymal stem cells (MSCs), and tumor-associated fibroblasts (TAFs) in vitro to determine the effects of ouabain exposure on these cellular types.
View Article and Find Full Text PDFBreast cancer is the most prevalent neoplasia among women, with early and accurate diagnosis critical for effective treatment. In clinical practice, however, the subjective nature of histological grading of infiltrating ductal adenocarcinoma of the breast (DAC-NOS) often leads to inconsistencies among pathologists, posing a significant challenge to achieving optimal patient outcomes. Our study aimed to address this reproducibility problem by leveraging artificial intelligence (AI).
View Article and Find Full Text PDFPapillary renal cell carcinoma (PRCC) is defined by the WHO 2022 classification as a malignant tumor derived from the renal tubular epithelium. However, the WHO 2016 classification subdivided PRCC into two types, with type 1 PRCC showing papillae covered by a single layer of neoplastic cells, and type II PRCC, which can show multiple types of histologies and is more aggressive. The WHO 2022 classification eliminated the subcategorization of PRCC.
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