Spatial Single-Cell Mapping of Transcriptional Differences Across Genetic Backgrounds in Mouse Brains.

Genetic variation can alter brain structure and, consequently, function. Comparative statistical analysis of mouse brains across genetic backgrounds requires spatial, single-cell, atlas-scale data, in replicates-a challenge for current technologies. We introduce tlas-scale ranscriptome ocalization using ggregate ignatures (ATLAS), a scalable tissue mapping method.

Efficacy and safety of faricimab for neovascular age-related macular degeneration: a systematic review and network meta-analysis.

Objective: To evaluate the efficacy and safety of faricimab compared with other anti-vascular endothelial growth factor (anti-VEGF) agents in treating neovascular age-related macular degeneration (nAMD) patients.

Methods And Analysis: A systematic review (SR) was conducted up to January 2023. Network meta-analyses (NMA) were performed, including sensitivity and subgroup analyses for naïve population.

Bilateral retinal detachment in reactive arthritis: coincidence or association?

Retinal lesions are not typically found in reactive arthritis. However, a previous case report documented co-existing retinal detachment and reactive arthritis. We report here a similar case of a 32-year-old male patient with concurrent non-traumatic bilateral retinal detachment and HLA-B27 associated reactive arthritis after urogenital and gastrointestinal infections.

Fibrin glue sealing of pancreatic injuries, resections, and anastomoses.

Fibrin glue made with highly concentrated human fibrinogen and clotting factors was evaluated as a means of preventing pancreatic fistulas in 15 patients operated on for traumatic and nontraumatic conditions. Fibrin glue was applied directly to penetrating pancreatic injuries, pancreatic suture and staple lines in patients treated by partial resection, and pancreaticointestinal anastomoses. Postoperatively, no patient developed pancreatic fistulas, pancreatic abscesses, or pseudocysts.

Techniques of splenic preservation using fibrin glue.

Fibrin glue (FG) was used to achieve hemostasis of 16 splenic injuries in 14 patients. The etiologies of injury included five gunshot wounds, two stab wounds, four iatrogenic injuries, and five patients with blunt splenic trauma. The intraoperative blood loss averaged 1.

Comparison of hemodynamic and oxygen transport effects of dopamine and dobutamine in critically ill surgical patients.

Hemodynamic and oxygen transport effects of dopamine and dobutamine were studied in a series of 25 critically ill postoperative general surgical patients by a prospective, randomized crossover design after maximal response to fluids had been obtained. Dopamine increased MAP, HR, CI, PvO2, DO2, and Qsp while decreasing PaO2. Dobutamine increased HR, CI, SI, stroke work, DO2, VO2, and Qsp while decreasing PAWP and SVRI and PVRI.

Fibrin glue in renal and ureteral trauma.

Fibrin glue (FG) made with highly concentrated human fibrinogen and clotting factors was used to achieve hemostasis of fourteen renal injuries and to seal three ureteral anastomoses in 15 patients. The cause of injury included twelve gunshot wounds, four stab wounds, and one iatrogenic ureteral injury. The mean intraoperative blood loss was 1.

Selective management of posterior stab wounds.

Selective management of 473 patients with stab wounds limited to the posterior abdomen was reviewed. This group was composed of predominantly young, healthy men. Laporotomy was based primarily on clinical findings.