Supramolecular Structure of Sulfonamide-Substituted Silatranes: Quantum Chemical DFT Calculations.

The supramolecular structure of the crystal products--[2-chloro-2-(silatranyl)ethyl]-4-nitro-benzenesulfonamide and -chloro--[2-chloro-1-(silatran-1-yl-methyl)ethyl]benzene-sulfonamide was established by X-ray diffraction analysis data, FTIR spectroscopy and DFT quantum chemical calculations. Their crystal lattice is formed by cyclic dimers with intermolecular hydrogen NH∙∙∙O-Si bonds and CH∙∙∙O=S short contacts. The distribution of electron density in the monomers was determined using quantum chemical calculations of their molecular electrostatic potential (MESP) in an isolated state (in gas) and in a polar medium.

New Functional Alkoxysilanes and Silatranes: Synthesis, Structure, Properties, and Possible Applications.

The aza-Michael reaction of 3-aminopropyltriethoxysilane () and -silatrane () with acrylates affords functionalized silyl-(-) and silatranyl-(-) mono- and diadducts with up to a 99% yield. Their structure has been proved with IR and NMR spectroscopies, mass spectrometry and XRD analysis. The hydrolytic homo-condensation of triethoxysilanes - gives siloxanes -, which form complexes with Ag, Cu, and Ni salts.

New 3-Aminopropylsilatrane Derivatives: Synthesis, Structure, Properties, and Biological Activity.

The biologically active compound 3-aminopropylsilatrane (a compound with a pentacoordinated silicon atom) underwent an aza-Michael reaction with various acrylates and other Michael acceptors. Depending on the molar ratio, the reaction yielded Michael mono- or diadducts (11 examples) containing functional groups (silatranyl, carbonyl, nitrile, amino, etc.).

Silatrane-Sulfonamide Hybrids as Promising Antibacterial Agents.

At the A. E. Favorsky Irkutsk Institute of Chemistry, a series of silatrane-sulfonamide hybrids 1a-d and 2a-d was synthesized.

3-Aminopropylsilatrane and Its Derivatives: A Variety of Applications.

Silatranes arouse much research interest owing to their unique structure, unusual physical-chemical properties, and diverse biological activity. The application of some silatranes and their analogues has been discussed in several works. Meanwhile, a comprehensive review of the wide practical usage of silatranes is still absent in the literature.

Protatranes, effective growth biostimulants of hydrocarbon-oxidizing bacteria from Lake Baikal, Russia.

Under natural conditions, biodegradation processes proceed slowly, especially in regions with low temperature. To activate vital processes in hydrocarbon-oxidizing microorganisms at low temperatures, biologically active compounds can be employed as growth stimulants. A low-temperature (10 °C) study has shown that tris-(2 hydroxyethyl) ammonium arylchalcogenylacetates, "protatranes" exert an effect on the growth of hydrocarbon-oxidizing strains of and , isolated from natural oil seepage on Lake Baikal.

Cerebrospinal fluid sodium rhythms.

Background: Cerebrospinal fluid (CSF) sodium levels have been reported to rise during episodic migraine. Since migraine frequently starts in early morning or late afternoon, we hypothesized that natural sodium chronobiology may predispose susceptible persons when extracellular CSF sodium increases. Since no mammalian brain sodium rhythms are known, we designed a study of healthy humans to test if cation rhythms exist in CSF.

Effect of sphingomyelin versus dipalmitoylphosphatidylcholine on the extent of lipid oxidation.

Phospholipids with sites of unsaturation are targets of peroxidation. We investigated the effect of two types of lipids with identical headgroups, sphingomyelins (SMs) and dipalmitoylphosphatidylcholine (DPPC), on the extent of oxidation of stearoyl-arachidonoyl phosphatidylcholine (SAPC) with four double bonds. Peroxidation was induced with tert-butylhydroperoxide and FeCl(2) at 35 degrees C.