Publications by authors named "Oboh E"
Cryptosporidiosis is a diarrheal disease caused by the parasite resulting in over 100,000 deaths annually. Here, we present a structure-activity relationship study of the benzoic acid position (R) of pyrazolo[3,4-]pyrimidine lead SLU-2815 (), an inhibitor of parasite phosphodiesterase PDE1, resulting in the discovery of benzoxaborole SLU-10906 () as a benzoic acid bioisostere. Benzoxaborole is 10-fold more potent than against the parasite in a cell-based infection model (EC = 0.
View Article and Find Full Text PDFTo explore the association between COVID-19-related cancer treatment cancellations and the psychological health of cancer patients in Nigeria. We analyzed data collected from 15 outpatient cancer clinics, comprising 1,097 patients between April to July 2020. Study outcome was ten psychological impacts, including feeling down, stressed, and unable to access treatment due to COVID-19 (used as continuous and categorical variable (0-3,4-7,8+ events).
View Article and Find Full Text PDFArticle Synopsis
- Neurotrauma is a major health issue in Nigeria, leading to high rates of illness and death, prompting a systematic review to provide valuable nationwide data.
- The study analyzed data from 45,763 patients across 254 articles, revealing a predominance of traumatic brain injuries primarily caused by road traffic accidents, with most patients being young males.
- Despite 63.7% of traumatic brain injury patients showing favorable outcomes, only 20.9% of those with spinal injuries fared similarly, highlighting the critical need for focused interventions in managing neurotrauma in the country.
Background: Although women have made remarkable strides in several medical specialties in Sub-Saharan Africa, their presence and contribution to the development of neurosurgery remain limited. We sought to study the gender differences within Nigerian neurosurgery, identify challenges resulting from these differences, and recommend how African female neurosurgeons can maximize their effects in neurosurgery.
Methods: A structured online survey captured data on neurosurgical infrastructural capacity, workforce, and training from neurosurgical consultants and residents in neurosurgical centers in Nigeria.
Background: Like many low- and-middle-income countries in Africa, documented assessment of the neurosurgical workforce, equipment, infrastructure, and scope of service delivery in Nigeria is lacking. This study aimed to assess the capacity for the delivery of neurosurgical services in Nigeria.
Methods: An 83-question survey was disseminated to neurosurgeons and residents in Nigeria.
Article Synopsis
- The study reviews the development and challenges of vascular neurosurgery in Nigeria by analyzing literature from 1962 to 2021.
- A total of 56 articles were evaluated, involving 3203 patients, with a moderate to high risk of bias, indicating that most studies were retrospective cohort studies and case reports.
- The findings showed that cerebrovascular accidents predominated, particularly due to trauma, with favorable outcomes reported in 48% of cases and a mortality rate of 6%, highlighting key issues in neurovascular health in Nigeria.
Objective: Spinal pathologies are prevalent in Nigeria, though epidemiological data remains sparse. This systematic review used pooled patient-level data from across the country to generate a standardized epidemiological reference.
Methods: Four research databases and gray literature sources were searched.
Article Synopsis
- * A systematic review identified 147 studies and over 5,700 patients, revealing a significant rise in the types of tumors diagnosed and the use of imaging techniques like CT and MRI.
- * The findings emphasize the need for further research to improve understanding and enhance neuro-oncologic care in Nigeria, particularly in underrepresented treatment options like chemotherapy.
Objective: There has been a modest but progressive increase in the neurosurgical workforce, training, and service delivery in Nigeria in the last 2 decades. However, these resources are unevenly distributed. This study aimed to quantitatively assess the availability and distribution of neurosurgical resources in Nigeria while projecting the needed workforce capacity up to 2050.
View Article and Find Full Text PDFObjective: Despite 6 decades of existence, neurosurgery is still in the developing stages in Nigeria. In this era of collaborative health system capacity-building in low- and middle-income countries, this article reviews past efforts and future prospects for collaborative neurosurgical development in Nigeria.
Methods: A bibliometric review of the Nigerian neurosurgical literature and data from a structured survey of Nigerian neurosurgeons and residents provided details of current local and international collaborations for neurosurgical research, service delivery, training, and capacity building.
Objective: Despite the well-known neurosurgical workforce deficit in Sub-Saharan Africa, there remains a low number of neurosurgical training programs in Nigeria. This study sought to reassess the current status of specialist neurosurgical training in the country.
Methods: An electronic survey was distributed to all consultant neurosurgeons and neurosurgery residents in Nigeria.
Objective: This study aims to provide a comprehensive overview of pediatric neurosurgery in Nigeria, since 1962, by assessing epidemiological data, management strategies, and case outcomes.
Methods: A systematic bibliometric review of Nigerian neurosurgical literature was reported with the PRISMA guidelines. The Risk of Bias Assessment Tool was applied to all nonrandomized studies, and a descriptive analysis was performed for all variables.
Objective: This study investigates the scope, trends, and challenges of neurosurgical research in Nigeria since inception of the specialty in 1962.
Methods: A bibliometric review of the neurosurgical literature from Nigeria was performed. Variables extracted included year and journal of publication, article topic, article type, research type, study design, article focus area, and limitations.
Our previous work identified compound (SLU-2633) as a potent lead compound toward the identification of a novel treatment for cryptosporidiosis, caused by the parasite (EC = 0.17 μM). While this compound is potent and orally efficacious, the mechanism of action and biological target(s) of this series are currently unknown.
View Article and Find Full Text PDFCryptosporidiosis is a diarrheal disease particularly harmful to children and immunocompromised people. Infection is caused by the parasite Cryptosporidium and leads to dehydration, malnutrition, and death in severe cases. Nitazoxanide is the only FDA approved drug but is only modestly effective in children and ineffective in immunocompromised patients.
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- - The study investigated how COVID-19 impacted telehealth for cancer patients in Nigeria, analyzing data from over 1,000 patients across 15 outpatient clinics between April and July 2020.
- - Findings revealed that 12.6% of patients had their routine follow-ups changed to virtual visits, with significant associations found among those who had surgical and treatment delays or less frequent interactions with healthcare providers.
- - The conclusion highlighted the increased reliance on virtual care during the pandemic, particularly among patients facing treatment disruptions, emphasizing the need for ongoing research into teleoncology in Nigeria.
Background: The use of Highly Active Anti-Retroviral Therapy (HAART) has revolutionized the course and pattern of eye diseases in persons with HIV/AIDS which ultimately affects the visual status.
Objective: To determine the prevalence and etiology of visual impairment and blindness in people with HIV/AIDS on HAART in Benin City, Nigeria.
Methodology: This was a descriptive hospital-based study on all HIV/AIDS patients on HAART in the United States President's Emergency Plan for AIDS Relief (PEPFAR) clinics of University of Benin Teaching Hospital seen from July to August 2018 and Central Hospital, Benin City in October 2019.
Article Synopsis
- The global COVID-19 pandemic led to changes in health care delivery, prompting a study on how these modifications impacted oncology services in Nigeria.
- Researchers surveyed 1,072 cancer patients across 15 treatment centers, revealing that 17.3% experienced disruptions in care and over half faced difficulties accessing treatment.
- The findings indicated that vulnerable groups, particularly older patients and those with prostate cancer, were most affected, highlighting the need for policies to reduce service disruptions while ensuring patient safety during the pandemic.
Cryptosporidiosis is caused by infection of the small intestine by parasites, resulting in severe diarrhea, dehydration, malabsorption, and potentially death. The only FDA-approved therapeutic is only partially effective in young children and ineffective for immunocompromised patients. Triazolopyridazine MMV665917 is a previously reported anti- screening hit with efficacy but suffers from modest inhibition of the hERG ion channel, which could portend cardiotoxicity.
View Article and Find Full Text PDFPurpose: Comorbidities have been indicated to influence cancer care and outcome, with strong associations between the presence of comorbidities and patient survival. The objective of this study is to determine the magnitude and pattern of comorbidities in Nigerian cancer populations, and demonstrate the use of comorbidity indices in predicting mortality/survival rates of cancer patients.
Methods: Using a retrospective study design, data were extracted from hospital reports of patients presenting for oncology care between January 2015 and December 2016 at two tertiary health facilities in Lagos, Nigeria.