Publications by authors named "Obiadada Ugochukwu"
Article Synopsis
- Alzheimer's disease and osteoporosis are common age-related conditions linked by unknown molecular mechanisms, prompting this study.
- Researchers conducted network analysis of brain and bone RNA data from several participants to identify shared molecular pathways.
- Findings revealed interconnected gene modules between both diseases, particularly highlighting the role of Wnt signaling, suggesting potential avenues for treatment and biomarker development.
Lewy body dementia (LBD), a class of disorders comprising Parkinson's disease dementia (PDD) and dementia with Lewy bodies (DLB), features substantial clinical and pathological overlap with Alzheimer's disease (AD). The identification of biomarkers unique to LBD pathophysiology could meaningfully advance its diagnosis, monitoring, and treatment. Using quantitative mass spectrometry (MS), we measured over 9,000 proteins across 138 dorsolateral prefrontal cortex (DLPFC) tissues from a University of Pennsylvania autopsy collection comprising control, Parkinson's disease (PD), PDD, and DLB diagnoses.
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- - The study examined socioeconomic disparities in the use of adjuvant radiotherapy (RT) for patients with atypical meningioma (AM) and compared survival rates of those receiving RT versus those who did not at 12 and 60 months.
- - Results showed that older patients (over 65), women, those living in the Southern USA, those farther from treatment facilities, and uninsured individuals were less likely to receive RT, while males were more likely to receive it.
- - Overall, the findings indicated that adjuvant RT significantly improved survival rates, highlighting the need to address these disparities in treatment access.
Article Synopsis
- * Using mass spectrometry, researchers analyzed over 9,000 proteins from the dorsolateral prefrontal cortex tissues of individuals diagnosed with various conditions, including control subjects, to identify specific protein changes associated with LBD.
- * The study found distinct co-expression patterns of proteins in LBD compared to AD, revealing specific synaptic and inflammatory alterations in LBD, which could serve as potential biomarkers for clinical use.
We developed and validated a method for the extraction, identification, and quantitation of four nitrofuran metabolites, 3-amino-2-oxazolidinone (AOZ), 3-amino-5-morpholinomethyl-2-oxazolidinone (AMOZ), semicarbazide (SC), and 1-aminohydantoin (AHD), as well as chloramphenicol and florfenicol in a variety of seafood commodities. Samples were extracted by liquid-liquid extraction techniques, analyzed by ultrahigh-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS), and quantitated using commercially sourced, derivatized nitrofuran metabolites, with their isotopically labeled internal standards in-solvent. We obtained recoveries of 90-100% at various fortification levels.
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