[The complex serologic diagnosis of typhoid fever].

A parallel serological study of the blood sera of typhoid patients has been made by the methods of countercurrent immunoelectrophoresis and the indirect hemagglutination test with a view to establish the presence of soluble typhoid antigens and their corresponding antibodies. As shown in this study, the occurrence of Salmonella typhi O- and Vi-antigens is essentially higher than the content of specific antibodies in diagnostically significant titers.

[Characteristics of the immunity in typhoid infection associated with opisthorchiasis].

Typhoid infection developing in persons with opisthorchiasis is characterized by the appearance of pronounced systemic immunity, that ensures a more favorable clinical course of this infection and promotes a decrease in the occurrence of diarrheal phenomena and bacteremia. At the same time, in typhoid patients, simultaneously affected by opisthorchiasis, a more intensive release of the infective agent into the environment is observed. This seemingly demonstrates the presence of disturbances in the local protective mechanisms regulating the process of the release of bacteria on the level of the gastrointestinal tract.

[The function of Salmonella typhi at different stages in the pathogenesis of typhoid infection].

The complex study of the adhesive, colicinogenic and antigenic properties of S. typhi of different origin has revealed that adhesive properties can be observed more frequently in the strains isolated from the blood and bile and are completely absent in the strains isolated from feces. S.

[Pathogenetic and immunological characteristics of different forms of the Salmonella typhi carrier state].

Infectious granulomas with macrophages containing Salmonella typhi have been detected in the immune organs of the intestine of typhoid patients by means of morphological investigation techniques, immunofluorescent and electron microscopy. This suggests that typhoid granulomas form the basis of S. typhi primary carriership complicated by the relapses of this infection in cases of weakened cell-mediated immunity, which is proved by a decrease in the level of T-lymphocytes and by increased leukocyte migration index in relapses of typhoid fever and in S.