Safety and Outcomes of Percutaneous Dilatational Tracheostomy in Patients with Hematologic Malignancies: A Retrospective Cohort Study.

: Patients with hematologic malignancy (HM) often experience high rates of thrombocytopenia, thrombocytopathy, anemia, leukopenia, and coagulopathy, which can significantly increase the risk of procedural and postoperative complications. This study aimed to evaluate the safety and outcomes of percutaneous dilatational tracheostomy (PDT) in critically ill patients with HM. : This retrospective cohort study included patients with HM who underwent PDT between 2012 and 2023 at a tertiary academic center.

Alopecia Areata Is Associated with an Increased Risk for Prediabetes and Obesity: A Nationwide Case-Control Study.

Alopecia areata (AA) is a non-scarring inflammatory hair loss condition associated with various immune-mediated comorbidities. Prediabetes, characterized by elevated blood glucose levels not yet high enough to be classified as diabetes, significantly increases the risk of developing type 2 diabetes mellitus (T2DM) and cardiovascular complications. The associations between AA obesity and prediabetes have long been investigated in an attempt to identify preventable risk factors, yet the literature is relatively scarce and inconclusive.

Water, Solute, and Ion Transport in De Novo-Designed Membrane Protein Channels.

Biological organisms engineer peptide sequences to fold into membrane pore proteins capable of performing a wide variety of transport functions. Synthetic de novo-designed membrane pores can mimic this approach to achieve a potentially even larger set of functions. Here we explore water, solute, and ion transport in three de novo designed β-barrel membrane channels in the 5-10 Å pore size range.

Vomer-to-nasopharyngeal widths and post-adenoidectomy outcomes in children: A prospective blinded study.

Objectives: The vomer is an essential component of the nasopharynx. Although variations in vomer width(VW) and nasopharyngeal width(NW) can be observed, their clinical significance on post-adenoidectomy outcomes in children with sleep-disordered breathing and obstructive sleep apnea(SDB-OSA) remains uncertain. The primary outcome was to investigate the association between VW and post-adenoidectomy clinical improvement.

Phase II Trial of Nivolumab Plus Doxorubicin, Vinblastine, Dacarbazine as Frontline Therapy in Older Adults With Hodgkin Lymphoma.

Purpose: We conducted a phase I/II study evaluating nivolumab plus doxorubicin, vinblastine, dacarbazine (N-AVD) as frontline therapy for treatment-naïve older adults (OA) with classical Hodgkin lymphoma (cHL; ClinicalTrials.gov identifier: NCT03033914).

Methods: Patients age ≥60 years with newly diagnosed, any stage, cHL were treated with six cycles of AVD at standard doses plus nivolumab 240 mg intravenously once every 2 weeks (on days 1 and 15) of each cycle.

Nanoscale dynamics of Dynamin 1 helices reveals squeeze-twist deformation mode critical for membrane fission.

Dynamin 1 (Dyn1) GTPase, a principal driver of membrane fission during synaptic endocytosis, self-assembles into short mechanoactive helices cleaving the necks of endocytic vesicles. While structural information about Dyn1 helix is abundant, little is known about the nanoscale dynamics of the helical scaffolding at the moment of fission, complicating mechanistic understanding of Dyn1 action. To address the role of the helix dynamics in fission, we used High-Speed Atomic Force Microscopy (HS-AFM) and fluorescence microscopy to track and compare the spatiotemporal characteristics of the helices formed by wild-type Dyn1 and its K44A mutant impaired in GTP hydrolysis on minimal lipid membrane templates.

[CEREBROSPINAL FLUID (CSF) LEAK FOLLOWING COVID-19 NASAL SWAB: A CASE REPORT].

Coronavirus 19 (Covid-19) emerged as a global pandemic with over 12,900 deaths in Israel alone. On average, more than 40,000 tests to detect the virus daily were performed in Israel. According to the US Centers for Disease Control and Prevention (CDC), the recommended methods for testing are nasopharyngeal swab, mid-turbinate, or anterior nasal swab specimen.

Factors associated with early mortality in pediatric tracheostomy placement: a retrospective cohort study.

Unlabelled: To investigate the factors associated with early mortality and complications in children who receive a tracheostomy placement. This was a retrospective study at a tertiary referral center. Children who underwent tracheostomy between 2012 and 2023 was included.

Advances in Targeted Therapy: Addressing Resistance to BTK Inhibition in B-Cell Lymphoid Malignancies.

B-cell lymphoid malignancies are a heterogeneous group of hematologic cancers, where Bruton's tyrosine kinase (BTK) inhibitors have received FDA approval for several subtypes. The first-in-class covalent BTK inhibitor, Ibrutinib, binds to the C481 amino acid residue to block the BTK enzyme and prevent the downstream signaling. Resistance to covalent BTK inhibitors (BTKi) can occur through mutations at the BTK binding site (C481S) but also other BTK sites and the phospholipase C gamma 2 (PLCγ2) resulting in downstream signaling.

Identification of the TRPA1 cannabinoid-binding site.

Chronic pain accounts for nearly two-thirds of conditions eligible for medical cannabis licenses, yet the mechanisms underlying cannabis-induced analgesia remain poorly understood. The principal phytocannabinoids, the psychoactive Δ-tetrahydrocannabinol (THC) and non-psychoactive cannabidiol (CBD), exhibit comparable efficacy in pain management. Notably, THC functions as an agonist of cannabinoid receptor 1 (CB1), whereas CBD shows minimal activity on CB1 and CB2 receptors.

Marine heatwaves and commercial fishing in New Zealand.

A marine heatwave (MHW) is an atypical and relatively short period of warmer Sea Surface Temperature (SST) which may be disruptive to marine life. Changes brought about by MHWs can reshape marine ecosystems in ways that have an economic impact on their users. MHWs are expected to become more frequent, longer, and more intense due to anthropogenic climate change.

Search for Leptonic Decays of Dark Photons at NA62.

The NA62 experiment at CERN, configured in beam-dump mode, has searched for dark photon decays in flight to electron-positron pairs using a sample of 1.4×10^{17} protons on dump collected in 2021. No evidence for a dark photon signal is observed.

Neural network reconstruction of the left atrium using sparse catheter paths.

Purpose: Catheter-based radiofrequency ablation for pulmonary vein isolation has become the first line of treatment for atrial fibrillation in recent years. This requires a rather accurate map of the left atrial sub-endocardial surface including the ostia of the pulmonary veins, which requires dense sampling of the surface and currently takes more than 10 min. The focus of this work is to provide left atrial visualization early in the procedure to ease procedure complexity and enable further workflows, such as using catheters that have difficulty sampling the surface.

The impact of sequence periodicity on DNA mechanics: investigating the origin of A-tract's curvature.

Periodic sequences in phase with DNA helical shape are prevalent in genomes due to their capacity to modulate DNA elasticity on a global scale. However, how this occurs is not well understood. We use all-atom molecular dynamics simulations on 40 bp DNA fragments to assess the effect of periodicity on bending, twisting, and stretch elasticity.