Publications by authors named "Obdulio G Miguel"

Article Synopsis
  • * Studies on Symplocos tetrandra using light and scanning electron microscopy revealed key anatomical features, such as calcium oxalate crystals and specialized stomata, useful for species identification.
  • * The presence of these metabolites and unique anatomical markers indicates potential for further pharmacological research and taxonomic classification of S. tetrandra.
View Article and Find Full Text PDF

The order Sapindales is comprised of nine families and in Brazil it is represented by six, including Rutaceae Juss., which constitutes the largest group of this order. A variety of species of Zanthoxylum L.

View Article and Find Full Text PDF

Gabiroba, a native fruit in Brazil's Atlantic Forest region, has significant nutritional and therapeutic properties. However, due to its seasonality, consumption by the population is limited. Thus, the development of gabiroba byproducts would add significant value to the food and therapeutic industries.

View Article and Find Full Text PDF

Viral diseases are the cause of many global epidemics, leading to deaths, affecting the quality of life of populations, and impairing public health. The limitations in the treatment of viral diseases and the constant resistance to conventional antiviral treatments encourage researchers to discover new compounds. In this perspective, this literature review presents isolated molecules and extracts of natural products capable of inhibiting the activity of the nonstructural protein that acts as the RNA-dependent RNA polymerase.

View Article and Find Full Text PDF

This article describes the morpho-anatomies of the leaves and stems of Ocotea paranaensis Brotto, Baitello, Cervi & Santos (Lauraceae) using light and scanning electron microscopy. The main anatomical features characterizing the species are the presence of simple non-glandular trichomes in the leaves and stems, large secretory cells in the leaves, flat-convex petioles with two small lateral ribs, brachysclereids in the stem cortex and pith, and the presence of starch grains and various types of calcium oxalate crystals in the pith. Histochemical tests indicated the presence of lignin in stone cells, fibers, and xylem.

View Article and Find Full Text PDF

The aim of this study was to investigate the chemical composition, mineral content and report the effect of gastrointestinal digestion on the proteins, phenolics, flavonoids and antioxidant activity of morphological parts of Amaranthus viridis (AV). The macronutrients found in the greatest quantity were proteins (leave, inflorescence and seeds) and fiber (roots and stem). The main minerals were calcium, potassium, iron and zinc.

View Article and Find Full Text PDF

The genus exhibits a variety of pharmacological, antibacterial and antioxidant effects. The aim of the present study was to evaluate the antioxidant potential and antibacterial properties of the ethyl acetate fraction of leaves. Isolation and identification of the phenolic compounds from the fraction was also carried out.

View Article and Find Full Text PDF

Introduction: Aedes aegypti is the main vector of dengue and yellow fever. Recently, the use of plant-sourced larvicides has gained momentum.

Methods: The hydroethanolic extracts and fractions ofOcotea nutansleaves and stems were bioassayed to determine the larvicidal efficacy of these samples.

View Article and Find Full Text PDF

Studies have demonstrated that diet rich in cruciferous vegetables of the Brassicaceae family can reduce the risk of cardiovascular diseases and oxidative stress levels. Nasturtium officinale (Brassicaceae), commonly known as watercress is a perennial dicotyledonous plant usually found close to water. Although previous investigations have demonstrated the beneficial effects of watercress on hypercholesterolemia in animal studies, until now no such studies have been conducted with humans, up to this time.

View Article and Find Full Text PDF

The growing interest in the discovery of new compounds from medicinal plants justifies the study of phytochemical components of these plants and their biological activities. The genus exhibits a variety of pharmacological, antimicrobial and antioxidant effects. The aim of the present study was to evaluate the antioxidant potential and antimicrobial properties of the ethyl acetate fraction of leaves.

View Article and Find Full Text PDF

Natural products, especially plants, have been investigated as sources of new substances with antimicrobial properties. In this context, the genus is extensively researched for presenting such activities. This work aims to evaluate the antifungal, antibacterial, and antioxidant properties of extracts and fractions of stems of , also to characterize two phenolic compounds.

View Article and Find Full Text PDF

It is well established that plants from the Brassicaceae family, particularly watercress, have been associated to reduce oxidative DNA damage. Nasturtium officinale R. Br (watercress) contains glucosinolates, with anti-inflammatory action and protective effect on human health against oxidative stress.

View Article and Find Full Text PDF
Article Synopsis
  • Various factors like temperature, pH, and culture medium influence the growth of fungi and the production of important compounds.
  • Studies on the metabolites produced by specific fungi are limited, although they have potential for biotechnological use.
  • The highest growth of mycelial mass from a certain fungus occurred at 24°C using potato dextrose and malt extract media, and the disaccharide α-α-trehalose was newly identified in this genus through X-ray diffraction analysis.
View Article and Find Full Text PDF

Several essential oils have allelochemicals with phytotoxic effects. species are producers of secondary metabolites with biological potential. In the present study, chemical composition of the essential oil extracted from aerial parts of Linnaeus was evaluated by gas chromatography and the phytotoxicity of the oil on seeds was evaluated for the first time.

View Article and Find Full Text PDF

The aim of this work is to develop a W/O/W multiple emulsion with gallic acid in the internal aqueous phase (W). A quantification method for gallic acid using HPLC-UV was developed and validated. In the first step, a simple W/O emulsion was prepared with distilled water, polyglycerol polyricinoleate, sodium chloride, gallic acid and pH 5.

View Article and Find Full Text PDF

Bixin is the main natural apocarotenoid extracted from the seeds of widely used as a cosmetic and textile colorant. Despite the description of several pharmacological properties of extracts, little has been studied regarding the pharmacological properties of bixin. Then we aimed to investigate the potential anti-inflammatory and antinociceptive effect of bixin in preclinical models of inflammation and acute pain.

View Article and Find Full Text PDF

The Lauraceae family is predominantly found in Asia and in the rainforests of the Americas, and consists mostly of aromatic trees. Being an essential oil producer, this family is used in the food, pharmaceutical, and cosmetic industries. This work presents a systematic review of the chemical composition and bioactivity of the essential oils from the Lauraceae family.

View Article and Find Full Text PDF
Article Synopsis
  • Diplodia pinea was tested for its ability to inhibit the growth of several fungi, including Armillaria sp. and Botrytis cinerea, using a method where two fungi strains are grown together.
  • The study found that D. pinea significantly inhibited the growth of all tested fungi, showing a range of 30.75% to 98.37% inhibition and a moderate antagonist activity index of 14.5.
  • Chemical analysis identified certain compounds in D. pinea, such as steroids and phenolic compounds, which likely contribute to its ability to compete for resources with other fungi.
View Article and Find Full Text PDF

There have been few studies on the pharmacological properties of var. , a native Brazilian species popularly known as "fruto-de-pombo." The aim of this study was to investigate the scavenging capacity of emodin, physcion, and the ethanolic crude extract of var.

View Article and Find Full Text PDF
Article Synopsis
  • - Antimicrobial resistance is a serious global health issue, as common pathogens have become resistant to treatments, increasing the need for new antimicrobial agents from natural sources.
  • - The study focuses on the genus, which includes about 1000 species known for their medicinal properties, including antidiabetic and antibacterial effects, and aims to compile data on their phytochemical composition and antimicrobial activity.
  • - After analyzing 93 studies, results indicate that these species are rich in beneficial compounds like flavonoids and tannins, which contribute to their antimicrobial properties, although some species demonstrate significant cytotoxic effects.
View Article and Find Full Text PDF

Background: Plants and their parts are a part of life in many Brazilian communities, as observed in the jackfruit. The jackfruit seeds are consumed, usually, as roasted, boiled, steamed, and are eaten as a snack.

Objective: The present study was carried out to identify the seeds toxicity and cytotoxic activity.

View Article and Find Full Text PDF
Article Synopsis
  • This study explored the cytotoxic effects of Bacharis milleflora essential oil on Jurkat, Raji, and HL-60 cancer cells, examining how it affects cell death mechanisms.
  • Key volatile compounds identified in the oil include bicyclogermacrene, germacrene D, (E)-caryophyllene, and α-humulene, which contributed to a significant decrease in cell proliferation, especially in Raji cells.
  • The essential oil caused cell cycle arrest and fragmentation, inducing apoptosis and some necrosis, with a selectivity index of 3.97, showing its potential for therapeutic applications against certain tumors.
View Article and Find Full Text PDF