Publications by authors named "Oates J"

Background: Reducing the prevalence and consequences of anxiety following childbirth (postpartum anxiety) is a strategic priority in the UK and many similar nations; a comprehensive review of risk factors can support the development of interventions and guide further research.

Methods: This registered systematic review was guided by 'Preferred Reporting Items for Systematic Reviews and Meta-Analyses' (PRISMA) and analysed using 'Synthesis Without Meta-analysis' (SWiM) to answer the question; 'What factors have been reported to increase the risk of maternal postpartum anxiety (PPA) in Australia, Europe, and North America?'. MEDLINE and PsycINFO were searched for relevant research from Australia, Europe, and North America, published up to July 2021.

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Background: Support for NHS staff was vital during the COVID-19 pandemic and Team Time was developed as an adaptation of Schwartz Rounds™ - a well-evidenced, facilitated group intervention. Building on the existing evidence base for Schwartz Rounds implementation, this study aims to understand the key factors associated with Team Time implementation and sustainability in this context.

Methods: Twenty semi-structured interviews were conducted within 10 NHS acute, community and mental health organisations that ran Team Time during the pandemic: six with no prior experience of Schwartz Rounds and four that ran Schwartz Rounds prior to the pandemic.

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Background: Gender diverse people may experience discomfort with the sound of their voice. Additionally, their psychological wellbeing, closely connected to a person's identity, or perspective of themselves, is often reduced. A primary goal of gender affirming healthcare is to support clients' psychological wellbeing.

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Objectives: This review aims to explore potential associations between immunological biomarkers and phonotraumatic vocal fold lesions.

Study Design: Scoping review.

Methods: Ovid MEDLINE, CINAHL, PubMed, Proquest Theses and Dissertations, Scopus, and Web of Science were searched using the terms "vocal fold" and "inflammatory marker" initially, and later "development" and "phonotraumatic lesion.

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Obesity is a risk factor for increased lung damage and disease severity during influenza virus infection. White adipose tissue (WAT) inflammation is a key driver of disease pathogenesis in obesity. Whether and how obesity modifies lung and WAT immune cell character and function in obesity to amplify influenza disease severity remains unknown.

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Article Synopsis
  • The study validated algorithms using Medicare claims data to accurately identify Systemic Lupus Erythematosus (SLE) and lupus nephritis (LN), aiming to improve the Lupus Index for research purposes.
  • Researchers analyzed retrospective data from a South Carolina cohort and compared algorithm performance based on ICD-10 codes, finding that the best results for SLE were from two ICD-10 codes with or without a 30-day gap.
  • The results emphasize the need for specific algorithms tailored to research goals, facilitating better geographical resource allocation and studies on health disparities and clinical trial site identification.
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Background: Menopause involves a range of bodily changes, with impacts on physical and psychological well-being. Around half of the postmenopausal women experience genitourinary syndrome of menopause (GSM). Fractional CO laser treatment can promote tissue regeneration in the vaginal wall to potentially assist with managing GSM.

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Objective: Systemic lupus erythematosus (SLE) affects nine women to every man worldwide, and these patients are at greater risk for cardiovascular disease (CVD) morbidity and mortality. Clinical studies have demonstrated that patients with SLE are more likely to develop CVD, including cardiac and vascular dysfunction. Although many preclinical models of SLE are available, including treatment with Toll-like receptor (TLR) 7/8 agonists, a consistent preclinical model of SLE-like CVD with systemic, cardiac, renal, and cerebral endothelial activation and cardiac dysfunction has yet to be described.

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Objective: Health literacy is an important social determinant of health, with limited health literacy associated with worse health outcomes. This study examined the associations between limited health literacy with patient-reported outcomes and disease activity/damage among 267 Black women with active systemic lupus erythematosus (SLE) enrolled in the Peer Approaches to Lupus Self-Management (PALS) program.

Methods: The three-item Chew Health Literacy Screening was used to dichotomize those reporting in the "limited" range on any item with outcomes compared via generalized linear models.

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Nitric oxide (NO) is widely recognized for its role in regulating renal function and blood pressure. However, the precise mechanisms by which NO affects renal epithelial cells remain understudied. Our previous research has shown that NO signaling in glomerular podocytes can be initiated by Angiotensin II (ANG II) but not by ATP.

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Aim: Speech pathology is the first-line treatment for inducible laryngeal obstruction (ILO) and involves behavioral techniques to address symptoms and modify maladaptive laryngeal postures. Benefit from speech pathology is reliant on patients engaging in treatment sessions, regular home practice, and generalizing techniques to everyday activities. There is limited research exploring engagement in speech pathology treatment for ILO, particularly from the patient perspective.

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Objectives: To investigate acoustic outcomes of gender-affirming voice training for trans women wanting to develop a female sounding voice and to describe what happens acoustically when male sounding voices become more female sounding.

Study Design: Prospective treatment study with repeated measures.

Methods: N = 74 trans women completed a voice training program of 8-12 sessions and had their voices audio recorded twice before and twice after training.

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Background: The popularity of labiaplasty has increased over the last decade and patients consistently report high levels of satisfaction with outcomes. Specifically, patients generally experience improved sexual satisfaction, but there is very limited research on the impacts on intimate relationships more broadly, even though these experiences are often crucial to women's lives.

Objectives: The aim of this study was to conduct an in-depth qualitative exploration of the impacts of labiaplasty on intimate relationship quality.

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Background: Higher education institutions (HEIs) are seeking effective ways to address the rising demand for student mental health services. Peer support is widely considered a viable option to increase service capacity; however, there are no agreed definitions of peer support, making it difficult to establish its impact on student mental health and well-being.

Aims: This systematic review aims to better understand and evaluate peer support in HEIs.

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Article Synopsis
  • Vertical transmission of obesity plays a significant role in the ongoing obesity epidemic and related metabolic diseases, yet current models fail to accurately reflect human obesity.
  • This study introduces a new mouse model that simulates "human-like" obesity by using a specific diet and housing conditions, revealing that maternal obesity negatively impacts neonatal survival, increases offspring fat accumulation, and heightens their risk for obesity-related diseases.
  • The findings suggest that severe maternal obesity alters the offspring's microbiome and creates a harmful inflammatory environment during pregnancy, which is supported by similar patterns observed in a human birth cohort study.
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Purpose: Although speech-language pathologists have provided gender-affirming voice training for trans women since the 1970s, evidence for this training's effectiveness remains weak. Our study aimed to redress limitations of earlier studies and evaluate voice training effects on outcomes important to trans women.

Method: Seventy-four trans women (19-54 years old) who wanted a more female-sounding voice were recruited through two health facilities and provided with an eight- to 12-session voice training program based on contemporary literature, usual clinical practice, and client-centered care principles.

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  • Influenza virus-induced pneumonia poses significant public health risks, with obesity, metabolic diseases, and female sex identified as independent factors worsening the disease.
  • The lack of experimental models for studying severe obesity in female mice has limited research, but this study successfully induced severe obesity in female mice using a high-fat diet and thermoneutral housing.
  • The findings reveal that while traditionally lean mice show similar responses to influenza, introducing severe obesity and metabolic disease in female mice results in disease severity comparable to that of obese males, highlighting the critical role of these factors in influenza severity.
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Objective: Disparities in pregnancy outcomes among women with SLE remain understudied, with few available racially diverse datasets. We sought to identify disparities between Black and White women in pregnancy outcomes within academic institutions in the United States.

Methods: Using the Common Data Model electronic medical record (EMR)-based datasets within the Carolinas Collaborative, we identified women with pregnancy delivery data (2014-2019) and ≥1 SLE International Classification of Diseases 9 or 10 code (ICD9/10) code.

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  • Increased mechanical stretch of endothelial cells contributes to cardiovascular and renal diseases and its effects vary between sexes.
  • Endothelial cells, while not typical antigen-presenting cells, can still express important molecules (MHCs) that influence immune responses when stimulated by cytokines.
  • Experiments showed that in male renal endothelial cells, mechanical stretch decreased MHC I expression but increased it in females, with both sexes showing upregulation of MHC II, indicating sex-dependent responses to mechanical stress.
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Background: The demand for labiaplasty has increased rapidly over the last 10 to 15 years. Women's reasons for pursuing the procedure have been thoroughly documented in the literature, but other preoperative aspects are less well defined. These include women's expected outcomes, concerns about having the surgery, and the impacts of support from others in their personal lives as well as their treating team.

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Purpose: We assessed the suitability of pooled electronic health record (EHR) data from clinical research networks (CRNs) of the patient-centered outcomes research network to conduct studies of the association between tumor necrosis factor inhibitors (TNFi) and infections.

Methods: EHR data from patients with one of seven autoimmune diseases were obtained from three CRNs and pooled. Person-level linkage of CRN data and Centers for Medicare and Medicaid Services (CMS) fee-for-service claims data was performed where possible.

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The critically endangered western gorillas () are divided into two subspecies: the western lowland () and the Cross River () gorilla. Given the difficulty in sampling wild great ape populations and the small estimated size of the Cross River gorilla population, only one whole genome of a Cross River gorilla has been sequenced to date, hindering the study of this subspecies at the population level. In this study, we expand the number of whole genomes available for wild western gorillas, generating 41 new genomes (25 belonging to Cross River gorillas) using single shed hairs collected from gorilla nests.

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