Publications by authors named "Oana-Veronica Frederiksen"
Background: Concussion leads to persistent post-concussion symptoms (PPCS) in up to one-third of those affected. While previous research has linked the initial trauma to elevated serum levels of neurofilament light chain (NFL), inflammatory markers, and neurotoxic metabolites within the kynurenine pathway, few studies have explored their relevance in PPCS. This study aims to investigate these biomarkers in PPCS patients, elucidating their relevance in the prolonged phase of concussion.
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- Young individuals with persistent post-traumatic headache (PTH) after mild traumatic brain injury (mTBI) often experience a combination of migraine-like and tension-type headaches, with migraine-like headaches also being prevalent.
- Many participants reported triggers such as stress, sleep disturbances, and bright lights, with over 80% noting that work-related activities worsened their headaches, while rest provided relief.
- Simple analgesics were the most commonly used treatment (88%), but prophylactic medications were rarely utilized (5%), and alternative strategies like bedrest and physiotherapy were also frequently employed.
Background: About 5-15 % of patients with concussion experience persistent post-concussion symptoms (PCS) longer than 3 months post-injury.
Objective: To explore the feasibility of a new intervention for young patients with persistent PCS and long-term changes after intervention.
Methods: Thirty-two consecutive patients (15-30 years) with persistent PCS 2-4 months post-injury were recruited from a cohort study or referred to a non-randomized feasibility study of an individually tailored, 8-week, multidisciplinary intervention.
Diffusion MRI findings in patients with extensive and minimal post-concussion symptoms after mTBI and healthy controls: a cross sectional study.
Brain Inj
July 2018
Primary Objectives: We hypothesized that the microstructure of the corpus callosum, thalamus and hippocampus, as measured with diffusion and Mean of the Kurtosis Tensor (MKT) MRI, differs between healthy subjects and patients with extensive and minimal post-concussion symptoms (PCS) and that MKT measures correlate with PCS severity and self-reported cognitive symptoms.
Research Design: A cross-sectional study comparing patients with extensive PCS and patients with minimal PCS 2-5 months after mild traumatic brain injury (mTBI) with each other and with an external healthy control group.
Methods And Procedures: Diffusion MRI was obtained in 25 patients with extensive PCS and in 25 patients with minimal PCS as measured by the Rivermead Post-concussion Symptoms Questionnaire.