Analyzing who is relevant to engage in environmental decision-making processes by interests, influence and impact: The 3i framework.

Outcomes in participatory environmental processes are strongly affected by choices about who is engaged. Inclusive engagement diversifies the range of interests and perspectives represented, including those from vulnerable and marginalized groups, ultimately contributing to more socially and environmentally sustainable and equitable outcomes. However, existing "stakeholder analysis" methods often bias participant identification away from disenfranchised groups with limited pre-existing interest or influence, instead favoring the most easily accessed and influential stakeholders.

NeuroSAFE PROOF: study protocol for a single-blinded, IDEAL stage 3, multi-centre, randomised controlled trial of NeuroSAFE robotic-assisted radical prostatectomy versus standard robotic-assisted radical prostatectomy in men with localized prostate cancer.

Background: Robotic radical prostatectomy (RARP) is a first-line curative treatment option for localized prostate cancer. Postoperative erectile dysfunction and urinary incontinence are common associated adverse side effects that can negatively impact patients' quality of life. Preserving the lateral neurovascular bundles (NS) during RARP improves functional outcomes.

Negative mpMRI Rules Out Extra-Prostatic Extension in Prostate Cancer before Robot-Assisted Radical Prostatectomy.

The accuracy of multi-parametric MRI (mpMRI) in the pre-operative staging of prostate cancer (PCa) remains controversial. The purpose of this study was to evaluate the ability of mpMRI to accurately predict PCa extra-prostatic extension (EPE) on a side-specific basis using a risk-stratified 5-point Likert scale. This study also aimed to assess the influence of mpMRI scan quality on diagnostic accuracy.

Type 1 diabetes mellitus and educational attainment in childhood: a systematic review.

Objectives: The primary objective of this systematic review was to evaluate available literature on whether type 1 diabetes mellitus (T1DM) has an impact on educational attainment in individuals undertaking high stakes standardised testing at the end of compulsory schooling.

Design: A systematic review was undertaken comparing educational attainment for individuals with and without T1DM who have undertaken high stakes testing at the end of compulsory schooling.

Data Sources: A comprehensive search of MEDLINE, MEDLINE (epub ahead of print, in-process and other non-indexed citations), EMBASE, Web of Science, British Education Index, Education Resources Information Center and Cumulative Index to Nursing and Allied Health Literature was undertaken on 15 January 2018 and updated on 17 January 2019.

Antibiotic exposure and the risk of colorectal adenoma and carcinoma: a systematic review and meta-analysis of observational studies.

Aim: The Incidence of colorectal cancer (CRC) is increasing, and evidence suggests that maladaptation of the bowel microbiome may be associated with colorectal carcinogenesis. Consumption of antibiotics may cause imbalance of the bowel microbiome but research assessing an association between antibiotic exposure and CRC is inconsistent. The aim of this systematic review and meta-analysis was to appraise and synthesize the available evidence.

Intraoperative Frozen Section for Margin Evaluation During Radical Prostatectomy: A Systematic Review.

Context: Surgical margin status and preservation of the neurovascular bundles (NVB) are important prognostic indicators for oncological and functional outcomes of patients undergoing radical prostatectomy (RP). Intraoperative frozen section (IFS) has been used to evaluate margin status during surgery with the intention of reducing positive surgical margins (PSMs) and guiding safe preservation of the NVBs during RP, but its value is controversial.

Objective: To evaluate current literature comparing outcomes of men undergoing RP with IFS versus RP without IFS.

NeuroSAFE robot-assisted laparoscopic prostatectomy versus standard robot-assisted laparoscopic prostatectomy for men with localised prostate cancer (NeuroSAFE PROOF): protocol for a randomised controlled feasibility study.

Introduction: Robot-assisted laparoscopic prostatectomy (RALP) offers potential cure for localised prostate cancer but is associated with considerable toxicity. Potency and urinary continence are improved when the neurovascular bundles (NVBs) are spared during a nerve spare (NS) RALP. There is reluctance, however, to perform NS RALP when there are concerns that the cancer extends beyond the capsule of the prostate into the NVB, as NS RALP in this instance increases the risk of a positive surgical margin (PSM).

Association between type 1 diabetes mellitus and educational attainment in childhood: a systematic review protocol.

Introduction: Type 1 diabetes has the potential to significantly impact children's educational attainment. With the increase in incidence, quantifying this effect would be useful to assess how much additional support should be focused on children with type 1 diabetes in school.

Methods And Analysis: We will conduct a systematic review of all observational studies and randomised controlled trials, including individuals both with and without a diagnosis of type 1 diabetes who have undertaken high stakes testing at the end of compulsory schooling when under 18 years of age.

Between-Session Reliability of Isometric Midthigh Pull Kinetics and Maximal Power Clean Performance in Male Youth Soccer Players.

Dos'Santos, T, Thomas, C, Comfort, P, McMahon, JJ, Jones, PA, Oakley, NP, and Young, AL. Between-session reliability of isometric midthigh pull kinetics and maximal power clean performance in male youth soccer players. J Strength Cond Res 32(12): 3373-3381, 2018-The aim of the study was to determine the between-session reliability of isometric midthigh pull (IMTP) kinetics and maximal weight lifted during the power clean (PC) in male youth soccer players, and to identify the smallest detectable differences between sessions.

Early surgical outcomes and oncological results of robot-assisted partial nephrectomy: a multicentre study.

Objective: To describe a multicentre experience of robot-assisted partial nephrectomy (RAPN) in northern England, with focus on early surgical outcomes and oncological results.

Patients And Methods: All consecutive patients undergoing RAPN at four tertiary referral centres in northern England in the period 2012-2015 were included for analysis. RAPN was performed via a transperitoneal approach using a standardized technique.

A case of laparoscopic ureteric reimplantation in a solitary urinary system.

Ureteric strictures can be caused by traumatic pelvic surgery, urolithiasis and instrumentation. There are various treatment options for ureteric stricture, including laparoscopic ureteric reimplantation. A 56-year-old female with a history of chronic left pelviureteric junction obstruction presented with urosepsis secondary to right-sided urolithiasis.

Diethylstilboestrol for the treatment of prostate cancer: past, present and future.

The aim of this review was to discuss the most recent data from current trials of diethylstilboestrol (DES) to identify its present role in advanced prostate cancer treatment as new hormonal therapies emerge. The most relevant clinical studies using DES in castration-refractory prostate cancer (CRPC) were identified from the literature. The safety, efficacy, outcomes and mechanisms of action are summarized.

Bladder neck sparing in radical prostatectomy.

The role of a bladder neck sparing (BNS) technique in radical prostatectomy (RP) remains controversial. The potential advantages of improved functional recovery must be weighed against oncological outcomes. We performed a literature review to evaluate the current knowledge regarding oncological and functional outcomes of BNS and bladder neck reconstruction (BNr) in RP.

A robust strategy for the preparation of libraries of metallopeptides. A new paradigm for the discovery of targeted molecular imaging and therapy agents.

A robust method for synthesizing structurally diverse metallopeptide libraries using a Re(i) complex of a non-natural amino acid was developed as a way to accelerate the discovery of novel molecular imaging probes.

Laparoscopic pyeloplasty: the retroperitoneal approach is suitable for establishing a de novo practice.

Background: Laparoscopic dismembered pyeloplasty has become the "gold-standard" procedure for pelviureteric junction (PUJ) obstruction but consists of a steep learning curve especially via the retroperitoneal route.

Aims: To examine the feasibility and safety of introducing this technique via the retroperitoneal approach to a laparoscopic naïve center.

Settings And Design: A retrospective data analysis of a single surgeon's (NEO) series from a large UK teaching hospital.

Use of optical dilating trocar for initial access during extraperitoneal laparoscopic radical prostatectomy.

Background And Purpose: For fully extraperitoneal laparoscopic radical prostatectomy, open port placement is standard. This takes quite some time, so with the availability of trocars that combine optical control and radial dilation, an easier and faster technique was tested.

Patients And Methods: In 70 consecutive cases, preperitoneal space creation was attempted with only a 1-cm skin incision, developing further access using an optical dilating trocar with a laparoscope.

Ureteric embolization: an alternative treatment strategy for urinary fistulae complicating advanced pelvic malignancy.

Objective: To report experience with a minimally invasive technique for palliation of urinary fistula/incontinence complicating advanced pelvic malignancy or its treatment.

Patients And Methods: We used ureteric embolization with permanent nephrostomy drainage in eight renal units in five patients for palliation of symptoms. All procedures were done under local anaesthesia as day-case procedures.

Clinical implications of prostate-specific antigen (PSA).

Prostate-specific antigen(PSA) is currently the tumour marker of choice for prostatic carcinoma. This article examines the current literature on the application of PSA for cancer detection (concentrating on values of PSA in the normal and 'grey' areas of 2.5-10 ng/ml), in staging of the disease and prediction of treatment response.

The laparoscopic nephrectomy learning curve: a single centre's development of a de novo practice.

Objective: There has been a dramatic increase in the interest and practice of laparoscopic urology, with nephrectomy having become the commonest laparoscopic urological procedure. Compared with open nephrectomy, it results in reduced morbidity and shorter convalescence times while maintaining oncological safety. However, while these results predominately stem from institutions with well developed laparoscopic programmes, little is known about the results in centres that have newly adopted this technique.