Structural characterisation of the complete cycle of sliding clamp loading in Escherichia coli.

Ring-shaped DNA sliding clamps are essential for DNA replication and genome maintenance. Clamps need to be opened and chaperoned onto DNA by clamp loader complexes (CLCs). Detailed understanding of the mechanisms by which CLCs open and place clamps around DNA remains incomplete.

Identifying images in the biology literature that are problematic for people with a color-vision deficiency.

To help maximize the impact of scientific journal articles, authors must ensure that article figures are accessible to people with color-vision deficiencies (CVDs), which affect up to 8% of males and 0.5% of females. We evaluated images published in biology- and medicine-oriented research articles between 2012 and 2022.

Pacific people living in New Zealand are most commonly referred with eczema to dermatologists.

Background: There is a lack of literature concerning dermatological conditions affecting patients of Pacific ethnicity.

Aim: To investigate dermatological conditions in patients of Pacific ethnicity referred to dermatology from 2016 to 2022.

Methods: Single-centre study of electronic referrals to dermatology from January 2016 to May 2022.

Vulval dermatoses: A review of referrals to dermatology.

We undertook a retrospective observational review of patients referred to a tertiary dermatology department with vulval complaints over 12 months. The most common provisional diagnoses made by the referrer and final dermatology diagnoses were lichen sclerosus (54% and 38%), dermatitis (12.7% and 16.

Assessing the Utility of Multimodal Large Language Models (GPT-4 Vision and Large Language and Vision Assistant) in Identifying Melanoma Across Different Skin Tones.

The large language models GPT-4 Vision and Large Language and Vision Assistant are capable of understanding and accurately differentiating between benign lesions and melanoma, indicating potential incorporation into dermatologic care, medical research, and education.

Using Artificial Intelligence as a Melanoma Screening Tool in Self-Referred Patients.

Introduction: Early detection of melanoma requires timely access to medical care. In this study, we examined the feasibility of using artificial intelligence (AI) to flag possible melanomas in self-referred patients concerned that a skin lesion might be cancerous.

Methods: Patients were recruited for the study through advertisements in 2 hospitals in Halifax, Nova Scotia, Canada.

Timeliness of diagnosis and treatment of cutaneous melanoma with dermatology, general practice, plastics surgery collaboration - are we meeting standards?

Introduction Melanoma is a serious type of skin cancer with a high burden in New Zealand. MelNet Quality Statements (2021) guide the timeliness of investigations and management for melanoma patients, who might experience long delays waiting for treatment. Aim To assess compliance of melanoma diagnosis and treatment timeliness with the MelNet Quality Statements at Waikato Hospital and in primary care for melanoma and melanoma in situ (MIS).

Store-and-Forward Teledermatology for Assessing Skin Cancer in 2023: Literature Review.

Background: The role of teledermatology for skin lesion assessment has been a recent development, particularly, since the COVID-19 pandemic has impacted the ability to assess patients in person. The growing number of studies relating to this area reflects the evolving interest.

Objective: This literature review aims to analyze the available research on store-and-forward teledermatology for skin lesion assessment.

Teledermatology for Enhancing Skin Cancer Diagnosis and Management: Retrospective Chart Review.

Background: Skin cancer rates are at all-time highs, but the shortage of dermatologists compels patients to seek medical advice from general practitioners. A new referral pathway called the Suspected Skin Cancer (SSC) service was established to provide general practitioners in Waikato, New Zealand, with rapid diagnosis and treatment advice for lesions suspicious for skin cancer.

Objective: The aim of this study was to assess the quantity, quality, and characteristics of referrals to the SSC teledermatology service during its first 6 months.

A 9-Year Teledermoscopy Service in New Zealand: Retrospective Service Review.

Background: A teledermoscopy service was established in January 2010 wherein patients attended nurse-led clinics for the imaging of lesions of concern and remote diagnosis by a dermatologist.

Objective: This study aims to review the number of visits, patient characteristics, the efficiency of the service, and the diagnoses made.

Methods: We evaluated the waiting times and diagnoses of skin lesions for all patient visits from January 1, 2010, to May 31, 2019.

Hidden Glutathione Transferases in the Human Genome.

With the development of accurate protein structure prediction algorithms, artificial intelligence (AI) has emerged as a powerful tool in the field of structural biology. AI-based algorithms have been used to analyze large amounts of protein sequence data including the human proteome, complementing experimental structure data found in resources such as the Protein Data Bank. The EBI AlphaFold Protein Structure Database (for example) contains over 230 million structures.

The importance of family support to engage and retain girls in male dominated action sports. A qualitative study of young people's perspectives.

Issue Addressed: Social support is positively correlated with physical activity (PA), especially amongst girls, but is underexplored in male-dominated action sports (e.g., mountain biking, skateboarding and surfing).

Benign Keratosis: A Useful Term?

Introduction: Seborrheic keratosis (SK), lichen planus-like keratosis (LPLK), and solar lentigo (SL) are common benign skin lesions. These lesions are frequently seen adjacent to each other or can arise from one another. They can sometimes be difficult to differentiate despite having distinct histopathological features.

Anticipation dialogs in Vermont's system of mental healthcare: Sustaining the growth of a dialogic practice culture.

Open dialog is both a therapeutic approach and a way of organizing the system of mental healthcare that has been evolving in Finland since the 1980s. In Vermont, over the last decade, there has been an organic statewide effort to begin to integrate dialogic principles into the public system of mental healthcare. Because of the organic nature of these initiatives, there have not been coordinated systemic changes to support dialogic practices.

Initiation of genomics-assisted breeding in Virginia-type peanuts through the generation of a reference genome and informative markers.

Introduction: Virginia-type peanut, , is the second largest market class of peanut cultivated in the United States. It is mainly used for large-seeded, in-shell products. Historically, Virginia-type peanut cultivars were developed through long-term recurrent phenotypic selection and wild species introgression projects.