Publications by authors named "Oaitse Motsamai"
Article Synopsis
- A 36-month isoniazid preventive therapy (36IPT) was found to be more effective than a shorter 6-month version (6IPT) in preventing tuberculosis (TB) in HIV-infected adults in Botswana, but the lasting benefits were evaluated post-trial.
- During the follow-up period, TB incidence rates were similar between both treatment groups, suggesting the effectiveness of 36IPT diminished over time.
- Antiretroviral therapy (ART) was linked to lower mortality rates but did not significantly reduce TB cases in the posttrial phase, indicating a need for additional strategies to prevent TB in HIV patients on long-term ART in high-risk areas.
Background: In accordance with WHO guidelines, people with HIV infection in Botswana receive daily isoniazid preventive therapy against tuberculosis without obtaining a tuberculin skin test, but duration of prophylaxis is restricted to 6 months. We aimed to assess effectiveness of extended isoniazid therapy.
Methods: In our randomised, double-blind, placebo-controlled trial we enrolled adults infected with HIV aged 18 years or older at government HIV-care clinics in Botswana.
Rationale: Isoniazid preventive therapy is effective in reducing the risk of tuberculosis (TB) in persons living with HIV (PLWH); however, screening must exclude TB disease before initiating therapy. Symptom screening alone may be insufficient to exclude TB disease in PLWH because some PLWH with TB disease have no symptoms. The addition of chest radiography (CXR) may improve disease detection.
View Article and Find Full Text PDFRationale: Little is known about the incidence of isoniazid-associated hepatitis in HIV-infected Africans who receive both isoniazid preventive therapy (IPT) and antiretroviral therapy (ART).
Objectives: To assess the rate of and risk factors for isoniazid (INH)-associated hepatitis in persons living with HIV (PLWH) during IPT.
Methods: PLWH recruited for a clinical trial received 6 months of open-label, daily, self-administered INH at public health clinics.
Objectives: To describe reasons for exclusion from isoniazid tuberculosis preventive therapy (IPT) and outcomes of persons living with HIV (PLWH) during 6 months of IPT.
Methods: In a clinical trial conducted in government clinics, first screening (screen 1) used National IPT Program guidelines and a second screening (screen 2) was trial specific. Adherence was defined as attending 6 monthly visits.