Changing contexts: A quasi-experiment examining adolescent delinquency and the transition to high school.

In a quasi-experiment, we examine whether changing schools during the transition from 8th to 9th grade influences adolescent delinquency, using a sample of more than 14,000 students in 26 public school districts (PROSPER study). The dataset follows students for eight waves from 6th through 12th grade and facilitates a unique, direct comparison of students who change schools with those who remain in the same school during this period. Results show that students who transition between schools report significantly less delinquency after the shift than those who do not, and that this difference persists through 10th grade.

Clinical Validation of Companion Diagnostics for the Selection of Patients with Non-Small Cell Lung Cancer Tumors Harboring Epidermal Growth Factor Receptor Exon 20 Insertion Mutations for Treatment with Amivantamab.

Amivantamab, an epidermal growth factor receptor (EGFR)-c-Met bispecific antibody, targets activating/resistance EGFR mutations and MET mutations/amplifications. In the ongoing CHRYSALIS study (ClinicalTrials.gov Identifier: NCT02609776), amivantamab demonstrated antitumor activity in patients with non-small cell lung cancer harboring EGFR exon 20 insertion mutations (ex20ins) that progressed on or after platinum-based chemotherapy, a population in which amivantamab use has been approved by the US Food and Drug Administration.

Similarity of friends versus nonfriends in adolescence: Developmental patterns and ecological influences.

This study examines developmental change across adolescence in the similarity of friends versus nonfriends. This differential in similarity is a key aspect of the organization of the peer context of development: The stronger the correlation between friends for an attribute, the more the attribute delineates clustering and divisions of friendships. We investigated change in the correlation between friends across 12 attributes covering demographics, orientations to key institutions (family, school, religion), and problem behavior, and we expected that the link between similarity and friendship would increase during adolescence for most attributes other than gender.

Why predict climate hazards if we need to understand impacts? Putting humans back into the drought equation.

Virtually all climate monitoring and forecasting efforts concentrate on hazards rather than on impacts, while the latter are a priority for planning emergency activities and for the evaluation of mitigation strategies. Effective disaster risk management strategies need to consider the prevailing "human terrain" to predict who is at risk and how communities will be affected. There has been little effort to align the spatiotemporal granularity of socioeconomic assessments with the granularity of weather or climate monitoring.

Peer Influence, Friend Selection, and Gender: How Network Processes Shape Adolescent Smoking, Drinking, And Delinquency.

We examine gender differences in the extent to which the social network processes of peer influence and friend selection explain why adolescents tend to exhibit similar risky behaviors as their friends for three problem behaviors (smoking, drinking, and delinquency). Using dynamic Stochastic Actor-Oriented Models (SAOMs), we analyze five waves of data on a large sample of 13,214 adolescents from 51 friendship networks. While both processes explain patterns of risky activities for girls and boys, the delinquent behavior of girls is more susceptible to influence and girls are especially likely to select friends who have similar smoking behaviors to their own.

Social Network Implications of Normative School Transitions in Non-Urban School Districts.

This article expands research on normative school transitions (NSTs) from elementary to middle school or middle to high school by examining the extent to which they disrupt structures of friendship networks. Social network analysis is used to quantify aspects of connectedness likely relevant to student experiences of social support. Data were drawn from 25 communities followed from sixth to ninth grades.

Promoting Afterschool Quality and Positive Youth Development: Cluster Randomized Trial of the Pax Good Behavior Game.

This randomized trial tested a strategy originally developed for school settings, the Pax Good Behavior Game (PAX GBG), in the new context of afterschool programs. We examined this approach in afterschool since 70% of all juvenile crime occurs between the hours of 3-6 pm, making afterschool an important setting for prevention and promotion. Dual-career and working families need monitoring and supervision for their children in quality settings that are safe and appropriately structured.

Aging alters mRNA expression of amyloid transporter genes at the blood-brain barrier.

Decreased clearance of potentially toxic metabolites, due to aging changes, likely plays a significant role in the accumulation of amyloid-beta (Aβ) peptides and other macromolecules in the brain of the elderly and in the patients with Alzheimer's disease (AD). Aging is the single most important risk factor for AD development. Aβ transport receptor proteins expressed at the blood-brain barrier are significantly altered with age: the efflux transporters lipoprotein receptor-related protein 1 and P-glycoprotein are reduced, whereas the influx transporter receptor for advanced glycation end products is increased.

Measuring afterschool program quality using setting-level observational approaches.

As the importance of afterschool hours for youth development is widely acknowledged, afterschool settings have recently received increasing attention as an important venue for youth interventions. A range of intervention programs have been in place, generally aiming at positive youth development through enhancing the quality of programs. A growing need has thus arisen for reliable and valid measures of afterschool quality.

Diffusion of Intervention Effects: The Impact of a Family-Based Substance Use Prevention Program on Friends of Participants.

Purpose: We tested whether effects of the Strengthening Families Program for Youth 10-14 (SFP10-14) diffused from intervention participants to their friends. We also tested which program effects on participants accounted for diffusion.

Methods: Data are from 5,449 students (51% female; mean initial age = 12.

P-glycoprotein expression and amyloid accumulation in human aging and Alzheimer's disease: preliminary observations.

P-glycoprotein (P-gp), part of the blood-brain barrier, limits drug access to the brain and is the target for therapies designed to improve drug penetration. P-gp also extrudes brain amyloid-beta (Aβ). Accumulation of Aβ is a hallmark of Alzheimer's disease (AD).

Social Networks and the Diffusion of Adolescent Problem Behavior: Reliable Estimates of Selection and Influence from Sixth Through Ninth Grades.

Seeking to reduce problematic peer influence is a prominent theme of programs to prevent adolescent problem behavior. To support the refinement of this aspect of prevention programming, we examined peer influence and selection processes for three problem behaviors (delinquency, alcohol use, and smoking). We assessed not only the overall strengths of these peer processes, but also their consistency versus variability across settings.

PARTNERSHIP TRANSITIONS AND ANTISOCIAL BEHAVIOR IN YOUNG ADULTHOOD: A WITHIN-PERSON, MULTI-COHORT ANALYSIS.

Objectives: This study examines the effects of young adult transitions into marriage and cohabitation on criminal offending and substance use, and whether those effects changed since the 1970s as marriage rates declined and cohabitation rates rose dramatically. It also examines whether any beneficial effects of cohabitation depend on marriage intentions.

Methods: Using multi-cohort national panel data from Monitoring the Future ( = 15,875), the authors estimated fixed effects models relating within-person changes in marriage and cohabitation to changes in criminal offending and substance use.

Delinquency and peer acceptance in adolescence: a within-person test of Moffitt's hypotheses.

We tested 2 hypotheses derived from Moffitt's (1993) taxonomic theory of antisocial behavior, both of which are central to her explanation for the rise in delinquency during adolescence. We tested whether persistently delinquent individuals become more accepted by their peers during adolescence and whether individuals who abstain from delinquent behavior become less accepted. Participants were 4,359 adolescents from 14 communities in the PROSPER study, which assessed friendship networks and delinquency from 6th (M = 11.

Emergence of mixed-sex friendship groups during adolescence: Developmental associations with substance use and delinquency.

Prospective longitudinal data from over 14,000 youth residing in 28 communities in the rural United States were analyzed to examine the emergence of mixed-sex friendship groups in early adolescence. Youth were surveyed on 5 occasions between fall of 6th grade and spring of 9th grade. At each assessment, youth reported the names of up to 7 same-grade friends and described patterns of alcohol use, cigarette use, and delinquency.

Amyloid-beta accumulation, neurogenesis, behavior, and the age of rats.

The goals of this research were to describe age-related changes in brain biochemistry and behavior, and the relationships between them. The chronological ages of greatest change are particularly important for targeting interventions. In this experiment, 36 Fischer 344/Brown-Norway rats (3, 12, 20, and 30 months old) were trained in lever boxes on temporal discrimination tasks.

Friends as a Bridge to Parental Influence: Implications for Adolescent Alcohol Use.

The current study investigates the possibility that friendship networks connect adolescents to influence from a broader group of adults beyond their own families. In doing so, we combine two rich traditions of research on adult influence on children and adolescents. Family research has suggested a number of ways in which effective parenting can reduce deviant behavior among adolescents.

Adolescent peer networks and the potential for the diffusion of intervention effects.

Many evaluation studies assess the direct effect of an intervention on individuals, but there is an increasing interest in clarifying how interventions can impact larger social settings. One process that can lead to these setting-level effects is diffusion, in which intervention effects spread from participants to non-participants. Diffusion may be particularly important when intervention participation rates are low, as they often are in universal family based prevention programs.

Friendship group position and substance use.

This paper examines how an adolescent's position relative to cohesive friendship groups in the school-wide social network is associated with alcohol, tobacco, and marijuana use. We extend prior research in this area by refining the categories of group positions, using more extensive friendship information, applying newer analytic methods to identify friendship groups, and making strategic use of control variables to clarify the meaning of differences among group positions. We report secondary analyses of 6th through 9th grade data from the PROSPER study, which include approximately 9500 adolescents each year from 27 school districts and 368 school grade cohort friendship networks.

Peers and the Emergence of Alcohol Use: Influence and Selection Processes in Adolescent Friendship Networks.

This study addresses not only influence and selection of friends as sources of similarity in alcohol use, but also peer processes leading drinkers to be chosen as friends more often than non-drinkers, which increases the number of adolescents subject to their influence. Analyses apply a stochastic actor-based model to friendship networks assessed five times from 6 through 9 grades for 50 grade cohort networks in Iowa and Pennsylvania, which include 13,214 individuals. Results show definite influence and selection for similarity in alcohol use, as well as reciprocal influences between drinking and frequently being chosen as a friend.

Apparent Motives for Aggression in the Social Context of the Bar.

Objective: Little systematic research has focused on motivations for aggression and most of the existing research is qualitative and atheoretical. This study increases existing knowledge by using the theory of coercive actions to quantify the apparent motives of individuals involved in barroom aggression. Objectives were to examine: gender differences in the use of compliance, grievance, social identity, and excitement motives; how motives change during an aggressive encounter; and the relationship of motives to aggression severity.

The utility of ionotropic glutamate receptor antagonists in the treatment of nociception induced by epidural glutamate infusion in rats.

Background: The authors have previously demonstrated that human herniated disc material contains high concentrations of free glutamate. In an experimental model, elevated epidural glutamate concentrations in the lumbar spine can cause a focal hyperesthetic state.

Methods: Rats underwent epidural glutamate infusion in the lumbar spine by a miniosmotic pump over a 72-hour period.

Effects of PROSPER on the influence potential of prosocial versus antisocial youth in adolescent friendship networks.

Objectives: We test the hypothesis that an evidence-based preventive intervention will change adolescent friendship networks to reduce the potential for peer influence toward antisocial behavior. Altering adolescents' friendship networks in this way is a promising avenue for achieving setting-level prevention benefits such as expanding the reach and durability of program effects.

Methods: Beginning in 2002, the Promoting School-University Partnerships to Enhance Resilience (PROSPER) randomized control trial assigned two entire sixth-grade cohorts of 14 rural and small town school districts in Iowa and Pennsylvania to receive the intervention and of 14 to control.

Measuring collective efficacy among children in community-based afterschool programs: exploring pathways toward prevention and positive youth development.

Collective efficacy refers to a perceived sense of connectedness and willingness to intervene among youth, and is a potential aspect of positive youth development (Larson in Am Psychol 55:170-183, 2000; Lerner et al. in Child Dev 71:11-20, 2000; Sampson et al. in Science 277:918-924, 1997).