Outcomes of Total Joint Arthroplasty in Patients Who Have Ehlers-Danlos Syndrome: A Systematic Review and Meta-Analysis.

Background: Patients who have Ehlers-Danlos Syndrome (EDS), a group of connective tissue disorders characterized by aberrant collagen synthesis and processing, have an increased likelihood of requiring a total joint arthroplasty (TJA), including total hip or knee arthroplasty (THA or TKA). This study aimed to synthesize outcomes following TJA in patients who have EDS.

Methods: This study was conducted using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.

Measurement Invariance on the Nine-Item Avoidant/Restrictive Food Intake Disorder Screen (NIAS) by Age and Reporter Status: Comparing ARFID Symptoms Among Self-Reporting Adults and Adolescents and Parent Reports of Children and Adolescents.

Objective: Self-report measures of ARFID symptoms (e.g., Nine-Item Avoidant/Restrictive Food Intake Disorder Screen [NIAS]) are used to assess symptom differences between groups.

Patient-reported outcome measures to assess mental and physical health status, functionality, and quality of life in patients with major depression or schizophrenia.

Background: Patient-reported outcomes measures (PROMs) are standardized self-administered tools that assess the patient's opinion on the level of health, quality of life, and disability among other aspects. The objective of this study was to gather information on physical and mental health in patients with major mental illness using PROMs.

Methods: This was an observational, naturalistic, prospective study carried out in adult stabilized outpatients attended at nine Adult Mental Health Centers in Barcelona, Spain.

Differential encoding of mammalian proprioception by voltage-gated sodium channels.

Animals requiring purposeful movement for survival are endowed with mechanoreceptors, called proprioceptors, that provide essential sensory feedback from muscles and joints to spinal cord circuits, which modulates motor output. Despite the essential nature of proprioceptive signaling in daily life, the mechanisms governing proprioceptor activity are poorly understood. Here, we identified nonredundant roles for two voltage-gated sodium channels (Nas), Na1.

Kinetic studies of bifurcating flavoproteins.

Since their original proposal in 2008, a number of broadly distributed flavoprotein systems catalyzing electron bifurcation have been identified that play key roles in the bioenergetics of anaerobic bacteria and archaea. While the overall thermodynamics of flavin-based electron bifurcation are now quite well-understood, the same cannot be said of their kinetic behavior. The present account represents a summary of results obtained with several electron-electron bifurcating systems, shamelessly focusing on work done in the authors' laboratory.

Data mining identifies meaningful severity specifiers for anorexia nervosa.

The fifth edition of defines anorexia nervosa (AN) severity based on body mass index (BMI). However, BMI categories do not reliably differentiate the intensity of AN and comorbid symptoms. Shape/weight overvaluation has been proposed as an alternative severity specifier.

Spatiotemporal modeling quantifies cellular contributions to uptake of Aspergillus fumigatus in the human lung.

The human lung is confronted daily with thousands of microbial invaders reaching the lower respiratory tract. An efficient response by the resident type 1 and type 2 alveolar epithelial cells (AECs) and alveolar macrophages (AMs) cells during the early hours of innate immunity is a prerequisite to maintain a non-inflammatory state, but foremost to rapidly remove harmful substances. One such human-pathogenic invader is the opportunistic fungus Aspergillus fumigatus.

The Dangers of Social Media as an Information Source: A Case Report of a Burn After Attempted Breast Tightening Using a PlasmaPen.

Cosmetic procedures are a trending topic on social networks. Many users share their experiences and knowledge but also promote procedures whose effectiveness and validity have not been proven, making them seem effective in the collective imagination through the viral effect they generate. Here, we describe a second-surface-degree burn all over the breast print caused by a non-standard aesthetic procedure popularized on social networks: the PlasmaPen Fibroblast (Sefton, United Kingdom).

A microscopy-based image analysis pipeline for the quantification of germination of filamentous fungi.

Germination is the fundamental process whereby fungi transition from the dormant and stress resistant spores into actively replicating cells such as hyphae. Germination is essential for fungal colonization of new environments and pathogenesis, yet this differentiation process remains relatively poorly understood. For filamentous fungi, the study of germination has been limited by the lack of high-throughput, temporal, low cost, and easy-to-use methods of quantifying germination.

Elevating the Field of Eating Disorders Through Scholarship and Thoughtfulness: Honoring the Legacy of Dr. Michael Strober.

This Virtual Issue of the International Journal of Eating Disorders honors the legacy of the late Dr. Michael Strober in the eating disorders and child psychiatry fields. Having served as Editor-in-Chief of the International Journal of Eating Disorders from 1983 to 2012, Dr.

An Opportunity for Developing Cancer Prevention Leadership in Mexico.

Cancer in Mexico is a major public burden for which rates are expected to increase over time. In settings like Mexico, much potential for reduction through cancer prevention efforts remains unrealized, due in part, to a lack of formal cancer prevention and control training and career opportunities. We trained a cadre of instructors to deliver a pilot cancer prevention education program for oncology professionals and leaders.

Early vs late ICU admission in patients with COVID-19 pneumonia.

Introduction: The type of admission to the Intensive Care Unit (ICU) influences the prognosis of patients with severe pneumonia and, in the case of patients with COVID-19 pneumonia, this is still unexplored. The objective of this study was to determine the differences between early and late ICU admission.

Methodology: A retrospective cohort study of patients with COVID-19 pneumonia at two high-complexity hospitals in Colombia.

Meta-analysis of 65 Adamantinoma case reports: Unveiling symptomatology, demographics, and treatment outcomes in contrast to prior understandings.

Adamantinomas are rare, malignant bone tumors predominantly affecting the tibia. This study compares demographics, clinical presentations, radiographic findings, metastasis rates, and treatment outcomes of adamantinoma cases from a contemporary review of 65 cases with a historical review by Keeney et al. (1989).

Differential encoding of mammalian proprioception by voltage-gated sodium channels.

Animals that require purposeful movement for survival are endowed with mechanosensory neurons called proprioceptors that provide essential sensory feedback from muscles and joints to spinal cord circuits, which modulates motor output. Despite the essential nature of proprioceptive signaling in daily life, the mechanisms governing proprioceptor activity are poorly understood. Here, we have identified distinct and nonredundant roles for two voltage-gated sodium channels (Nas), Na1.

A Serous Cystic Tumor and a Pancreatic Neuroendocrine Tumor in the Same Patient: A Case Report and Literature Review.

A serous cystic tumor is a rare entity that has a benign course. Its imaging characteristics, such as the presence of multiple cysts with or without nodular enhancement, can simulate other cystic or solid lesions of the pancreas. Identification of the enhancing scar with punctate calcifications on computed tomography (CT) or magnetic resonance imaging (MRI) may be a distinctive finding suggesting this diagnosis.

Communication Policy to Reduce Health Disparities: A Cross-Language Content Analysis of YouTube Television Advertising.

Introduction: This study aimed to identify disparate health-related marketing across English- and Spanish-language television networks in New York City, ultimately to inform policy that can counteract disproportionate health-related marketing that provides harmful content to and withholds beneficial information from Latinx populations.

Methods: A 2-week composite sample of primetime English-language (National Broadcasting Company and Columbia Broadcasting System) and Spanish-language (Telemundo and Univision) television networks from YouTube television was randomly drawn from September 7, 2022 to September 27, 2022 in New York City. A total of 9,314 health-related television advertisements were identified for systematic media content analysis and coded into categories: alcohol, core or noncore foods/beverages, mental health/tobacco prevention, health insurance, medical centers, and pharmaceuticals.

Evaluating the Distribution, Quality, and Educational Value of Videos Related to Knee Instability Exercises on the Social Media Platform TikTok.

Introduction TikTok, a globally popular short-form video platform, offers a unique space for healthcare professionals to share advice, particularly under common conditions such as knee pain or instability. Despite its popularity, doubts persist regarding the reliability of medical information disseminated on TikTok. This study aimed to evaluate the quality of TikTok videos as a source of patient information on knee instability, recognizing the need for a comprehensive assessment of potential misinformation on this influential social media platform.

Nickel(II)-Catalyzed Formal [3+2] Cycloadditions between Indoles and Donor-Acceptor Cyclopropanes.

This article describes the development of a nickel-catalyzed regio- and diastereoselective formal [3+2] cycloaddition between -substituted indoles and donor-acceptor cyclopropanes to synthesize cyclopenta[]indoles. Optimized reaction conditions provide the desired nitrogen-containing cycloadducts in up to 93% yield and 8.6:1 with complete regioselectivity.

,,-Di-chlorido-bis-(,-di-methyl-pyridin-4-amine-κ)bis-(dimethyl sulfoxide-κ)ruthenium(II).

The structure of the title compound, [RuCl(CHN)(CHOS)], has monoclinic (2/) symmetry. The Ru-N distances of the coordination compound are influenced by the chloride or di-methyl-sulfoxide-κ ligands. The mol-ecular structure exhibits disorder for two of the terminal methyl groups of a dimethyl sulfoxide ligand.

PyF2F: a robust and simplified fluorophore-to-fluorophore distance measurement tool for Protein interactions from Imaging Complexes after Translocation experiments.

Structural knowledge of protein assemblies in their physiological environment is paramount to understand cellular functions at the molecular level. Protein interactions from Imaging Complexes after Translocation (PICT) is a live-cell imaging technique for the structural characterization of macromolecular assemblies in living cells. PICT relies on the measurement of the separation between labelled molecules using fluorescence microscopy and cell engineering.

Biogenesis, germination, and pathogenesis of spores.

SUMMARYSpores are primary infectious propagules for the majority of human fungal pathogens; however, relatively little is known about their fundamental biology. One strategy to address this deficiency has been to develop the basidiospores of into a model for pathogenic spore biology. Here, we provide an update on the state of the field with a comprehensive review of the data generated from the study of basidiospores from their formation (sporulation) and differentiation (germination) to their roles in pathogenesis.