Mechanical and biological evaluations of novel electrospun PLLA composite scaffolds doped with oxide ceramics.

The objective of this study is to evaluate the in vitro performance of the novel electrospun composite scaffolds that are made of 10% PLLA in binary solvents (75 vol% dichloromethane: 25 vol% acetone) doped with 0.1 wt% of oxide ceramic powders (Hafnium dioxide (HfO), titanium dioxide (TiO), zirconium dioxide (ZrO) and silicon dioxide (SiO)). These composite scaffolds were characterized microscopically (SEM, TEM and EDX), mechanically (Vickers hardness and tensile strength) and in in vitro cell studies (biomineralization, protein absorption, and cytocompatibility) with MC3T3 pre-osteoblasts.